Method for extracting penicillin by magnetic ion liquid and reactor thereof

A magnetic ionic liquid and ionic liquid technology, applied in organic chemistry and other fields, can solve the problems of organic solvent loss, environmental pollution, explosion hazard, etc., and achieve the effects of preventing emulsification, low shear force, and enhanced mass transfer

Inactive Publication Date: 2009-02-11
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Claims
  • Application Information

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Problems solved by technology

There are three major disadvantages in this extraction process: it is necessary to add acid to adjust the pH value to denature the protein and cause emulsification of the system; the volatilization of the organic solvent causes environmental pollution, and there is a potential explosion hazard; the loss of the organic solvent and the low yield due to the entrainment of the two phases

Method used

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  • Method for extracting penicillin by magnetic ion liquid and reactor thereof
  • Method for extracting penicillin by magnetic ion liquid and reactor thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Embodiment 1: magnetic ionic liquid [bmim]FeCl 4 The result of extracting penicillin (using a three-blade propeller to stir)

[0040] 15ml of penicillin solution with a penicillin content of 1g / 100ml and 10ml of magnetic ionic liquid [bmim]FeCl 4 mix. Stir with a propeller at a speed of 300 rpm. Slight emulsification phenomenon after 10 minutes, centrifuged for 5 minutes, the extraction system was layered, and the upper aqueous phase and the lower ionic liquid phase were taken respectively. The aqueous phase solution was analyzed by polarimeter for penicillin content, and the ionic liquid phase was analyzed for penicillin content by high-performance liquid chromatography. The extraction rate of penicillin by ionic liquid was 76.65%.

Embodiment 2

[0041] Embodiment 2: magnetic ionic liquid [bmim]FeCl 4 The implementation results of extracting penicillin (using a reactor with rotating and lifting magnetic stirring isolation tank)

[0042] See eg figure 1 . An isolation tank 6 is installed in the reactor, and a rotary motor 4 is connected with a shaft 5 in the isolation tank 6. The bearing at one end of the rotary motor 4 is connected with the NdFeB permanent magnet 3, and the upper outer shell of the isolation tank 6 is connected with a sliding shaft. .

[0043] 15ml of penicillin solution with a penicillin content of 1g / 100ml and 10ml of magnetic ionic liquid [bmim]FeCl 4 mix. Such as figure 2 As shown in a, the magnetic ionic liquid and the penicillin solution in the reactor are in a layered state after mixing, the ionic liquid is in the lower layer 1, and the penicillin solution is in the upper layer 2; the upper part is a rotating and lifting magnetic stirring isolation tank; as figure 2 As shown in b, open th...

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Abstract

This invention relates to a method of using acidic, magnetic and hydrophobic ion liquid to extract penicillin, and reactor of magnetism whiping disperse system. Massfraction of penicillin in the mixture is 0.5 to 8%. The magnetic and hydrophobic ion liquid submit acidity, and massfraction of the ion liquid is 20 to 60%. The invention adopts [bmim] FeCl4 to extract penicillin, can reach 75% upwards extraction rate without acidification. The invention adopts reactor with gyrating, fluctuating magnetic stirring isolation pot, through outfield strengthening effect to realize intensive mixing and sharp separation of magnetic ion liquid and penicillin water solution; the magnetism of ion liquid realize low shearing whipping, and prevent emulsification in extraction process; the invention has no centrifugalization system after whipping, avoid biphase entrainment of traditional method; the power of this reactor is greatly less than conventional dasher, depress energy expenditure in extraction process.

Description

technical field [0001] The invention relates to a method and a reactor for extracting penicillin with a magnetic ionic liquid, in particular to a method for extracting penicillin with an acidic and magnetically functional hydrophobic ionic liquid, and a reactor for a magnetically stirred dispersion system. technical background [0002] Penicillin is one of the most common antibiotics. Its production process is to extract penicillin from the penicillin filtrate with an organic extraction solvent after the solid-liquid separation of the penicillin fermentation liquid, and then obtain the penicillin product through steps such as back extraction, crystallization and drying. The link of penicillin extraction is to use butyl acetate as the extractant, adding acid to adjust the pH value. This extraction process has three major disadvantages: it is necessary to add acid to adjust the pH value to denature the protein and cause emulsification of the system; the volatilization of the o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D499/18
Inventor 江洋洋郭晨余江刘会洲安震涛
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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