Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Curtail hemagglutinin vaccine for preventing influenza virus and its preparing method

A technology for preventing influenza and influenza virus, which is applied in the field of truncated hemagglutinin vaccine and its preparation, can solve the problems of inability to overcome DNA vaccine cross-protection ability, influenza virus is easy to mutate, etc., and achieve no refrigeration, long-lasting immune response, avoid The effect of the stress response

Inactive Publication Date: 2005-06-29
WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, influenza virus is prone to mutations, and it still cannot overcome the problem of poor cross-protection ability of DNA vaccines

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Curtail hemagglutinin vaccine for preventing influenza virus and its preparing method
  • Curtail hemagglutinin vaccine for preventing influenza virus and its preparing method
  • Curtail hemagglutinin vaccine for preventing influenza virus and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0023] The invention is a truncated hemagglutinin vaccine for preventing influenza virus and a preparation method thereof.

[0024] The vaccines include: (1) truncated hemagglutinin nucleic acid vaccine for preventing influenza virus, that is, truncated HA DNA vaccine for preventing influenza virus. (2) A truncated hemagglutinin protein vaccine for the prevention of influenza virus.

[0025] The present invention will be further described below in conjunction with example and accompanying drawing.

[0026] 1. Truncated hemagglutinin vaccine against influenza virus

[0027] (1) Truncated HA DNA vaccine against influenza virus

[0028] 1. The vaccine component is the truncated A / PR / 8 / 34 influenza virus HA gene.

[0029] The full nucleotide sequence of the HA gene of A / PR / 8 / 34 influenza virus is shown in Figure 1: the full length is 1701 nucleotides, encoding a protein product with a size of 566 amino acids, and the nt1-nt825 fragment in the gene is the shortest protective seq...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the curtail hemagglutinin vaccine for preventing influenza virus and its preparing method, wherein the vaccine constituent is cropped A / PR / 8 / 34 influenza virus HA gene, the length of the A / PR / 8 / 34 influenza virus HA gene's encoding zone is 1701 nucleotides, and is encoded into a protein product of 566 amino acids, wherein the nt1-nt825 fragment is the shortest protection sequence, and the vaccine is obtained by replacing the full-length A / PR / 8 / 34 influenza virus HA gene with cropped A / PR / 8 / 34 influenza virus HA gene. In the invention, the A / PR / 8 / 34 influenza virus NA gene nucleotide total sequence is determined, the shortest protection sequence is also determined. The vaccine provided by the invention can induce the organism to develop long-lasting and comprehensive immune response.

Description

technical field [0001] The invention belongs to a biological product, in particular to a truncated hemagglutinin vaccine for preventing influenza virus and a preparation method thereof. Background technique [0002] Influenza virus is one of the main causes of human death. It can cause acute respiratory infection and seriously endanger human health and life. [0003] Hemagglutinin (HA) is the main surface antigen of influenza virus, which can induce the body to produce corresponding neutralizing antibodies to neutralize the virus. Influenza virus HA is encoded by RNA segment 4. Taking the A / PR / 8 / 34 (H1N1) strain as an example, its RNA segment 4 consists of 1765 nucleotides. The open reading frame (ORF) encodes 566 amino acids. HA is a typical class I membrane protein, and its primary structure contains four structural domains: signal peptide (leader sequence), cytoplasmic domain, transmembrane domain and extracellular domain. HA is inlaid on the viral envelope in the for...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/145A61K48/00A61P31/16
Inventor 陈则
Owner WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com