179 results about "Thyroid function" patented technology

An alkylated hydroxyaromatic compound is disclosed which is prepared by reacting at least one hydroxyaromatic compound with at least one branched olefinic propylene oligomer having from about 20 to about 80 carbon atoms in the presence of an acid catalyst, wherein the at least one branched olefinic propylene oligomer is substantially free of any vinylidene content. The alkylated hydroxyaromatic compound has been determined to be substantially free of endocrine disruptive chemicals when the effects were quantified on pubertal development and thyroid function in the intact juvenile female rat.

The present invention relates to the use of a growth hormone (GH) secretagogue, such as a ghrelin-like compound, for the preparation of a medicament for the prophylaxis or treatment of ghrelin deficiency, and/or undesirable symptoms associated therewith, in an individual at risk of acquiring partial or complete ghrelin deficiency resulting from a medical treatment and/or from a pathological condition. The present invention also relates to use of a secretagogue compound for the preparation of a medicament for the prophylaxis or treatment of one or more of: loss of fat mass, loss of lean body mass, weight loss, cachexia, loss of appetite, immunological dysfunction, malnutrition, disrupted sleep pattern, sleepiness, reduction in intestinal absorption and/or intestinal mobility problems in an individual suffering from, or at risk of suffering from, ghrelin deficiency. Furthermore, the present invention relates to the use of a secretagogue, such as a ghrelin-like compound, for the production of a medicament for preventing weight increase in an individual either: a) being converted from a hyperthyroidic state to euthyroid state, or b) in remission from being converted from a hyperthyroidic state to euthyroid state.

The invention belongs to the technical field of immunodiagnosis, and discloses a thyroxine (T4) enzymatic chemiluminescence quantitative determination kit. The kit disclosed by the invention consists of a T4 standard product, an antibody pre-coated reaction plate, a horseradish peroxidase marker, diluent, cleaning mixture, and chemiluminescence substrate liquid. The kit disclosed by the invention has the advantages of quickness, handiness, sensitiveness, cheapness and high repeatability, and is an important index for diagnosis and therapeutic evaluation of hyperthyroidism and hypothyroidism. The invention has high clinic use value. The invention also provides a method to prepare the kit.

Embodiments of the invention generally relate to methods for improving thyroid function in healthy human beings.

Chinese traditional medicine for treating exophthalmic goiter in combination with diarrhea, wherein the recipe includes root of herbaceous peony 10g, nutgrass flatsedge rhizome 10g, white atractylodes rhizome 12g, coptis root 6g, root of pilose asiabell 15g, poria cocos wolf 10g, dried orange peel 6g, white hyacinth bean 10g, amomum fruit 3g, licorice root 6g, plantain seeds 20g, kudzuvine root 10g, banksia rose 10g, crude malt 15g, baked malt 15g, prunella spike 10g, thunberg fritillary bulb 15g, baikal skullcap root 8g, gentian root 12g, pericarpium trichosanthis 20g, grassleaved sweetflag rhizome 8g, schisandra fruit 10g, aspongopus 6g, spikenard 8g, magnolia bark 12g, tuber fleeceflower stem 9g and euphoria longan steud 15g. The Chinese medicament has simplified recipe, easy preparing process and low price.

The invention discloses a detection probe for DUOX2 gene mutation and a detection method thereof, particularly relates to a method for detecting DUOX2 gene mutation related to a congenital hypothyroidism (CH) pathogenic gene, and belongs to the technical field of molecular biology. A PCR primer sequence of a DUOX2 gene for detecting the CH is a nucleotide sequence as shown in SEQ ID No.1-SEQ ID No.18 in the sequence table. The detection probe has the advantages that the DUOX2 gene causing the CH is detected by utilizing new generation sequencing, and 24 new mutation sites which are not yet reported home or abroad are discovered. The detection probe applied to clinical gene mutation detection is beneficial to etiological analysis and diagnosis of CH, further recognition of mutation spectrum of the CH gene and further research on pathogenesis of CH.

The invention discloses a chemiluminescence quantitative detection kit for free triiodothyronine. The kit comprises a free triiodothyronine detection reaction plate, an enzyme conjugate, a luminescent substrate, a calibrator, a quality control material and washing concentrate, wherein the reaction plate is coated with a free triiodothyronine antibody. The kit can specifically and quantitatively detect the content of the free triiodothyronine in patient serum, and is used for the auxiliary diagnosis of thyroid dysfunction diseases. Compared with the conventional enzyme linked immunosorbent assay (ELISA) technology, the chemiluminescence immunoassay keeps high specificity of the ELISA technology, stability and reliability of a detection result, and convenience of operation, and can improve detection sensitivity simultaneously.

