309 results about "Hyperthyroidism/thyrotoxicosis" patented technology

The composition of the present invention is geared towards treating hyperhidrosis or any condition involving and / or promoting excessive sweating, typically involving the whole body, include hyperthyroidism or similar endocrine disorders; endocrine treatment for prostatic cancer or other types of malignant disorder; severe psychiatric disorders; obesity and menopause. The foamable composition of the present invention is suitable for treating palmar hyperhidrosis; axillary hyperhidrosis; plantar hyperhidrosis; hyperhidrosis of the trunk and / or the thighs; and facial hyperhidrosis; and any combination of them consisting of a therapeutic foamable composition including: an active agent, suitable for the treatment or prevention of hyperhidrosis.

The invention discloses a clinical data mining analysis and aided decision-making method based on an Internet integrated medical platform, and relates to the technical field of an Internet medical platform. The clinical data mining analysis and aided decision-making method includes data mining analysis and aided decision-making, wherein data mining analysis includes a multidimensional analysis algorithm module, a data mining algorithm module and a deep learning algorithm module; and aided remote decision-making includes four parts: a prediction module based on index parameters, a prediction module based on inspection report texts, a model training module and a structurized module. The clinical data mining analysis and aided decision-making method based on an Internet integrated medical platform selects several diseases as research objects for data collection and analysis, such as hyperthyroidism, diabetes, thyroid nodules and breast tumors, and collects and integrates clinical medicaldata depended the integrated platform to realize data mining analysis and aided decision-making services for clinical data diseases, such as hyperthyroidism, diabetes, thyroid nodules and breast tumors, so as to provide systematic support for clinical diagnosis of clinicians and disease research by researchers.

The composition of the present invention is geared towards treating hyperhidrosis or any condition involving and / or promoting excessive sweating, typically involving the whole body, include hyperthyroidism or similar endocrine disorders; endocrine treatment for prostatic cancer or other types of malignant disorder; severe psychiatric disorders; obesity and menopause. The foamable composition of the present invention is suitable for treating palmar hyperhidrosis; axillary hyperhidrosis; plantar hyperhidrosis; hyperhidrosis of the trunk and / or the thighs; and facial hyperhidrosis; and any combination of them consisting of a therapeutic foamable composition including: an active agent, suitable for the treatment or prevention of hyperhidrosis.

The composition of the present invention is geared towards treating hyperhidrosis or any condition involving and / or promoting excessive sweating, typically involving the whole body, include hyperthyroidism or similar endocrine disorders; endocrine treatment for prostatic cancer or other types of malignant disorder; severe psychiatric disorders; obesity and menopause. The foamable composition of the present invention is suitable for treating palmar hyperhidrosis; axillary hyperhidrosis; plantar hyperhidrosis; hyperhidrosis of the trunk and / or the thighs; and facial hyperhidrosis; and any combination of them consisting of a therapeutic foamable composition including: an active agent, suitable for the treatment or prevention of hyperhidrosis.

The composition of the present invention is geared towards treating hyperhidrosis or any condition involving and / or promoting excessive sweating, typically involving the whole body, include hyperthyroidism or similar endocrine disorders; endocrine treatment for prostatic cancer or other types of malignant disorder; severe psychiatric disorders; obesity and menopause. The foamable composition of the present invention is suitable for treating palmar hyperhidrosis; axillary hyperhidrosis; plantar hyperhidrosis; hyperhidrosis of the trunk and / or the thighs; and facial hyperhidrosis; and any combination of them consisting of a therapeutic foamable composition including: an active agent, suitable for the treatment or prevention of hyperhidrosis.

The present invention relates to furanopyridine compounds having the general Formula I: and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of modulating Lck and ACK-1 enzymes and of treating various related diseases and conditions, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, comprising administering to the mammal a therapeutically effective amount a compound of Formula I, as described above, and methods of manufacturing medicaments comprising the compound of Formula I.

