The invention discloses an intelligence-benefiting and brain-tonifying sesame oil. The intelligence-benefiting and brain-tonifying sesame oil is prepared from the following raw materials in parts by weight: 300-320 parts of black sesame, 100-120 parts of walnut, 100-120 parts of pumpkin, 50-60 parts of ginseng, 50-60 parts of buckwheat, 50-60 parts of sunflower seed, 30-40 parts of raw white peony root, 20-50 parts of donkey-hide gelatin, 30-40 parts of raw tortoise plastron, 40-50 parts of raw oyster, 5-6 parts of dried rehmannia, 6-7 parts of edestan, 4-5 parts of schisandra chinensis, 5-7 parts of dwarf lilyturf tuber, 5-7 parts of egg yolk, 5-7 parts of raw turtle shell and the like, wherein as main auxiliary materials, the walnut has a brain-tonifying effect, and the ginseng has mind-tranquilizing and intelligence-benefiting effects; the raw white paeony root, the dried rehmannia and the dwarf lilyturf tuber have the effects of nourishing Yin and liver, nourishing kidney and liver, and moistening dryness and relieving impatience; the raw tortoise plastron, the raw turtle shell and the raw oyster have the effects of nourishing Yin and suppressing Yang; the edestan is moist in texture and rich in grease, and has the effects of nourishing Yin and moistening dryness; the schisandra chinensis is sour, and is good at restraining real Yin; the egg yolk and the donkey-hide gelatin are flesh and blood nourishing products, and have the effects of nourishing Yin fluid to suppress endogenous wind and the like; therefore, the intelligence-benefiting and brain-tonifying sesame oil provided by the invention is endowed with certain health-care functions. After long-time use, the intelligence-benefiting and brain-tonifying sesame oil can improve the intelligence, relieve brain fatigue, and prevent high blood pressure, cerebrovascular disease sequelae, hyperthyroidism symptoms and other diseases.