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Diagnostic methods

Inactive Publication Date: 2011-05-12
ISIS INNOVATION LTD
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Benefits of technology

[0063]SNPs tend to be evolutionarily stable from generation to generation and, as such, can be used to study specific genetic abnormalities throughout a population. If SNPs occur in the protein coding region it can lead to the expression of a variant, sometimes defective, form of the protein that may lead to development of a genetic disease. Such SNPs can therefore serve as effective indicators of the genetic disease. Some SNPs may occur in non-coding regions,

Problems solved by technology

Given their small size and multiple comparisons however, these small studies did not provide good a priori evidence for any genetic associations with statin-related myopathy.

Method used

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[0156]The SEARCH (Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine) trial among 12,064 participants with a history of myocardial infarction aimed to show whether allocation to 80 mg simvastatin daily for about 7 years safely produces greater reductions in cardiovascular risk than allocation to a standard 20 mg simvastatin daily regimen.17

[0157]During an average follow-up of about 6 years among the 6031 participants allocated 80 mg simvastatin daily in SEARCH, 49 definite cases of myopathy had occurred and a further 49 participants were identified as having incipient myopathy (see Methods). More than half of these 98 cases of definite or incipient myopathy arose during the first year of follow-up. The mechanisms by which statins cause myopathy remain unknown, but they appear to be related to statin concentrations in the blood. Interim safety analyses in SEARCH revealed a strong, but previously unrecognised, association between the use of amiodarone...

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Abstract

This invention relates to a method of determining the susceptibility of an individual to statin-induced myopathy, comprising detecting the presence or absence of one or more polymorphisms in the SLCO1B1 gene in a biological sample from an individual, whereby the presence of one or more polymorphisms indicates that the individual has altered susceptibility to statin-induced myopathy.

Description

TECHNICAL FIELD[0001]The present invention relates to diagnostic methods for detecting the susceptibility of an individual to statin-induced myopathy.BACKGROUND OF THE INVENTION[0002]The statins are a widely-used class of drugs that lower LDL (low density lipoprotein) cholesterol by inhibiting the enzyme 3-hydroxy-3-methylglutaryl-coenzyme-A (HMG-CoA) reductase and thereby reducing the production of cholesterol by the liver. Large-scale randomised evidence shows that statin therapy reduces the incidence of heart attacks, strokes and revascularisations by about one fifth per 1 mmol / L LDL-cholesterol reduction.1 The benefits achieved with statin use appear to relate primarily to an individual's absolute risk of such events, and to the absolute size of the LDL cholesterol reduction. The additional benefits seen with more intensive statin therapy have resulted in a trend towards the use of higher doses of statin.[0003]Rarely, statins can cause muscle pain or weakness with elevated blood...

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Application Information

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IPC IPC(8): C12Q1/68A61K31/366C07H21/00A61P9/00A61P25/00A61P3/06A61P21/00
CPCC12Q1/6883C12Q2600/156C12Q1/6876C12Q2600/172C12Q2600/106A61P21/00A61P25/00A61P3/06A61P9/00
Inventor LINK, EMMAPARISH, SARAHCOLLINS, RORYLATHROP, MARK
Owner ISIS INNOVATION LTD
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