Cyclosporine compositions for enhancing nail growth

a technology of cyclosporine and composition, which is applied in the direction of drug composition, pedicure, peptide/protein ingredients, etc., can solve the problems of lack of thickness and strength, lack of smoothness and tendency to tear, and poor nail growth, so as to stimulate increase the growth of nails and cuticles, and strengthen and smooth the nail and cuticle. , the effect of increasing the growth of nails

Inactive Publication Date: 2011-04-21
ALLERGAN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment of fingernail and toe nail problems due to various conditions such as anemia, vitamin or mineral deficiency, onycohrrhexis, kidney and liver disorders, psoriasis, vascular disease (e.g., Raynaud's disease) and heart disease often result in poor nail growth, vertical trenches, pitting, cracking, horizontal lines, lack of thickness and strength, lack of smoothness and tendency to tear remains a significant problem.
The problem with current treatments for improving nail health is that they are mainly cosmetic in nature, largely ineffective and time consuming.

Method used

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  • Cyclosporine compositions for enhancing nail growth
  • Cyclosporine compositions for enhancing nail growth

Examples

Experimental program
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Effect test

example 1

[0075]A female patient, age 51, with fingernails with pronounced horizontal ridges on her fingernails (“Beau's Lines”) and poor nail growth, topically applies four times a day with an applicator brush an emulsion of 0.05% cyclosporine A sold under the tradename RESTASIS® by Allergan, Inc. of Irvine, Calif. After 7 days of application, the subject's fingernails will experience accelerated growth without the presence of horizontal ridges.

example 2

[0076]A male patient, age 44, with fingernails experiencing vertical splitting and pitting possibly due to vitamin or mineral deficiency, topically applies ten times a day with an applicator an emulsion of 0.05% cyclosporine A sold under the tradename RESTASIS® by Allergan, Inc. of Irvine, Calif. After ten days of application, the subject's fingernails will experience accelerated growth and increased thickness and the disappearance of pits at the portion of the nail growing upward from the eponychium and lunula area of the finger without the presence of pits.

example 3

[0077]A female patient, age 45, with brittle (onycohrrhexis) and thinning nails with poor growth, topically applies twelve times a day with a squeezable applicator, an aqueous solution of 0.01% cyclosporine A. After ten days of application, the subject's fingernails will experience significant accelerated growth with thicker and less brittle nails emerging from the nail matrix.

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Abstract

The present invention is directed to cyclosporine compositions and methods for stimulating the growth of nails and cuticles in a mammal, including humans. The compositions may be administered topically to the nail bed, nail matrix and cuticle in an amount effective to increase nail growth and thicken, strengthen and smooth the nail. The composition is also effective in strengthening and growing nails, including fingernails and toenails.

Description

RELATED APPLICATION[0001]This application claims the benefit of U.S. Provisional Application Ser. No. 61 / 143,317, filed Jan. 8, 2010; U.S. Provisional Application Ser. No. 61 / 181,353, filed May 27, 2009; U.S. Provisional Application Ser. No. 61 / 160,946 filed Mar. 17, 2009; and U.S. Provisional Application Ser. No. 61 / 181,165 filed May 26, 2009, each of which is hereby incorporated by reference in its entirety.FIELD OF THE INVENTION[0002]The present application is directed to cyclosporine compositions for enhancing nail and cuticle growth.BACKGROUND OF THE INVENTION[0003]Nails, including toenails and fingernails, are primarily composed of the protein keratin. Fingernails and toenails are living tissue. The nail is formed in a pocket of skin which has grown inward and is called the nail matrix. This area generates the nail and is also called the root of the nail. The outer layer of the matrix contains specialized cells that create the keratin that grows out as the nail plate.[0004]The...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/13A61P43/00
CPCA61K8/64A61Q3/00A61K38/13A61P17/00A61P17/06A61P17/16A61P43/00A61K9/107A61Q3/02
Inventor MULLINS, DEBBIE D.STUCKER, CONNIE M.WHITCUP, SCOTT M.SCHIFFMAN, RHETT M.WALT, JOHN G.
Owner ALLERGAN INC
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