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Basic fibroblast growth factor recombining capsule and its prepn process

A fibroblast and growth factor technology, applied in the field of recombinant human basic fibroblast growth factor capsule and its preparation, can solve problems such as inability to completely cure ulcer disease, inability to effectively prevent recurrence, etc. The effect of less adverse reactions and high quality of healing

Inactive Publication Date: 2004-11-24
ZHUHAI ESSEX BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Drugs currently used to treat peptic ulcers mainly include gastric acid neutralizers, H 2 Receptor blockers, proton pump inhibitors, anti-Helicobacter pylori drugs, etc., but none of the existing drugs can completely cure ulcer disease, and cannot effectively prevent recurrence after drug withdrawal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0033] The invention is illustrated with the following examples:

[0034] 1. Prescription of rh-bFGF freeze-dried powder:

[0035] rh-bFGF stock solution 200mg

[0036] 20% Human Albumin 20g

[0037] Mannitol 20g

[0038] Distilled water (add to) 200g

[0039] Freeze-dried powder weighs about: 25g

[0040] 2. Capsule prescription

[0041] rh-bFGF freeze-dried powder 10g

[0042]Mannitol 160g

[0043] Total production: 1000 capsules

[0044] Dissolve rh-bFGF, human serum albumin and mannitol in distilled water according to the freeze-dried powder prescription, filter through a 0.22 μm microporous membrane, pack in freeze-dried trays, and freeze-dry at -50°C to 40°C for 24-24°C. 72 hours.

[0045] Pass the obtained freeze-dried powder through a 100-mesh sieve, and take a sample to measure the specific activity of rh-bFGF. Calculate the weight of the required diluent mannitol according to the specific activity unit of rh-bFGF in the lyophilized powder.

[0046] Dry man...

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Abstract

The recombinant human basic fibroblast growth factor capsule includes recombinant human basic fibroblast growth factor freeze dried powder 0.1-100 wt% and medicinal stuffing material 0-99.9 wt%. The preparation process includes dissolving mannitol, human blood albumin and recombinant human basic fibroblast growth factor in distilled water, abacterial filtering, freeze drying to obtain powder, sieving, mixing with stoved and sieved mannitol in certain ratio and capsulizing. The capsule is used in treating gastric ulcer in one completely new path different from traditional gastric ulcer treating medicines.

Description

technical field [0001] The invention relates to a recombinant human basic fibroblast growth factor capsule and a preparation method thereof, in particular to a recombinant human basic fibroblast growth factor capsule suitable for treating peptic ulcer disease and a preparation method thereof. Background technique [0002] Peptic ulcer disease (Peptic Ulcer, PU) is a common and frequently-occurring disease that has a great impact on human health and social progress. During the period, the patient has symptoms such as periodic epigastric pain, acid regurgitation, and belching, and is prone to recurrent episodes with a chronic course. Pathologically, peptic ulcer disease is characterized by ulceration of the gastric or duodenal mucosa. [0003] It is generally believed that gastric acid, pepsin erosion and Helicobacter pylori (HP) infection are the direct causes of peptic ulcer. Excessive secretion of gastric acid and pepsin, or some drugs, drinking, bile reflux and other fac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61K38/38A61P1/04
Inventor 陈咏郑赞顺朱爱堂方海洲姜若峰陈雪平兰暄
Owner ZHUHAI ESSEX BIO PHARMA
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