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Composition for preventing and treating climacteric symptoms comprising the extract of sophorae fructus

A technology of active ingredients and compositions, applied in the field of compositions for the prevention and treatment of menopausal diseases, can solve the problems of carcinogenic risk of weight gain and the like

Inactive Publication Date: 2006-12-27
REXGENEBIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the above drugs are administered for a long period of time, there are disadvantages in that side effects such as risk of carcinogenesis, headache, weight gain, etc.

Method used

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  • Composition for preventing and treating climacteric symptoms comprising the extract of sophorae fructus
  • Composition for preventing and treating climacteric symptoms comprising the extract of sophorae fructus
  • Composition for preventing and treating climacteric symptoms comprising the extract of sophorae fructus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Manufacture of sophora japonicus extract

[0090] 20 kg of Huaijiao (Jesung Pharmaceutical Co., Ltd., Seoul Jingdong Market) was pulverized to a size of 30 meshes with a dry grinder. Drinking water was added to the pulverized product to dilute to 10 times (crushed product: drinking water = 9:1), and heated at 100° C. for 4 hours. Then, cool to 50° C., filter through a 100-mesh filter cloth, and then filter through a 200-mesh filter cloth to remove sediment and obtain a filtrate. The supernatant was concentrated to 1 / 5 volume with a concentrator to produce Sophora japonicus extract. In addition, this concentrated solution was spray-dried with a spray drier, and used for experiments after being made into powder.

Embodiment 2

[0092] Manufacture of enzymatically decomposed extract of Sophora japonicus

[0093] Filter the hot water extract of Sophorae japonicus produced by the method of the above-mentioned Example 1 with a filter cloth, add amylase to the obtained filtrate to make it reach a concentration of 0.5% (v / v), and carry out the enzyme reaction at 50°C for 16 Hour. The above-mentioned reaction solution was concentrated to 1 / 5 of the volume by a concentrator, thereby preparing an enzymatically decomposed extract of Sophora japonicus. In addition, this concentrated solution was spray-dried with a spray drier, and used for experiments after being made into powder.

Embodiment 3

[0095] Manufacture of food composition containing sophora japonicus extract

[0096] A food composition containing the sophocarps decomposed extract produced in Example 2 above was produced. Sophocarps decomposed extract 235g, non-plastic seaweed calcium powder 200g (Daedeok Pharmaceutical, Gyeonggi-do, South Korea) made by the method of above-mentioned embodiment 2, crystalline cellulose 27.5g (Daedeok Pharmaceutical, Gyeonggi-do, South Korea), milk Protein hydrolyzate 5g (Dynnatural, Seoul, South Korea), green tea extract powder 5g (Ming Foods, Gyeonggi-do, South Korea), shark cartilage extract powder 5g (Shinichi Trading Company, Seoul, South Korea), chitooligosaccharide 4g (YoungDeokChitosan Co.Ltd ., Seoul, South Korea), vitamin C5g (Roche Vitamin Co., Seoul, South Korea), collagen peptide (collagen peptide) 2.5g (Dynnatural, Seoul, South Korea), grape fruit extract powder 2.5g (Daedeok Pharmaceutical, Gyeonggi-do, South Korea ), enerzyme-P 2.5g (Sungchi Products, Gyeong...

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Abstract

The present invention relates to a composition for preventing and treating climacteric symptoms comprising the extract of Sophorae Fructus as an effective ingredient. Precisely, the present invention relates to the extract of Sophorae Fructus having an effect of preventing and treating climacteric symptoms, a composition comprising the extract and a method for preventing and treating climacteric symptoms by administering the composition. The extract of Sophorae Fructus of the present invention has activities of promoting the osteoblast proliferation, inhibiting the secretion of bone-absorptive cytokines, promoting the secretion of growth factors involved in bone-reformation, stimulating the generation of nitric oxide in osteoblasts and inhibiting the osteoclast differentiation. In addition, the extract also reduces the concentration of a bone absorption index and inhibits the decrease of calcium content and bone density. Therefore, the extract of Sophorae Fructus of the present invention can be effectively used for the prevention and the treatment of climacteric symptoms including osteoporosis.

Description

technical field [0001] The present invention relates to a composition for preventing and treating menopausal diseases containing Sophorae japonicus extract as an active ingredient. Specifically, the present invention relates to a Sophorae japonicus extract having preventive and therapeutic effects on climacteric diseases, a composition containing the sophora japonicus extract, and a method for preventing and treating climacteric diseases by administering the composition. Background technique [0002] Menopausal disease means a disease induced by a decrease in the secretion of male hormones or female hormones. Especially for women, due to the aging of the ovary, the secretion of estrogen is reduced, and the diseases that appear about 2 to 10 years before and after amenorrhea will induce high fever, sweating, insomnia, depression, urinary incontinence, pain, etc. Syndrome, osteoporosis, myocardial infarction, stroke and high blood pressure and other symptoms. [0003] Osteop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61P15/12A61K36/00A61P19/10
CPCA61K36/489A61P3/04A61P9/04A61P9/10A61P15/12A61P19/02A61P19/10A61P25/16A61P29/00
Inventor 权硕亨皇甫植金国焕李承桓尹银珠李承熙李民远李都翼崔永郁朱成洙元泰准姜熙哲
Owner REXGENEBIOTECH
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