This invention relates to a method for treating or preventing hyperthyroidism associated with aging and / or with Aging-Related Vitamin D Deficiency (ARVDD) syndrome by administering a sufficient amount of an active vitamin D compound utilizing a variety of effective treatment protocols. The invention further relates to treating or preventing one or more of the following conditions, e.g., (1) primary vitamin D deficiency, (2) 1,25-(OH)2D3 deficiency, and (3) 1,25-(OH)2D3 resistance included within the syndrome of ARVDD.

The invention belongs to the technical field of immunodiagnosis, and discloses a thyroxine (T4) enzymatic chemiluminescence quantitative determination kit. The kit disclosed by the invention consists of a T4 standard product, an antibody pre-coated reaction plate, a horseradish peroxidase marker, diluent, cleaning mixture, and chemiluminescence substrate liquid. The kit disclosed by the invention has the advantages of quickness, handiness, sensitiveness, cheapness and high repeatability, and is an important index for diagnosis and therapeutic evaluation of hyperthyroidism and hypothyroidism. The invention has high clinic use value. The invention also provides a method to prepare the kit.

The aquogel type thiamazole plaster includes a back lining layer, a medicine matrix layer and a protecting film. The medicine matrix layer contains medicine thiamazole in 0.2-20 wt% of the medicine matrix layer, aquogel type contact adhesive material, cross-linking agent, pH regulator, humectant, tackifier medicine, transdermal promoter and water, . The present invention has high transdermal effect of medicine, good skin compatibility, high air and moisture permeability, lowered toxicity and side effect of medicine and other advantages, and is used for treating hyperthyroidism.

A traditional Chinese medicine composition for treating hyperthyroidism and a preparation method and a use method thereof resolve the problem that the existing traditional Chinese medicine for treating hyperthyroidism does not have common adaptability and is not favorable for industrial production. The composition comprises the following raw materials as effective components: 15-60 parts of astragalus mongholicus, 15-50 parts of radix scrophulariae, 15-60 parts of oyster, 15-50 parts of thunberg fritillary bulb and 10-60 parts of selfheal. The composition changes composition ratio of the raw material medicine according to difference of clinical symptoms of hyperthyroidism, thereby being suitable for the front stage, the middle stage and the later stage of the hyperthyroidism. The composition adopts the start point design- response surface method to optimize process parameter extracted from the effective components of the raw material medicine. The traditional Chinese medicine composition is based on heteropathy in the whole generation and development processes of the disease and has the advantages of being quick, good and high in treatment effect, small in side effect, convenient to take and the like. The disease is not apt to reappear by means of the composition.

A Chinese medicine for treating thyroidism by interior application is prepared from 18 Chinese-medicinal materials including Chinese angelica root, cyprus tuber, tuckahoe, yam, etc through preparing honeyed pills.

The present invention relates to furanopyrimidine compounds having the general Formula I: and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of treating various diseases and conditions in a mammal, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma and thymoma, comprising administering to the mammal a therapeutically effective amount of a compound of Formula I. The invention also relates to methods of manufacturing medicaments, which comprise one or more compounds of Formula I.

The invention relates to a content determination and identification method of hyperthyroidism resistance powder, which pertains to the technical field of traditional Chinese medicine and particularly relates to measurement and identification method of component content in Chinese medicine preparation. The quality control method comprises the methods of: measuring the content of hesperidin with the chemical formula of C28H34O15 in a medicament by a high performance liquid chromatography (HPLC) method and identifying the following components such as corydalis ambigua, fructus ligustri lucidi, alpha-cyperone and paeoniflorin in the medicament by a thin-layer chromatography (TLC) method. The content determination and identification method for hyperthyroidism resistance powder has the advantages of overcoming the shortage of traditional Chinese medicine, establishing an advanced quality control method for the medicament, utilizing the HPLC method to measure the content of the hesperidin in the medicament and conducting TLC identification on the main components such as the corydalis ambigua, the fructus ligustri lucidi, the alpha-cyperone and the paeoniflorin and the like in the medicament, thus ensuring the accuracy and advancement of the medicament content determination and identification method.

