Bisacodyl drop pill and preparing method thereof

A technology of sacodyl dripping pills and bisacodyl, which is applied in the direction of pill delivery, digestive system, and drug combination, and can solve the problems of affecting the therapeutic effect of bisacodyl, large proportion of excipients, and long tablet disintegration time. It achieves the effect of convenient carrying and taking, reduced dosage of excipients, and small pill size

Inactive Publication Date: 2004-09-15
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Bisacodyl is odorless, tasteless, and almost insoluble in water. Its tablet disintegrates for a long time, has poor absorption, low bioavailability, and a large proportion of excipients. It is inconvenient for children, the elderly, bedridden patients, and patients with dysphagia to take it. Poor resistance, which affects the therapeutic effect of bisacodyl

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] prescription:

[0023] Bisacodyl 5g

[0024] Macrogol 6000 15g

[0025] Makes 1000 capsules

[0026] Preparation method: Take the bisacodyl fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone oil as a coolant, make pellets by drop method, and dry to obtain .

example 2

[0028] prescription:

[0029] Bisacodyl 5g

[0030] Macrogol 4000 15g

[0031] Makes 1000 capsules

[0032] Preparation method: Take bisacodyl fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone oil as a coolant, make pellets by drop method, and dry to obtain .

example 3

[0034] prescription:

[0035] Bisacodyl 5g

[0036] Macrogol 6000 5g

[0037] Macrogol 4000 10g

[0038] Makes 1000 capsules

[0039] Preparation method: Take the bisacodyl fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone oil as a coolant, and drip The legal pills are dried and obtained immediately.

[0040] 4. Example 4

[0041] prescription:

[0042] Bisacodyl 5g

[0043] Glyceryl monostearate 15g

[0044] Makes 1000 capsules

[0045] Preparation method: Take the bisacodyl fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate base, mix well, use ice water as a coolant, make pellets by drop method, and dry to obtain.

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PUM

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Abstract

The present invention utilizes ultramicropulverization and dripping pill preparation production process to make bisacodyl dripping pills, and can attain the goal of raising disintegration and dissolution speed, quickly obtaining therapeutic effect, raising stability of medicine, reducing dose of auxiliary material, reducing production cost and convenient administration. Said pill not only can be sucked, but also can be swallowed, and its compliance property is good.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to bisacodyl dripping pills and a preparation method thereof. Background technique [0002] Bisacodyl is a contact laxative, through direct contact with the intestinal mucosa, it stimulates its sensory nerve endings, causing increased intestinal reflex peristalsis and resulting in defecation. [0003] Bisacodyl works within 10 to 12 hours after oral administration, and is mainly excreted in feces. Only a small amount is absorbed after oral administration, and is excreted in urine in the form of glucuronide. It is clinically used for the treatment of constipation, and can also be used for cleaning the intestinal tract before abdominal X-ray examination or endoscopy, and for cleaning the intestinal tract before and after surgery. [0004] Bisacodyl is odorless, tasteless, and almost insoluble in water. Its tablet disintegrates for a long time, has poor ...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K9/20A61K31/438A61P1/10
Inventor钱进许军彭红李平朱丹刘孝乐
OwnerHONGYI SCI & TECH CO LTD NANCHANG