Fluorescent magnetic resonance bimodal imaging nano sensing material as well as preparation method and application thereof
A dual-mode imaging and sensing material technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of poor sensitivity, spatial resolution and poor tissue penetration, achieve short relaxation time, improve biological Compatibility, effect of reducing cytotoxicity
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Embodiment 1
[0029] 1ml 0.01mol / L TbCl 3 Ethanol solution and 1ml of 0.01mol / L GdCl 3 The ethanol solution was stirred and mixed, and 2ml of 0.03mol / L acac ethanol solution was added, and a magnetic stirrer was used at a rotating speed of 850rpm to stir at room temperature for 0.5 hours. Use dilute ammonia to adjust pH to 7, and then add 2ml of 0.01mol / L phen ethanol solution, The mixture was stirred at room temperature for 1.5 hours to obtain a rare earth gadolinium terbium binuclear complex solution.
[0030] Take 2ml of 10mg / ml sodium hyaluronate solution (prepared by 0.1mol / L, pH=5 acetic acid-sodium acetate buffer solution as solvent), add it to the rare earth gadolinium terbium binuclear complex solution obtained above, Stir at room temperature for 2 hours, then take 4 ml of 10 mg / ml chitosan solution (prepared from 0.1 mol / L, pH=5 acetic acid-sodium acetate buffer solution as solvent), add it to the solution, and stir at room temperature for 2.5 hours , obtain rare earth gadoliniu...
Embodiment 2
[0034] 1ml 0.01mol / L TbCl 3 Ethanol solution and 1ml of 0.01mol / L GdCl 3 The ethanol solution was stirred and mixed, and 2ml of 0.03mol / L acac ethanol solution was added, and a magnetic stirrer was used at a rotating speed of 850rpm to stir at room temperature for 0.5 hours. Use dilute ammonia to adjust pH to 7, and then add 2ml of 0.01mol / L phen ethanol solution, The mixture was stirred at room temperature for 1.5 hours to obtain a rare earth gadolinium terbium binuclear complex solution.
[0035] 1ml 0.01mol / L TbCl 3 Ethanol solution, add 1ml of 0.03mol / L acac ethanol solution, use a magnetic stirrer at a rotating speed of 850rpm, stir at room temperature for 0.5 hours, use dilute ammonia to adjust pH to 7, then add 1ml of 0.01mol / L phen ethanol solution, stir at room temperature After 1.5 hours, 3 ml of ethanol was added for dilution to obtain a rare earth terbium complex solution.
[0036] The fluorescence test was carried out on the rare earth gadolinium terbium binucl...
Embodiment 3
[0038] 1ml 0.01mol / L TbCl 3 Distilled aqueous solution and 1ml of 0.01mol / L GdCl 3 The distilled aqueous solution was stirred and mixed, the tta distilled aqueous solution of 2ml 0.03mol / L was added, and a magnetic stirrer was used under rotating speed 850rpm, and normal temperature was stirred for 0.5 hour, and the dilute ammonia water was used to adjust pH to 7, and then the phen distilled water solution of 2ml 0.01mol / L was added, The mixture was stirred at room temperature for 1.5 hours to obtain a rare earth gadolinium terbium binuclear complex solution.
[0039]Take 2ml of 10mg / ml sodium hyaluronate solution (prepared by 0.1mol / L, pH=5 acetic acid-sodium acetate buffer solution as solvent), add it to the rare earth gadolinium terbium binuclear complex solution obtained above, Stir at room temperature for 2 hours, then take 4 ml of 10 mg / ml chitosan solution (prepared from 0.1 mol / L, pH=5 acetic acid-sodium acetate buffer solution as solvent), add it to the solution, and...
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