The invention discloses a medicament for treating hyperthyroidism and a preparation method thereof. The medicament for treating hyperthyroidism of the invention is mainly prepared from the following raw material in part by weight: 300 to 500 parts of common selfheal fruit-spike, 200 to 400 parts of figwort root, and 200 to 300 parts of airpotato yam rhizome. The raw materials also include 200 to 400 parts of rhizoma bolbostemmae and / or 500 to 700 parts of raw oyster. Preferably, the medicament is prepared from the following raw materials in part by weight: 400 parts of common selfheal fruit-spike, 300 parts of figwort root, 240 parts of airpotato yam rhizome, 300 parts of rhizoma bolbostemmae and 600 parts of raw oyster. The medicament can be formed into any pharmaceutical formulation. The formulation is capsules. The medicament of the invention has the functions of nourishing yin, suppressing yang, detoxifying, eliminating goiter, reducing phlegm and resolving masses. The medicament can treat hyperthyroidism and is agreeable with patients incapable of bearing western medicaments.

The invention relates to a medicine for curing hyperthyroidism and a method of preparing the medicine. The medicine is composed of 10 to 40 portion of fresh yam, 10 to 40 portion of raw oyster, 10 to 40 portion of fortune's drynaria rhizome, 10 to 40 portion of milkvetch root, 10 to 40 portion of pumice, 10 to 40 portion of climbing groundsel herb, 10 to 40 portion of spicaprunellae, 10 to 40 portion of sargassum, 10 to 40 portion of thallus eckloniae, 10 to 40 portion of white mustard seed, 5 to 20 portion of thunberg fritillary bulb, 5 to 20 portion of tuber pinelliak, 5 to 20 portion of angelica, 5 to 20 portion of ampelopsis japonica, 5 to 20 portion of pipewort, 5 to 20 portion of tangshen, 5 to 20 portion of trigone, 5 to 20 portion of rhizoma zedoariae, 2 to 8 portion of cyclophosphamide and 0.3 to 1 portion of tapazole by the weight percent, which are processed through a series of procedures, including medicine selection, drying arrow crushing, sifting arrow sterilization arrow preparation and packaging. The invention is characterized by quick effect, short period of treatment, high therapeutic effect, little toxicity and side effect, convenience in being taken and prevention of recurrence, etc.

The invention relates to compositions for preventing and / or treating cardiovascular diseases in felines with hyperthyroidism wherein the compositions comprise from about 0.07 to less than about 1 mg / kg iodine and / or from about 0.1 to about 1.3 mg / kg selenium. The invention also relates to methods for preparing and using such compositions. articles of manufacture comprising such compositions, and means for communicating information about such compositions. methods, and articles of manufacture.

Methods for treating feline hyperthyroidism comprising (1) administering to a feline an antithyroid agent in conjunction with feeding the feline a composition comprising from about 0.1 to less than about 1 mg / kg iodine or (2) feeding the feline a composition comprising from about 0.1 to less than about 1 mg / kg selenium on a dry matter basis.

The invention relates to a medicinal preparation for treating thyroid gland hyperfunction and process for its preparation, wherein raw materials include (by weight proportion) rough gentian, seabuckthorn fruit, selfheal and cape jasmine.

The invention relates to compositions for preventing chronic renal failure (CRF) in felines with hyperthyroidism wherein the compositions comprise (1) from about 28 to about 35% protein, the protein comprising at least about 75% vegetable protein, and (2) from about 0.1 to less than about 1 mg / kg iodine and / or from about 0.1 to about 1 mg / kg selenium. The invention also relates to compositions for treating CRF in hyperthyroid felines wherein the compositions comprise (1) from about 28 to about 35% protein, the protein comprising at least about 75% vegetable protein, and (2) from about 0.1 to less than about 0.3 mg / kg iodine and / or from about 0.1 to about 1 mg / kg selenium. The invention further relates to methods for preparing and using such compositions, articles of manufacture comprising such compositions, and means for communicating information about such compositions, methods, and articles of manufacture.

