Sphingosine 1-phosphate receptor gene, SPPR

a sphingosine 1-phosphate receptor and gene technology, applied in the field of sphingosine 1-phosphate receptor gene, can solve the problems of uncomplete understanding of lgl, and achieve the effect of large-scale production of sphingosine 1-phosphate receptor protein
US20070105148A1Inactive Publication Date: 2007-05-10UNIV OF SOUTH FLORIDA
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
UNIV OF SOUTH FLORIDA
Publication Date
2007-05-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

A novel sphingosine 1-phosphate receptor gene, herein termed sppr, and its splice variants. Sppr is up-regulated in LGL and is useful, for example, in the diagnosis and treatment of certain lymphoproliferative, neurodegenerative and autoimmune diseases.
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Description

FIELD OF THE INVENTION

[0001] The present invention relates to the genetics of autoimmune diseases, including lymphoproliferative diseases, such as large granular lymphocyte leukemia (LGL), and rheumatoid arthritis (RA). Specifically, the invention relates to a novel sphingosine 1-phosphate receptor gene, herein termed sppr, and its splice variants. Sppr is up-regulated in LGL and is useful, for example, in the diagnosis and treatment of certain lymphoproliferative, neurodegenerative and autoimmune diseases. BACKGROUND OF THE INVENTION

[0002] Large granular lymphocyte leukemia (LGL) is a rare form of lymphoproliferative disorder often associated with autoimmune disease (Loughran T. P., Clonal diseases of large granular lymphocytes. Blood 82, 1-14, 1993).

[0003] The cause of LGL is still not fully understood. An increased count of large granular lymphocytes is characteristic of LGL leukemia. Patients with clonal CD3+LGL, as determined by cytogenetic or T-cell receptor (TCR) gene rear...

Claims

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