5 results about "Thyrotropin receptor" patented technology

The present application relates to the field of bioengineering, and particularly relates to a mutant of thyroid stimulating hormone receptor and a preparation method and application thereof. The present application provides a mutant of thyroid stimulating hormone receptor, wherein one or more of the 321st-360th amino acids of the wild-type amino acid of the thyroid stimulating hormone receptor are deleted. The mutant provided by the present application improves the stability of the protein, improves the temperature sensitivity, and improves the gradient and potency and other functions, and does not change the ability of binding with enzyme-labeled antibodies and autoantibodies.

The present application provides a novel compound having a thyroid stimulating hormone receptor antagonistic activity, which is useful for treating thyroid-related diseases. The present application relates to a biaryl compound represented by the following formula (I) or a pharmacologically acceptable salt thereof. The compound of the present application or a pharmacologically acceptable salt thereof has an antagonistic activity against a thyroid stimulating hormone receptor, and is thus useful as a therapeutic agent for thyroid-related diseases (e.g., hyperthyroidism, Graves' disease, thyroid eye disease, and thyroid cancer), and the like.

The present invention addresses the problem of providing a novel compound that has an antagonistic activity against a thyroid-stimulating hormone receptor and is useful for the treatment of thyroid-related diseases. The present invention relates to an N-substituted piperidone compound represented by the following formula or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof according to the present invention has an antagonistic activity against a thyroid-stimulating hormone receptor and is useful, for example, as a therapeutic agent for thyroid-related diseases (e.g., hyperthyroidism, Graves' disease, thyroid eye disease, and thyroid cancer).

The present application provides a novel compound having a thyroid stimulating hormone receptor antagonistic activity, which is useful for treating thyroid-related diseases. The present application relates to a nitrogen-containing fused ring compound represented by the following formula (A-I) or a pharmacologically acceptable salt thereof. The compound of the present application or a pharmacologically acceptable salt thereof has an antagonistic activity against a thyroid stimulating hormone receptor, and is thus useful as a therapeutic agent for thyroid-related diseases (e.g., hyperthyroidism, Graves' disease, thyroid eye disease, and thyroid cancer), and the like.