The invention relates to compositions for preventing chronic renal failure (CRF) in felines with hyperthyroidism wherein the compositions comprise (1) from about 28 to about 35% protein, the protein comprising at least about 75% vegetable protein, and (2) from about 0.1 to less than about 1 mg/kg iodine and/or from about 0.1 to about 1 mg/kg selenium. The invention also relates to compositions for treating CRF in hyperthyroid felines wherein the compositions comprise (1) from about 28 to about 35% protein, the protein comprising at least about 75% vegetable protein, and (2) from about 0.1 to less than about 0.3 mg/kg iodine and/or from about 0.1 to about 1 mg/kg selenium. The invention further relates to methods for preparing and using such compositions, articles of manufacture comprising such compositions, and means for communicating information about such compositions, methods, and articles of manufacture.

This invention discloses an indicator paper for thyrotropin diagnosis, which comprises one testing area, one normal high limit control area, one normal low limit control area and a gold immune complex dry area. This invention also discloses the application of the indicator paper for thyrotropin diagnosis. It is a regular testing method to judge hypothalamus- hypophysis-thyroid axis function. This invention can be also used in the following fields: screening primary thyroid dysfunction such as hypothyroidism and hyperthyroidism; thyroid hormone substitution and abatement therapeutic efficacy detecting; hyperthyroidism and hypothyroidism patient diagnosis; thyroid function monitoring of iodine-assisting crowd and thyroid dysfunction of non-thyroid continuous monitoring.

The invention provides a device for monitoring the thyroid function. The device comprises a heartbeat monitoring unit, wherein the heartbeat monitoring unit is used for monitoring heartbeat times and heartbeat wave data of a user; a transmission unit, wherein the transmission shaft is used for transmitting the detected heartbeat times and the heartbeat wave data of a user; a processing unit, wherein the processing unit is used for analyzing the heartbeat times and the heartbeat wave data and determining the result to determine the thyroid function based on the analyzed result; a feedback unit, wherein the feedback unit is used for sending suggestions to the user according to the analyzed result of the processing unit. The device for monitoring the thyroid function has the advantages of low expenses, no pain for the user and being suitable for long term monitoring of the thyroid function. The invention further provides a method for monitoring the thyroid function.

The present invention relates to a pharmaceutical composition for preventing or treating thyroid diseases and a food composition for improving thyroid function, comprising an extract from Lonicera caerulea L. car. Edulis fruits as an active ingredient.

The composition of the present invention may be useful for preventing or treating thyroid diseases such as hypothyroidism, hyperthyroidism, thyroid nodule, or thyroditis, and improving thyroid function. Since the extract from Lonicera caerulea L. car. Edulis fruits, which is an active ingredient of the present invention, is derived from natural products, there is no concern for side effects such as toxicity compared to synthetic medicine.

Provided are methods for the detection and diagnosis of Hypothyroidism. The methods are based on the discovery that altered levels of selected analytes in sample fluid, typically blood samples, of patients are supportive of a diagnosis of Hypothyroidism. At least twenty-four new biomarkers for hypothyroidism are thus disclosed (singly or in any combination), Thyroid Stimulating Hormone, Interleukin-12p40, Tumor Necrosis Factor Alpha, Tissue Factor, Interleukin-15, Insulin, Immunoglobulin E, Growth Stimulating Hormone, Calcitonin, Prostate-Specific Antigen, Interleukin-4, Granulocyte Macrophage Colony Stimulating Factor, Matrix Metalloproteinase 9, Lymphotactin, Fatty Acid Binding Protein, Alpha Fetoprotein, Alpha-2 Macroglobulin, Serum Glutamic Oxaloacetic Transaminase, Matrix Metalloproteinase 3, Cancer Antigen 125, Mumps Antibody, Double Stranded DNA Antibody, Proliferating Cell Nuclear Antigen Antibody, Smith Antibody, or Herpes Simplex Virus 1 Glycoprotein D Antibody. Altogether the concentrations of one or more of these analytes, as well as Thyroid Stimulating Hormone, or any combination thereof, provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering from Hypothyroidism. Kits containing reagents to assist in the analysis of fluid samples are also described.

The invention discloses a method for processing an instant sargassum fusiforme (pickle) product by using fresh sargassum fusiforme as well as selection of major raw materials. The preparation process comprises the following steps of: selecting a fresh sargassum fusiforme raw material, cleaning, blanching, cooling, salting, draining, selecting (removing impurities), cutting, desalting and arsenic removal, coarse filtration, dehydrating, finely selecting, preparing, packaging, sterilizing, cooling and packaging; and the following raw materials are selected: preserving and cold-storing salted vegetable, edible oil, gourmet powder, I+G, common salt, white sugar, sesame oil, soy sauce, pepper essence, garlic essence, hot pepper essence, etc. The product disclosed by the invention is abundant in nutrition, quite excellent in mouthfeel, clean and sanitary, free from seaweed fishy smell, ready-to-eat after opening the bag, and convenient to eat. The product, as long as being eaten for a long period, has functions of regulating a thyroid function, resisting coagulation, resisting creotoxin poisoning and tumor, reducing blood pressure, lowering blood lipid and reducing blood sugar.

