Human monoclonal antibodies to the thyrotropin receptor which act as antagonists
A thyroid-stimulating hormone and thyroid technology, applied in the direction of anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, antibody, anti-animal/human immunoglobulin, etc.
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Embodiment 1
[0199] Sample
Embodiment 2
4131±776
[0203] 1 Average of duplicate samples
[0204] 2G4=Control IgG (human MAb against thyroid peroxidase).
[0205] The antibody and TSH preparations are diluted in cyclic AMP assay buffer.
[0206] Table 2c
[0207] The effect of 5C9 IgG and 9D33 IgG on the stimulation of cyclic AMP produced by TSH or M22Fab in CHO cells expressing human TSHR
[0208]
Cyclic AMP production
(fmol / cell well; mean±SD n=3)
Only cyclic AMP assay buffer
473±21
PTSH only 3ng / mL
12,270±980
Only 5C9 IgG 100μg / mL
426±27
Only 5C9 IgG 10μg / mL
360±53
Only 5C9 IgG 1μg / mL
376±18
Only 5C9 IgG 0.1μ / mL
404±42
Only 5C9 IgG 0.01μg / mL
578±65
Only 5C9 IgG 0.001μg / mL
554±47
5C9IgG 100μg / mL+pTSH 3ng / mL
1094±70
5C9 IgG 10μg / mL+pTSH 3ng / mL
1028±47
5C9 IgG 1μg / mL+pTSH 3ng / mL
1872±168
5C9 IgG 0.1μg / mL+pTSH 3ng / mL
3920±464
5C9 IgG 0.01μg / mL+pTSH 3ng / mL
15,050±386
5C9 IgG 0.001μg / mL+pTSH 3ng / mL
14,147±1,310
9D33 IgG only 100μg / mL
626±127
9D33 IgG 100μ...
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