Method of diagnosing bladder cancer

a bladder cancer and cancer technology, applied in the field of bladder cancer diagnosis, can solve the problems of affecting the treatment effect, and affecting the treatment effect, and achieve the effect of improving the treatment effect, and improving the treatment
US20120101023A1Inactive Publication Date: 2012-04-26ERASMUS UNIV MEDICAL CENT ROTTERDAM ERASMUS MC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ERASMUS UNIV MEDICAL CENT ROTTERDAM ERASMUS MC
Publication Date
2012-04-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a method of diagnosing cancer in a subject comprising detecting in the DNA of said subject at least one hypermethylated CpG island associated with said cancer, wherein an elevation in the level of methylation in said CpG island of said subject, relative to the level of methylation in said CpG island of a control subject, is indicative of said CpG island being hypermethylated.
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Description

FIELD OF THE INVENTION

[0001] The present invention is in the field of bladder cancer diagnosis, and in particular the methods for predicting the progression of bladder cancer tumors. The invention provides diagnostic methods and diagnostic compositions for use in such methods. The invention further provides therapeutic targets for treating specific forms of bladder cancers.BACKGROUND OF THE INVENTION

[0002] Bladder cancer is the fifth most common cancer in the western world with an incidence of 20 new cases per year per 100,000 people in the U.S. Unfortunately, these statistics do not include superficial pTa bladder cancer, which represents the most common type of bladder cancer. In the Netherlands, the incidence of both superficial and invasive bladder cancer is estimated as about 30 new cases per year per 100,000 people. This is in accordance with data from global cancer statistics for the western world. Superficial bladder tumors are removed by transurethral resection. However, up t...

Claims

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