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5 results about "Hyperthyroidism/thyrotoxicosis" patented technology
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Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormone by the thyroid gland. Thyrotoxicosis is the condition that occurs due to excessive thyroid hormone of any cause and therefore includes hyperthyroidism. Some, however, use the terms interchangeably.
Bicyclo [1.1.1] pentane compounds
To provide a new compound having thyroid stimulating hormone receptor antagonist activity and useful for treating thyroid-related diseases.SOLUTION: The present invention relates to a bicyclo [1.1.1] pentane compound represented by the following formula (I) or a pharmacologically acceptable salt thereof. Since the compound of the present invention or a pharmaceutically acceptable salt thereof has an antagonist activity against a thyroid stimulating hormone receptor, it is useful as a therapeutic agent for thyroid-related diseases (e.g., hyperthyroidism, Graves' disease, thyroid ophthalmopathy and thyroid cancer) and the like.SELECTED DRAWING: None
![Bicyclo [1.1.1] pentane compounds](https://images-eureka.patsnap.com/patent_img/38f00af2-5a02-47d7-b049-bdbee8e44719/2026006064000001.png "Bicyclo [1.1.1] pentane compounds")
![Bicyclo [1.1.1] pentane compounds](https://images-eureka.patsnap.com/patent_img/38f00af2-5a02-47d7-b049-bdbee8e44719/2026006064000002.png "Bicyclo [1.1.1] pentane compounds")
![Bicyclo [1.1.1] pentane compounds](https://images-eureka.patsnap.com/patent_img/38f00af2-5a02-47d7-b049-bdbee8e44719/2026006064000003.png "Bicyclo [1.1.1] pentane compounds")
Owner:KISSEI PHARMACEUTICAL CO LTD
Di-substituted bicyclo[1.1.1]pentane compound
The present invention addresses the problem of providing a novel compound that has an antagonistic activity against thyroid-stimulating hormone receptors and is useful for the treatment of thyroid-related diseases. The present invention relates to a di-substituted bicyclo[1.1.1]pentane compound represented by formula (I) or a pharmacologically acceptable salt thereof. The compound or the pharmacologically acceptable salt thereof according to the present invention has an antagonistic activity against thyroid-stimulating hormone receptors and is useful as, for example, a therapeutic agent for thyroid-related diseases (e.g., hyperthyroidism, Graves' disease, thyroid eye disease, and thyroid cancer).
![Di-substituted bicyclo[1.1.1]pentane compound](https://images-eureka.patsnap.com/patent_img/6eb2d187-ad3d-4763-bda0-0aee91a595e9/JP2025022961_02012026_pf_fp.png "Di-substituted bicyclo[1.1.1]pentane compound")
Owner:KISSEI PHARMACEUTICAL CO LTD
N-substituted piperidone compound
The present invention addresses the problem of providing a novel compound that has an antagonistic activity against a thyroid-stimulating hormone receptor and is useful for the treatment of thyroid-related diseases. The present invention relates to an N-substituted piperidone compound represented by the following formula or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof according to the present invention has an antagonistic activity against a thyroid-stimulating hormone receptor and is useful, for example, as a therapeutic agent for thyroid-related diseases (e.g., hyperthyroidism, Graves' disease, thyroid eye disease, and thyroid cancer).
Owner:KISSEI PHARMACEUTICAL CO LTD
Nitrogen-containing fused ring compounds
The present application provides a novel compound having a thyroid stimulating hormone receptor antagonistic activity, which is useful for treating thyroid-related diseases. The present application relates to a nitrogen-containing fused ring compound represented by the following formula (A-I) or a pharmacologically acceptable salt thereof. The compound of the present application or a pharmacologically acceptable salt thereof has an antagonistic activity against a thyroid stimulating hormone receptor, and is thus useful as a therapeutic agent for thyroid-related diseases (e.g., hyperthyroidism, Graves' disease, thyroid eye disease, and thyroid cancer), and the like.
Owner:KISSEI PHARMACEUTICAL CO LTD