Ophthalmic fluid

a technology of ophthalmic fluid and ophthalmic lipids, which is applied in the field of ophthalmic fluid, can solve the problems of keratoconjunctivitis and contact lens intolerance, dry eye syndrome, and reduced body's ability to produce lubricating lipids

Inactive Publication Date: 2007-01-25
SLY ANTHONY WILLIAM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Meibomian gland dysfunction may result in dry eye syndrome, keratoconjunctivitis and contact lens intolerance, presumably due to an inadequate or a compromised tear film which is secondary to the meibomian gland dysfunction itself.
Meibomian gland dysfunction may be often induced by soft contact lens wear, whilst mebomianitis may result from hard contact lens wear.
Certain medications such as antidepressants, decongestants, diuretics, ulcer medication, tranquillisers and beta blockers can also decrease the body's ability to produce lubricating lipids.
Similarly, behavioural patterns, particularly the tendency for VDU users to ignore the normal blinking process, may also interrupt tear production.
Contact lens wearers appear to be particularly susceptible to evaporative dry eye syndrome.
Thus, the sheer mass of any contact lens may compromise the specific functions of the tear film which include the flushing action, the prevention of desiccation of the ocular tissue, the lubrication of the ocular and palpebral surfaces, the formation of an optically smooth curved surface, a vehicle for oxygen and carbon dioxide transport. and the defence of the cornea against trauma, infection or disease.
However, all contemporary contact lenses are unable to mimic the ocular surface properties, and therefore a comparable tear film on the lens surfaces is unable to form.
When the contact lens is placed on the eye, the lens alters the normal structure of the tear film and affects its rate of evaporation.
It is thought that the lipid layer is compromised causing dehydration of the aqueous layer to accelerate and tears to macerate the skin.

Method used

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  • Ophthalmic fluid
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Examples

Experimental program
Comparison scheme
Effect test

example 1

Triolein(1,2,3-tri(cis-9-octadecenoyl)glycerol) (Sigma Chemicals, 99%).

[0033] The subject reported that a gas permeable (hard) lens coated with triolein was very comfortable to insert, the edges of the lens seemingly smoothed out so as to reduce, but not totally eliminate, the normal discomfort associated when inserting a hard lens. Once inserted, the subject could not feel the presence of the coated lens. The subject's vision through the coated lens was excessively and persistently blurred. Excess triglyceride did not drain into the lacrimal ducts, and had to be physically removed.

[0034] The subject reported that a hydrogel (soft) lens coated with triolein was very difficult to insert, and did not noticeably ameliorate the normal discomfort associated when inserting a soft lens. The subject's vision through the coated lens was clear.

example 2

Trilinolein(1,2,3-tri(cis,cis-9,12-octadecadienoyl)glycerol) (Sigma Chemicals, 99%).

[0035] The subject reported that a gas permeable (hard) lens coated with trilinolein was very comfortable to insert. In comparison to a hard lens coated with triolein, however, the sensation caused by the edges of the lens on the eye was not reduced to the same extent by a hard lens coated in trilinolein. Once inserted, the subject could not feel the presence of the coated lens. The subject initially experienced blurred vision which cleared after approximately 60 seconds. Excess triglyceride drained into the lacrimal ducts, and a residue did not remain on the eye surface or eyelid. The subject reported no tear expulsion.

[0036] The subject reported that a hydrogel (soft) lens coated with trilinolein was easy to insert, and produced a noticeable amelioration of the normal discomfort associated when inserting a soft lens. Once inserted, the subject could not feel the presence of the coated lens. The ...

example 3

Tripalmitolein(1,2,3-tri(cis-9-hexadecenoyl)glycerol) (Sigma Chemicals, 98%).

[0037] The subject reported that a gas permeable (hard) lens coated with tripalmitolein was very comfortable to insert. In comparison to a hard lens coated with triolein, however, the sensation caused by the edges of the lens on the eye was not reduced to the same extent by a hard lens coated in tripalmitolein. Once inserted, the subject could not feel the presence of the coated lens. The subject's vision through the coated lens was excessively blurred. Excess tripalmitolein did not drain into the lacrimal ducts, and had to be physically removed.

[0038] The subject reported that a hydrogel (soft) lens coated with tripalmitolein was very difficult to insert as the lens was more adhesive to a finger coated with the fluid than to the actual ocular substrate. However, once the lens was inserted onto the eye, the subject found the soft lens coated with tripalmitolein to be comfortable. The subject's vision thr...

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Abstract

An ophthalmic fluid containing at least one triglyceride, diglyceride, or monoglyceride which is chemically similar or compatible with compounds found naturally in the lipid layer of the tear film of an ocular substrate. Preferably the glycerides are derived from a fatty acid containing at least one unsaturated bond in a cis-configuration in the fatty acid residue. The ophthalmic fluid is arranged in use to provide a protective film across a tear film of an ocular substrate. Furthermore, the ophthalmic fluid is also arranged in use to provide a protective film intermediate a lipid layer of the tear film of the ocular substrate and a contact lens.

Description

FIELD OF THE INVENTION [0001] The present invention relates to an ophthalmic fluid for improving wear comfort of contact lenses. BACKGROUND OF THE INVENTION [0002] The tear film, which is the interface between the external environment and the ocular surface, has several different functions. It forms a smooth refractive surface over the otherwise irregular corneal surface and lubricates the eyelids. Moreover, it maintains an optimal extracellular environment for epithelial cells of the cornea and conjunctiva where the electrolyte composition, osmolarity, pH, oxygen and carbon dioxide concentrations, nutrient and growth factor concentrations are regulated within narrow limits. [0003] Tears dilute and wash away noxious stimuli. They also provide an antibacterial system for the ocular surface and serve as an entry pathway for polymorphonuclear leukocytes in the case of injury to the ocular surface. As tears have many and varied functions, it is not surprising that they have a complex st...

Claims

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Application Information

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Patent Type & AuthorityApplications(United States)
IPC IPC(8): A61K31/22A61K9/00G02C13/00A61K31/231A61K31/232A61P27/02A61P27/04
CPCA61K9/0048A61K31/231A61K31/232Y10S514/915A61K47/44Y10S514/912A61K47/14A61P27/02A61P27/04A61K31/22
InventorSLY, ANTHONY WILLIAM
OwnerSLY ANTHONY WILLIAM