Methods of Producing Influenza Vaccine Compositions

a technology of compositions and influenza vaccines, applied in the field of methods of producing influenza vaccine compositions, can solve the problems of delayed and shortages in production and distribution, inability to produce influenza pathogenic strains according to established tissue culture methods, and inability to grow all pathogenic strains of influenza well in cell cultur

Inactive Publication Date: 2007-07-12
MEDLMMUNE VACCINES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented method allows for creation of viruses that can infect humans with different types of fluids like water-based liquors, foods containing bacteria, blood products, fats, oils, saliva, mucus, airborne particles, germ cells, tissues, plants, animals, yeast, spores, fungi, algae, amoeba chlorella, protozoan parasites, nematodes, worms, pollen grains, small arthropods, insect vectors, birds, fishes, seafoys, frogs, dogs, cows, horseshocks, primates, reptiles, bird's beaks, whales, seals, mothers, sheepflies, rodents, snakes, scorpions, mitochondria, lizards, muscles, joint paints, teeth, dental plaque, gums, sutures, staples, tools, guns, knives, snowpacks, rainbots, firearms, clothing items made up of these materials.

Problems solved by technology

The technical problem addressed in this patent is the need for improved methods of producing influenza viruses for vaccine production. The current methods of production in hen eggs have limitations in terms of flexibility and shortages in production and distribution, while methods in cell culture have not been successful with all strains of influenza. The present invention provides methods to increase the production of influenza viruses in both traditional and new methods, and also includes other benefits that will become apparent upon review of the patent.

Method used

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  • Methods of Producing Influenza Vaccine Compositions
  • Methods of Producing Influenza Vaccine Compositions
  • Methods of Producing Influenza Vaccine Compositions

Examples

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Embodiment Construction

[0069] The present invention includes methods and compositions to increase throughput and output of viruses and virus composition productions suitable for vaccine production / use. Included are methods and compositions for, e.g., selecting for desired reassortants in virus production, temperature conditioning / filtration, rocking, antibody selection, potency assays, and many additional features as described in more detail herein.

[0070] It will be appreciated by those skilled in the art that the various steps herein are not required to be all performed or exist in the same production series. Thus, while in some preferred embodiments, all steps and / or compositions herein are performed or exist, e.g., as outlined in Table 1, in other embodiments, one or more steps are optionally, e.g., omitted, changed (in scope, order, placement, etc.) or the like.

[0071] The basic overview of the methods and compositions for virus production herein are outlined in Table 1. Once again, as is to be empha...

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Abstract

Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.

Description

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Claims

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Application Information

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Owner MEDLMMUNE VACCINES
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