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Thyrotropic hormone diagnosis reagent paper and use thereof

A technology of thyrotropin and test strips, which is applied in the direction of biological testing, material inspection products, etc., can solve the problems of long operation time, radioactive isotopes, and short shelf life of reagents, and achieve rapid determination, stable reagents, and a wide range of applications Effect

Inactive Publication Date: 2005-01-19
黄勤 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing TSH assay methods also have some shortcomings, such as short shelf life of reagents, and some methods contain radioactive isotopes, etc.
In particular, the operation takes a long time, requires a relatively concentrated sample volume, and the measurement takes several hours to more than ten hours. It is not suitable for emergency testing and single-part determination, nor is it suitable for screening work.

Method used

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  • Thyrotropic hormone diagnosis reagent paper and use thereof
  • Thyrotropic hormone diagnosis reagent paper and use thereof
  • Thyrotropic hormone diagnosis reagent paper and use thereof

Examples

Experimental program
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Embodiment Construction

[0017] Below in conjunction with specific embodiment, further set forth the present invention:

[0018] For the regional composition of the TSH diagnostic test strip of the present invention see figure 1 , A and B are the upper and lower ends of the test strip, respectively, which are adhered to water-absorbing materials; D is pasted with immunogold complex dry slices, which contain specific anti-TSHβ antibodies; T and C are the reaction areas on the nitrocellulose membrane strip , T is the test area, coated with specific anti-TSHβ antibody, and C1 and C2 are quality control areas, coated with anti-TSHβ antibody.

[0019] The present invention adopts gold immune double-antibody sandwich technology (two anti-TSHβ specific antibodies are U.S. Santa Cruz Biotechnology.Inc products, working concentration is about 0.398 μ g / cm ), with nitrocellulose membrane (Sandeliss.Ldt product) as The carrier, using the capillary action of the microporous membrane, the liquid slowly seeps from...

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Abstract

This invention discloses an indicator paper for thyrotropin diagnosis, which comprises one testing area, one normal high limit control area, one normal low limit control area and a gold immune complex dry area. This invention also discloses the application of the indicator paper for thyrotropin diagnosis. It is a regular testing method to judge hypothalamus- hypophysis-thyroid axis function. This invention can be also used in the following fields: screening primary thyroid dysfunction such as hypothyroidism and hyperthyroidism; thyroid hormone substitution and abatement therapeutic efficacy detecting; hyperthyroidism and hypothyroidism patient diagnosis; thyroid function monitoring of iodine-assisting crowd and thyroid dysfunction of non-thyroid continuous monitoring.

Description

technical field [0001] The invention relates to a thyroid-stimulating hormone detection product, and more particularly, the invention relates to a thyroid-stimulating hormone diagnostic test strip. Background technique [0002] The thyroid gland is the largest endocrine gland in the human body. Its main function is to synthesize and release thyroid hormones (thyroxine (T4) and triiodothyronine (T3)), which affect the functions of various organs and systems throughout the body. Thyroid and tissue lesions can cause hyperthyroidism, hypothyroidism, thyroid tumors (benign and malignant), iodine deficiency disorders and other thyroid diseases. [0003] Both hypothyroidism and hyperthyroidism are relatively common endocrine diseases, and their prevalence rates have been increasing in recent years. In the late 1990s, a cluster sampling survey in two counties in the urban area and the suburbs of Beijing found that the prevalence of hypothyroidism, including subclinical hypothyroidi...

Claims

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Application Information

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IPC IPC(8): G01N33/53G01N33/78
Inventor 黄勤步世忠郭志勇闵红波
Owner 黄勤
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