Method of producing a nicotine medicament and a medicament made by the method
a nicotine and method technology, applied in the field of nicotine medicaments, can solve the problems that current tobacco replacement therapies have not been effective in satisfying a person's craving for cigarettes, and achieve the effects of reducing aggregation of particles, avoiding irritation, and facilitating aerosolization of particles
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[0068]3 g of nicotine and 27 g of lactose were added to 200 g of water. The mixture was stirred until the solution was clear (approximately 10 minutes). The mixture was spray dried in a Buchi Mini Spray Dryer 190, with an air flow rate of 500 ml / minute, an inlet temperature of 165° C. and an outlet temperature of 87° C. The nicotine and lactose solution was fed into the atomizer at a rate of 7 ml / min. The results are set out in Table 1.
[0069]This experimental procedure was repeated under each of the sets of conditions set out in Table 1. Determination of the nicotine content in the nicotine lactose composite product was determined by using UV spectrophotometry at a wavelength of 262 nm. Particle size was determined using laser diffraction methods known in the art.
[0070]A concentration of 3% (w / v) of nicotine in solution, with a 4:6 ratio of nicotine to lactose (w / w) produced the highest concentration in the finished product. An air flow higher than 750 ml / min. resulted in a wet powd...
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