The invention discloses a traditional Chinese medicine composite for treating thyroid associated ophthalmopathy and a preparation method of the traditional Chinese medicine composite. The traditional Chinese medicine composite is prepared from the following traditional Chinese medicines in parts by weight: 30-60 parts of radix curcumae, 30-60 parts of root of common peony, 30-80 parts of salviae miltiorrhizae, 60-120 parts of semen coicis, 20-60 parts of thunberg fritillary bulb, 10-30 parts of stiff silkworm and 30-80 parts of semen litchi. The invention designs a multi-time extraction technical route by taking water as a solvent. The traditional Chinese medicine composite disclosed by the invention can effectively lower the exophthalmos degree of the disease eye of the thyroid associated ophthalmopathy, and the total effective rate is 86.9%; the total effective rate of the main eye symptom and the sign integral curative effect of the disease eye of the thyroid associated ophthalmopathy is 91.8%; the total effective rate of the Chinese medicine syndrome integral curative effect of the thyroid associated ophthalmopathy patient is 90.3%; the lesion activity grade of the disease eyeof the thyroid associated ophthalmopathy can be effectively improved; and the thyroid function of the patient can be improved. The traditional Chinese medicine composite has high safety. The invention also discloses a preparation method for the traditional Chinese medicine composite granule.

The invention belongs to the field of technologic processing and application of aquatic product fermentation products, and concretely relates to a preparation method of an aquatic product-derived GABA with a hypothyroidism resisting effect. The method comprises the following steps: grinding a raw material to form a homogenate, adding water, adding glucose and monosodium glutamate to obtain a monosodium glutamate-containing culture solution; inoculating microbes into the culture solution, and carrying out fermentation culturing at 35-40DEG C for 2-14d to obtain a GABA-rich fermentation solution; removing thalli from the GABA-rich fermentation solution, decoloring, allowing the obtained solution to go through cationic resin, and collecting a GABA-rich eluate through a collector; and carrying out reduced pressure concentration on the eluate, and carrying out ethanol drying crystallization to obtain separated and purified GABA. The separated and purified GABA is processed to prepare an aqueous solution, and the aqueous solution is used to feed hypothyroidism model mice, and detection of thyroid function related various indexes is carried out to determine the hypothyroidism resisting effect of the GABA. The hypothyroidism resisting GABA has the characteristics of substantial curative effect, safety, convenience and no toxic side effects.

This invention relates to a method for treating or preventing hyperthyroidism secondary to chronic kidney disease by administering a sufficient amount of an active vitamin D analog utilizing a variety of effective treatment protocols.

The invention belongs to the technical field of traditional Chinese medicines and relates to a traditional Chinese medicinal composition for treating hyperthyroidism by employing the traditional Chinese medicines as raw materials. The traditional Chinese medicinal composition is prepared from the following crude medicines by weight: 5-20g of fructus gardeniae praeparatus, 3-15g of pangolin, 5-20g of a turtle shell, 10-30g of codonopsis pilosula, 8-30g of roasted rhizoma atractylodis macrocephalae, 10-30g of dried radix rehmanniae, 10-40g of astragalus membranaceus, 5-30g of angelica sinensis, 5-20g of radix bupleuri, 5-20g of rhizoma cyperi, 5-20g of radix curcumae, 5-20g of fritillary bulb, 10-30g of selfheal, 5-20g of rhizoma sparganii, 5-20g of curcuma zedoary, 3-15g of felwort, 5-25g of raspberries, 10-40g of semen plantaginis, 15-40g of spina date seeds, 5-40g of parched white peony roots, 5-25g of rhizoma atractylodis, 3-15g of honey-fried liquorice, 5-40g of coix seeds, 5-25g of glossy privet fruits and 3-20g of cortex albiziae. The traditional Chinese medicinal composition is capable of effectively treating thyroid gland dysfunction caused by autoimmune thyroiditis and treating both symptoms and root causes, is significant in curative effect, has a pure traditional Chinese medicine formula, and is free of a side effect, safe and reliable.

The invention discloses dog food and a preparation method thereof. The dog food comprises the following raw materials of wheat, black sesame seed powder, lotus root starch, mussel, taro meal, pumpkin powder, oranges, bananas, duck meat, black fungus, tomatoes, grapes, mulberry, longan pulp, litchi, black soya bean, vitamin premix and trace element premix. The dog food disclosed by the invention has the beneficial effects that the dog food contains traditional Chinese medicine additives with the functions of nourishing yin to lessen fire, cooling blood and eliminating toxins, and tonifying qi and strengthening the body resistance; when the dog food containing the traditional Chinese medicine additives is specifically used for treating the dog thyroid function hyperthyroidism, the dog food has the advantage of specific treatment effect, super quality and competitive price, high safety, high suitability, no drug residue, shorter treatment course, better curative effect, no tolerance, low cost and the like.