The invention discloses a traditional Chinese medicine preparation used for treating hyperthyroidism. The hyperthyroidism belongs to the categories of goiter and palpitation in the traditional Chinese medicine science. Basic pathogenesis comprises stagnation of liver qi, fire transformation owning to depression, qi and fluid loss, phlegmostagnant blood stasis, overstrain and deficiency of qi and yin due to impairment spleen and qi consumption owning to liver fire. Thus, traditional Chinese medicines abrus herb, fiveleaf akebia fruit, persian veronica, selenitum, dried rehamnnia root, asparagus fern, ophiopogon latifolius, cortex albiziae, tree falsespiraea bark, cornu procaprae gutturosae, concha ostreae, airpotato yam rhizome and clausena lansium kernel are selected and prepared into an orally taken decoction by a medicine preparation room of a hospital (described in the specification), clinical test shows that the total effective rate is 97.2%, and indicators of each treatment group are respectively obviously improved.

A medicine for treating various diseases such as women's climacteric syndrome, osteoporosis, mental depression, premature ovarian failure, premenstrual tension syndrome, hyperthyroidism, male and female infertility, hair loss and white hair, and is characterized in that it It is composed of fatty acids in the following weight percent range: hexadecanoic acid 8-32%, hexadecenoic acid 11-35%, octadecenoic acid 13-33%, octadecanoic acid 0.3-2.5%, octadecanoic acid Carbadienoic acid 11-33%, octadecatrienoic acid 3-15%. Compared with other drugs, the drug composition is simple, belongs to the target organ agonist, and has an independent reversible regulation function on the second messenger of the body. It is a medicine with high curative effect, safety and simplification.

An interior-applied Chinese medicine for treating thyroidism is prepared from 16 Chinese-medicinal materials including white peony root, mulberry fruit, cyprus tuber, red sage root, etc.

The present invention relates to an antipruritic agent comprising a nociceptin antagonist as an active ingredient. The nociceptin antagonist can be used as a preventive or remedy for diseases associated with itching (for example, atopic dermatitis and urticaria), local pruritus cutaneous caused by insect excretion and secretion, nodular prurigo, kidney dialysis, diabetes, blood disease, liver disease, kidney disease, incretion and metabolic disorder, viscera malignant tumor, hyperthyroidism, autoimmune disease, multiple sclerosis, neurologic disease, psychoneurosis, allergic conjunctivitis, spring catarrh, atopic keratoconjunctivitis, or itching caused by excess use of laxuries and drugs because it has excellent scrtaching behavior suppressing effect, that is, antiitching effect and antipruritic effect.

The invention relates to a method for quantitatively detecting TRAb plate-type fluorescent enzyme immunity and an application thereof. The method is characterized in that recombination human thyroxin stimulating hormone receptor (hTSHR) extracellular domain amino terminal proteins is taken as antigen to coat a perforated plate and then is sealed by PBST containing 1-5% of BSA; anti-hTSHR first antibody or standard substance, enzyme-labeled second antibody, fluorescent substrate and stopping solution are sequentially added by utilizing the perforated plate as a carrier; and finally fluorescence intensity is measured on a fluorescence illuminant analyzer. The clinical detection of TRAb which mainly comprises TSAb in patient serum has great significance on pathogenic diagnosis, curative effect observation and drug withdrawal occasion determination of GD hyperthyroidism. The invention performs the fluorescence enzyme immunoassay by utilizing a multi-hole site plastic plate as a solid carrier, has easy sheet material source, low cost and easy promotion, and the method is distinctive, sensitive, accurate and stable, thereby being suitable for clinical requirement and promotion.

