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Limonene drop pills oral medicine for treating biliary passage disease and its preparation process

A technology of limonene and medicine, which is applied in the field of limonene drop pill medicine and its preparation, can solve the problems of poor airtightness, easy volatilization of limonene medicinal oil, and different grain content

Inactive Publication Date: 2006-07-19
成都和康药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of capsule, because each capsule contains a large amount of starch, its limonene content is limited, each time you need to take 3-5 capsules, the dosage is large, and the patient's compliance is poor
Also because the medicine granules in the capsule are formed by starch adsorption, the content of each granule may be uneven due to uneven adsorption, and the uniformity is poor; and because the capsule has gaps and poor airtightness, the limonene medicinal oil is easy to volatilize during storage, resulting in The effective content of the drug decreases, the curative effect becomes worse, or even unqualified, which affects the use of the drug; and its disintegration time is longer, usually more than 15 minutes, so the onset of effect is relatively slow

Method used

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  • Limonene drop pills oral medicine for treating biliary passage disease and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] According to the weight ratio of limonene: drop pill base 2: 1, add limonene into the drop pill base polyethylene glycol 4000 in molten state, mix evenly, and drop into drop pills under the condition of maintaining a constant temperature of 80±2°C , after cooling and drying.

Embodiment 2

[0014] According to the weight ratio of limonene: dripping pill base 1: 1.5, limonene is added to the dripping pill base polyethylene glycol 6000 in molten state, mix evenly, then add camphor and eucalyptus oil, stir, dissolve, and keep 80± Under the condition of a constant temperature of 2°C, it is made into dropping pills, cooled and dried.

Embodiment 3

[0016] According to the weight ratio of limonene: dripping pill base 1: 2.5, limonene is added to the dripping pill base vegetable oil in the molten state, mixed evenly, and dripped into dripping pills under the condition of maintaining a constant temperature of 75 ± 2 ° C, cooled, Serve dry.

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Abstract

The invention discloses a limonene medicinal drop pill for treating biliary tract diseases, wherein the existing dosage types for the conventional limonene preparations are modified to obtain drop pills with the advantages of simple process for manufacturing, shorter disintegration time, quicker action, better pharmaceutical stability, and longer effective period.

Description

technical field [0001] The invention relates to a limonene dropping pill medicine for treating biliary tract diseases and a preparation process thereof. Background technique [0002] Limonene is a kind of volatile oil obtained by cold-pressing the wet skin of Rutaceae orange. It is an orange-red transparent liquid with a specific aroma. It can be freely mixed with alcohol and ether. It is insoluble in water and has choleretic, stone-dissolving, Qi appetizing, anti-inflammatory, analgesic effect. [0003] Limonene capsules, which use limonene as the main component to treat biliary tract diseases, have been used clinically. After years of clinical verification, it has good curative effect, low recovery rate, and basically no toxic and side effects. However, the commonly used limonene capsule preparation in clinic is solid granular after the limonene medicated oil is adsorbed by starch, and then filled into a capsule composed of two capsule sleeves. S...

Claims

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Application Information

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IPC IPC(8): A61K31/015A61K9/20A61P1/16
Inventor 彭建坤
Owner 成都和康药业有限责任公司
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