The invention provides pharmaceutical compositions for improving the bone loss of hyperthyroid high-conversion type and the reduction of the biomechanical properties of the bone, and relates to an extract of a Chinese medicinal Danshen, or the formula and the production process of pharmaceutical compositions for improving the bone loss of high-conversion type and the reduction of the biomechanicalproperties of the bone caused by the hypersplenism of the thyroid, which is prepared from the following components in parts by weight: 0.1 to 0.3 g of a danshensu and 5 g of crystalline fructose, thepharmaceutical compositions are characterized by being prepared into an injection. The invention further discloses a formula and production process of the injection, a granule and a non-alcoholic beverage. The high-dose thyroxine-induced hyperthyroid high-conversion bone loss animal model proves that the pharmaceutical composition prepared from the danshensu and the fructose can influence the bone metabolism of the rat, promote the bone formation, inhibit the bone resorption, increase the bone mass, improve the bone mineral density and the bone mineral salt content, and improve the performance of the bone biomechanics, and has a good preventive effect on the damage of the bone biological biomechanical properties of the hyperthyroid osteoporosis.

The invention relates to an injection medicament for treating hyperthyroid, which comprises the following components by weight part: 2 to 5 milligrams of dexamethasone injection, 0.5 to 1 milligram of octreotide injection, and 10 to 20 milligrams of ciclosporin A. Immune preparations such as the dexamethasone injection, the octreotide injection, the ciclosporin A and the like are adopted for treating the hyperthyroid by locally injecting the thyroid, the volume of the tumid thyroid is remarkably shrunk, and the function of the thyroid basically recovers within two months, so the injection medicament has remarkable curative effect, and can remarkably improve the remission rate of hyperthyroid and reduce the rate of relapse. Serious abnormal change, hypothyroidism and parathyroid hypofunction are not caused, and laryngeal recurrent nerve injury is also not caused. Through more than 580 cases of clinical therapy in related hospitals, the volume of the tumid thyroid is remarkably shrunk after therapy, clinical symptoms disappear, allergic response and complications are not caused, the effective percentage is nearly 100 percent, and the cure rate is as high as 98 percent.

The invention discloses application of jade lady variant decoction in preparing a medicament for treating hyperthyrea symptom. The invention also discloses application of the jade lady variant decoction in preparing a medicament for treating hyperthyroid heart disease relevant to the hyperthyrea symptom. The jade lady variant decoction can be complementary with the prior chemical medicament in a hyperthyrea treatment mechanism, can be synergized with the chemical medicament in clinical application so as to reduce the consumption of the chemical medicament and possibly becomes a valuable substituent treatment means for patients who cannot tolerate the adverse reaction of the chemical medicament. The application provides new valuable experimental evidence for developing new Chinese medicament for treating the hyperthyrea symptom and the hyperthyroid heart disease relevant to the hyperthyrea symptom.

Hashimoto's Thyroiditis (HT) is the most common type of inflammation of the thyroid gland and accurate diagnosis of HT would be advantageous in predicting thyroid failure. The application presents a three tier architecture for image-based diagnosis and a monitoring application using a network cloud. The presentation layer is run on the tablet (e.g., a mobile device), while the business and persistence layers run on a single network cloud or distributed on different network clouds in a multi-tenancy and multi-user application. Such three tier architecture is used for automated data mining application for diagnosis of Hashimoto's Thyroiditis (HT) Disease using ultrasound.

The invention discloses a micro-fluidic chemiluminescence detecting system for magnetic particles for detecting thyroid functions. The system comprises a bottom plate and an upper chip, and the upperchip comprises a sample adding area in the center of the upper chip and five micro-fluidic reaction detecting channels communicated with the sample adding area, wherein the five micro-fluidic reactiondetecting channels include a total triiodothyronine micro-fluidic reaction detecting channel, a total thyroxine micro-fluidic reaction detecting channel, a free triiodothyronine micro-fluidic reaction detecting channel, a free thyroxine micro-fluidic reaction detecting channel and a thyroid stimulating hormone micro-fluidic reaction detecting channel. In application of the system, the bottom plate is arranged under the upper chip, and magnets which are permanent magnets or electromagnets are arranged at positions, corresponding to magnetic particle coating areas of the micro-fluidic reactiondetecting channels, of the bottom plate. By ingenious combination of the micro-fluidic technology and the magnetic particle chemiluminescence technology, quickness, high sensitivity and accuracy in quantitative detection of target substances are realized.