6 results about "Hyperthyroidism/thyrotoxicosis" patented technology

The invention provides a pharmaceutical composition for treating hyperthyroidism and application of the pharmaceutical composition, core active ingredients are prunella vulgaris extract, thunberg fritillary bulb alkaloid, methimazole / propylthiouracil, selenomethionine, curcumin and prebiotics, and vitamin E and sodium carboxymethyl cellulose can be added as auxiliary ingredients. During preparation, the stability and uniformity of the components are ensured through the processes of curcumin inclusion, inert gas step-by-step mixing, high-speed shearing dispersion, vacuum freeze drying and the like. According to the composition, through the synergistic effect of multiple components, FT3 and FT4 levels are remarkably reduced, TSH is adjusted, the curative effect is better than that of single chemical medicine and a conventional formula, gastrointestinal irritation and liver injury can be reduced, and the composition is suitable for treating hyperthyroidism and particularly has the outstanding effects on improving symptoms and improving safety.

To provide a new compound having thyroid stimulating hormone receptor antagonist activity and useful for treating thyroid-related diseases.SOLUTION: The present invention relates to a bicyclo [1.1.1] pentane compound represented by the following formula (I) or a pharmacologically acceptable salt thereof. Since the compound of the present invention or a pharmaceutically acceptable salt thereof has an antagonist activity against a thyroid stimulating hormone receptor, it is useful as a therapeutic agent for thyroid-related diseases (e.g., hyperthyroidism, Graves' disease, thyroid ophthalmopathy and thyroid cancer) and the like.SELECTED DRAWING: None

The present invention addresses the problem of providing a novel compound that has an antagonistic activity against thyroid-stimulating hormone receptors and is useful for the treatment of thyroid-related diseases.　The present invention relates to a di-substituted bicyclo[1.1.1]pentane compound represented by formula (I) or a pharmacologically acceptable salt thereof. The compound or the pharmacologically acceptable salt thereof according to the present invention has an antagonistic activity against thyroid-stimulating hormone receptors and is useful as, for example, a therapeutic agent for thyroid-related diseases (e.g., hyperthyroidism, Graves' disease, thyroid eye disease, and thyroid cancer).

The present invention addresses the problem of providing a novel compound that has an antagonistic activity against a thyroid-stimulating hormone receptor and is useful for the treatment of thyroid-related diseases. The present invention relates to an N-substituted piperidone compound represented by the following formula or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof according to the present invention has an antagonistic activity against a thyroid-stimulating hormone receptor and is useful, for example, as a therapeutic agent for thyroid-related diseases (e.g., hyperthyroidism, Graves' disease, thyroid eye disease, and thyroid cancer).

The present application provides a novel compound having a thyroid stimulating hormone receptor antagonistic activity, which is useful for treating thyroid-related diseases. The present application relates to a nitrogen-containing fused ring compound represented by the following formula (A-I) or a pharmacologically acceptable salt thereof. The compound of the present application or a pharmacologically acceptable salt thereof has an antagonistic activity against a thyroid stimulating hormone receptor, and is thus useful as a therapeutic agent for thyroid-related diseases (e.g., hyperthyroidism, Graves' disease, thyroid eye disease, and thyroid cancer), and the like.