Ophthalmic fluid
a technology of ophthalmic fluid and ophthalmic lipids, which is applied in the field of ophthalmic fluid, can solve the problems of keratoconjunctivitis and contact lens intolerance, dry eye syndrome, and reduced body's ability to produce lubricating lipids
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Examples
example 1
Triolein(1,2,3-tri(cis-9-octadecenoyl)glycerol) (Sigma Chemicals, 99%).
[0033] The subject reported that a gas permeable (hard) lens coated with triolein was very comfortable to insert, the edges of the lens seemingly smoothed out so as to reduce, but not totally eliminate, the normal discomfort associated when inserting a hard lens. Once inserted, the subject could not feel the presence of the coated lens. The subject's vision through the coated lens was excessively and persistently blurred. Excess triglyceride did not drain into the lacrimal ducts, and had to be physically removed.
[0034] The subject reported that a hydrogel (soft) lens coated with triolein was very difficult to insert, and did not noticeably ameliorate the normal discomfort associated when inserting a soft lens. The subject's vision through the coated lens was clear.
example 2
Trilinolein(1,2,3-tri(cis,cis-9,12-octadecadienoyl)glycerol) (Sigma Chemicals, 99%).
[0035] The subject reported that a gas permeable (hard) lens coated with trilinolein was very comfortable to insert. In comparison to a hard lens coated with triolein, however, the sensation caused by the edges of the lens on the eye was not reduced to the same extent by a hard lens coated in trilinolein. Once inserted, the subject could not feel the presence of the coated lens. The subject initially experienced blurred vision which cleared after approximately 60 seconds. Excess triglyceride drained into the lacrimal ducts, and a residue did not remain on the eye surface or eyelid. The subject reported no tear expulsion.
[0036] The subject reported that a hydrogel (soft) lens coated with trilinolein was easy to insert, and produced a noticeable amelioration of the normal discomfort associated when inserting a soft lens. Once inserted, the subject could not feel the presence of the coated lens. The ...
example 3
Tripalmitolein(1,2,3-tri(cis-9-hexadecenoyl)glycerol) (Sigma Chemicals, 98%).
[0037] The subject reported that a gas permeable (hard) lens coated with tripalmitolein was very comfortable to insert. In comparison to a hard lens coated with triolein, however, the sensation caused by the edges of the lens on the eye was not reduced to the same extent by a hard lens coated in tripalmitolein. Once inserted, the subject could not feel the presence of the coated lens. The subject's vision through the coated lens was excessively blurred. Excess tripalmitolein did not drain into the lacrimal ducts, and had to be physically removed.
[0038] The subject reported that a hydrogel (soft) lens coated with tripalmitolein was very difficult to insert as the lens was more adhesive to a finger coated with the fluid than to the actual ocular substrate. However, once the lens was inserted onto the eye, the subject found the soft lens coated with tripalmitolein to be comfortable. The subject's vision thr...
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Abstract
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