Remedy for overactive bladder comprising acetic acid anilide derivative as the active ingredient
a technology of acetic acid anilide and active ingredient, which is applied in the direction of biocide, drug composition, animal repellent, etc., can solve the problems of not always achieving satisfactory clinical results, and achieve the effect of improving symptoms and reducing symptoms
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example 1
Isolated Rat Bladder Smooth Muscle Relaxation Test
Test Method
[0032]The test was conducted by referring to The Journal of Urology, 1999, volume 161, page 680.
[0033]Male rats of Wistar strain of 10 to 11 weeks age were sacrificed by depletion, whole bladder was isolated by laparotomy and bladder sections each being in a size of about 3×10 mm were prepared in a nutrient solution which was well oxygenated with 95% O2 and 5% CO2 (Krebs-Henseleit solution (118.4 mM NaCl, 4.7 mM KCl, 1.2 mM KH2PO4; 1.2 mM MgSO4, 2.5 mM CaCl2, 25.0 mM NaHCO3 and 11.1 mM glucose)). The section was hung in a Magnus tube in which a nutrient solution (Krebs-Henseleit solution) of 37° C. into which 95% O2 and 5% CO2 were aerated, stabilized for 30 to 60 minutes with a load of 1 g and 10−6 M carbachol (CCh) or 40 mM potassium chloride (KCl) was repeatedly applied thereto whereupon it was confirmed that reactivity to CCh or KCl became almost constant. After contraction by 10−6 M CCh or 40 mM KCl was induced and th...
example 2
Rat Rhythmic Bladder Contraction Measurement Test
Test Method
[0036]The test was conducted by referring to European Journal of Pharmacology, 2000, volume 407, page 175.
1. Measuring Method
[0037]Female rats (225 to 290 g) of Wistar strain was used for the test. Under anesthetization with urethane, right and left ureters were ligated and cut and, after that, a polyethylene cannula was inserted from external urinary meatus and fixed. One end of the fixed cannula was connected to a pressure transducer via a three-way cock and pressure in the bladder was measured. Another end thereof was connected to a syringe pump and a physiological saline solution was continuously infused at a constant rate into bladder whereupon rhythmic bladder contraction was induced. The continuous infusion of a physiological saline solution was stopped after a rhythmic bladder contraction was noted. After the rhythmic bladder contraction was stabilized, drug or vehicle was administered from a catheter for administra...
example 3
Test for Measurement of Urination Function of Model Rat Suffering from Overactive Bladder Induced by Cyclophosphamide
[0042]Overactive bladder model rats induced by cyclophosphamide were prepared by referring to British Journal of Pharmacology, 2000, volume 130, page 331 and the following test was conducted.
Test Method
1. Measuring Method
[0043]Female rats (220 to 230 g) of Wistar strain were used for the test. Under anesthetization with pentobarbital sodium, a catheter for infusion of physiological saline solution and for measurement of pressure in bladder was inserted into bladder from the top of the bladder and fixed while a catheter for administration of a drug was inserted into carotid vein and fixed. Cyclophosphamide (CYP) was administered into abdominal cavity and, after being recovered, the rats were returned to a feeding cage. On the next day of the operation, one end of the catheter inserted into bladder of the rat was connected to a syringe pump via a three-way cock and a ph...
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