Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

DNA methylation diagnostic test for breast cancer

a technology of methylation and breast cancer, applied in the direction of anti-cancer agents, biochemistry apparatus and processes, drug compositions, etc., can solve the problems of overtreatment of a significant number of patients, no tool to predict concurrent or subsequent invasion of dcis,

Pending Publication Date: 2022-11-03
CITY OF HOPE
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no tool to predict concurrent or subsequent invasion in DCIS.
This results in overtreatment of a significant number of patients who carry the stigma of cancer.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • DNA methylation diagnostic test for breast cancer
  • DNA methylation diagnostic test for breast cancer
  • DNA methylation diagnostic test for breast cancer

Examples

Experimental program
Comparison scheme
Effect test

example 1

nt of an Epigenetic Biomarker Panel for DCIS Invasiveness

[0218]DNA methylation patterns were evaluated in 7 DCIS samples from patients without reported invasion (pure DCIS), and 3 DCIS samples from patients with IDC. In order to identify DNA methylation changes exclusive to cancer cells, malignant cells located within the involved ducts of DICS were isolated by laser capture microdissection (FIG. 1A). Genome-wide profiling of DNA methylation was performed. Reduced representation bisulfite sequencing (RRBS) was used to evaluate DNA methylation patterns at gene promoters in captured cells (FIG. 1C). Clustering analysis clearly separated DCIS samples into two epigenetic groups. The first DCIS epigenetic group was associated with almost no DNA methylation at promoters and obtained from patients lacking invasion (pure DCIS). At the same time, specimens from the second epigenetic group of DCIS were characterized by extensive accumulation of DNA methylation at promoters. This group contain...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
lengthaaaaaaaaaa
deoxyribonucleic acidaaaaaaaaaa
thermostableaaaaaaaaaa
Login to View More

Abstract

The present subject matter provides, inter alia, a method of diagnosing invasive ductal cancer or detecting invasive ductal cancer risk in a subject who has ductal carcinoma in situ, a method of treating breast cancer in a subject detected to have invasive ductal cancer or determined to be at risk of invasive ductal cancer, compositions for detecting invasive presence or potential in ductal carcinoma in situ in a subject, and kits including reagents and composition for detecting invasive presence or potential in ductal carcinoma in situ in a subject.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of priority to U.S. Provisional Application No. 62 / 611,910, filed Dec. 29, 2017, which is hereby incorporated by reference in its entirety for all purposes.BACKGROUND OF THE INVENTION[0002]Invasive breast cancer represents a quarter of all cancers diagnosed worldwide and its rate increases by 0.3% every year. Ductal carcinoma in situ (DCIS) is considered to be a pre-invasive form of breast cancer. Almost a quarter of all new breast cancers diagnosed in the United States are DCIS. However, patients with DCIS are treated with surgery and radiation, identically to patients presenting with invasive disease. Not all women with untreated DCIS will develop invasive ductal cancer (IDC). At present, there is no tool to predict concurrent or subsequent invasion in DCIS. This results in overtreatment of a significant number of patients who carry the stigma of cancer.BRIEF SUMMARY OF THE INVENTION[0003]The present ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/154A61P35/00
Inventor HAHN, MARIA A.YIM, JOHN H.FONG, YUMANLI, ARTHUR X.WU, XIWEITONG, SUN-WING T.R.
Owner CITY OF HOPE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com