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Transmission system of drug for nasal cavity of containing trehalose and byaluronic acid, and preparation method

A delivery system, hyaluronic acid technology, applied in the field of medicine, can solve problems such as nasal stickiness and discomfort, achieve the effects of reducing toxic side effects, prolonging retention time, and reducing irritation

Inactive Publication Date: 2005-08-31
凌沛学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] Non-Newtonian fluid characteristics: Although synthetic high molecular polymers and other substances can increase the viscosity of the liquid medicine and prolong the residence time of the liquid medicine in the nasal mucosa to improve the curative effect, the synthetic high molecular polymer solution used is basically a Newtonian fluid. To a certain extent, it will make the inside of the nasal cavity feel sticky and uncomfortable

Method used

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  • Transmission system of drug for nasal cavity of containing trehalose and byaluronic acid, and preparation method
  • Transmission system of drug for nasal cavity of containing trehalose and byaluronic acid, and preparation method

Examples

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Embodiment 1

[0031] The nasal drug delivery system of the present invention contains 100 milliliters of trehalose 1.5 grams, sodium hyaluronate 0.10 grams, sodium chloride 0.70 grams, borax 0.05 grams, and the rest is purified water.

Embodiment 2

[0033] The nasal drug delivery system of the present invention contains 100 ml of trehalose 1.0 g, sodium hyaluronate 0.10 g, sodium chloride 0.75 g, borax 0.05 g, ethylparaben 0.03 g, and the rest is purified water.

Embodiment 3

[0035] The nasal drug delivery system of the present invention contains 100 ml of trehalose 1.5, sodium hyaluronate 0.10, chloramphenicol 0.68 g, sodium chloride 0.68 g, borax 0.05 g, ethylparaben 0.03 g, and the rest is purified water.

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PUM

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Abstract

A nasal medicine delivery system for preventing and treating various rhinitises, epistaxis, nasosinusitis, etc contains trehalose, hyaluronic acid and medicinal additive.

Description

Technical field: [0001] The invention belongs to the technical field of pharmaceuticals, and relates to a nasal drug delivery system (English: delivery system) containing trehalose (English: trehalose) and hyaluronic acid (English: hyaluronic acid, also known as hyaluronic acid) and a preparation method thereof. Background technique: [0002] Traditional nasal topical drug preparations have obvious disadvantages. For example, after the traditional nasal drops are instilled, the drug is quickly lost, which makes the drug bioavailability low and the effect is short. Even if the nasal drops are frequently used, sometimes it is difficult to achieve the desired effect. In addition, some nasal drops and nasal sprays also have disadvantages such as strong irritation or instability or high systemic absorption toxicity. These have restricted the application and development of traditional nasal medicine. In order to solve these problems, people hope to study and apply a nasal drug de...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K45/08A61K47/36A61P11/02
CPCA61K47/36A61K9/0043A61P11/02
Inventor 凌沛学荣晓花侯丽君张天民
Owner 凌沛学