The invention discloses an intelligence-benefiting and brain-tonifying sesame oil. The intelligence-benefiting and brain-tonifying sesame oil is prepared from the following raw materials in parts by weight: 300-320 parts of black sesame, 100-120 parts of walnut, 100-120 parts of pumpkin, 50-60 parts of ginseng, 50-60 parts of buckwheat, 50-60 parts of sunflower seed, 30-40 parts of raw white peony root, 20-50 parts of donkey-hide gelatin, 30-40 parts of raw tortoise plastron, 40-50 parts of raw oyster, 5-6 parts of dried rehmannia, 6-7 parts of edestan, 4-5 parts of schisandra chinensis, 5-7 parts of dwarf lilyturf tuber, 5-7 parts of egg yolk, 5-7 parts of raw turtle shell and the like, wherein as main auxiliary materials, the walnut has a brain-tonifying effect, and the ginseng has mind-tranquilizing and intelligence-benefiting effects; the raw white paeony root, the dried rehmannia and the dwarf lilyturf tuber have the effects of nourishing Yin and liver, nourishing kidney and liver, and moistening dryness and relieving impatience; the raw tortoise plastron, the raw turtle shell and the raw oyster have the effects of nourishing Yin and suppressing Yang; the edestan is moist in texture and rich in grease, and has the effects of nourishing Yin and moistening dryness; the schisandra chinensis is sour, and is good at restraining real Yin; the egg yolk and the donkey-hide gelatin are flesh and blood nourishing products, and have the effects of nourishing Yin fluid to suppress endogenous wind and the like; therefore, the intelligence-benefiting and brain-tonifying sesame oil provided by the invention is endowed with certain health-care functions. After long-time use, the intelligence-benefiting and brain-tonifying sesame oil can improve the intelligence, relieve brain fatigue, and prevent high blood pressure, cerebrovascular disease sequelae, hyperthyroidism symptoms and other diseases.

The invention provides a 2,4-dibenzyloxybenzoic acid derivative shown by a formula (I) or pharmaceutically acceptable salts thereof, and also provides a preparation method of the 2,4-dibenzyloxybenzoic acid derivative or pharmaceutically acceptable salts thereof and an application thereof in preparing a medicine for treating cardiovascular and cerebrovascular diseases, tumors, diabetes mellitus, nephrosis, asthma or hyperthyroidism.

This invention describes monoclonal antibodies that suppress thyrotropin receptor constitutive activity and methods of using the antibodies to treat thyroid related diseases; particularly hyperthyroidism and thyroid cancer

This invention discloses an indicator paper for thyrotropin diagnosis, which comprises one testing area, one normal high limit control area, one normal low limit control area and a gold immune complex dry area. This invention also discloses the application of the indicator paper for thyrotropin diagnosis. It is a regular testing method to judge hypothalamus- hypophysis-thyroid axis function. This invention can be also used in the following fields: screening primary thyroid dysfunction such as hypothyroidism and hyperthyroidism; thyroid hormone substitution and abatement therapeutic efficacy detecting; hyperthyroidism and hypothyroidism patient diagnosis; thyroid function monitoring of iodine-assisting crowd and thyroid dysfunction of non-thyroid continuous monitoring.

The invention discloses a medicine for treating hyperthyroidism and a preparation method thereof. The medicine is prepared from the following components according to a certain weight ratio: flos mume, air potato, dens draconis, white hyacinth bean, radices stellariae dichotomae, smoked plum, cortex albiziae and kelp. The medicine has the effects of promoting blood circulation to remove blood stasis, clearing away heat and toxic materials and diminishing swelling and removing stasis, is used for treating hyperthyroidism and is fast in effect, good in curative effect and high in cure rate.

The present invention relates to a pharmaceutical composition for preventing or treating thyroid diseases and a food composition for improving thyroid function, comprising an extract from Lonicera caerulea L. car. Edulis fruits as an active ingredient.The composition of the present invention may be useful for preventing or treating thyroid diseases such as hypothyroidism, hyperthyroidism, thyroid nodule, or thyroditis, and improving thyroid function. Since the extract from Lonicera caerulea L. car. Edulis fruits, which is an active ingredient of the present invention, is derived from natural products, there is no concern for side effects such as toxicity compared to synthetic medicine.