The invention discloses a
vardenafil oral
soluble film which is prepared by the following steps: S1, slowly adding
methanesulfonic acid phenol into an organic solution at the temperature of-0.5 DEG C to 10 DEG C, and carrying out primary slow stirring and mixing on the solution, S2, adding required raw materials, carrying out mixing work, then waiting for the solution to naturally rise to
room temperature, and then waiting for the solution to react for 3-6 hours, so as to obtain the
vardenafil oral
soluble film. The invention discloses a preparation method of
vardenafil, which comprises the following steps of: adding an alkaline stabilizer and a corrigent into vardenafil, adding ice
salt water, slowly dropwise adding N-hydroxyethylpiperazine, slowly stirring and mixing, and waiting for reaction, and compared with the prior art, the preparation method has the beneficial effects that the alkaline stabilizer and the corrigent are added in the traditional vardenafil medicament production work, so that the preparation process is simple and convenient, and the cost is low. According to the present invention, the
bitter taste and the
odor produced during the taking of the vardenafil can be covered, such that the discomfort phenomenon during the taking of the user can be reduced so as to ensure the subsequent sales volume put into the market, and provide the guarantee for the subsequent
drug promotion work.