Methods of Producing Influenza Vaccine Compositions
a technology of compositions and influenza vaccines, applied in the field of methods of producing influenza vaccine compositions, can solve the problems of delayed and shortages in production and distribution, inability to produce influenza pathogenic strains according to established tissue culture methods, and inability to grow all pathogenic strains of influenza well in cell cultur
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[0069] The present invention includes methods and compositions to increase throughput and output of viruses and virus composition productions suitable for vaccine production / use. Included are methods and compositions for, e.g., selecting for desired reassortants in virus production, temperature conditioning / filtration, rocking, antibody selection, potency assays, and many additional features as described in more detail herein.
[0070] It will be appreciated by those skilled in the art that the various steps herein are not required to be all performed or exist in the same production series. Thus, while in some preferred embodiments, all steps and / or compositions herein are performed or exist, e.g., as outlined in Table 1, in other embodiments, one or more steps are optionally, e.g., omitted, changed (in scope, order, placement, etc.) or the like.
[0071] The basic overview of the methods and compositions for virus production herein are outlined in Table 1. Once again, as is to be empha...
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