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Pharmaceutical composition for treating heart failure

A technology of heart failure and composition, applied in the field of pharmaceutical composition for the treatment of heart failure, to achieve the effect of improving heart failure, reducing diastolic blood pressure, and scientific composition

Active Publication Date: 2009-09-02
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From ancient times to the present, many TCM physicians have conducted a large number of objective studies on TCM syndrome differentiation on heart failure, and believe that TCM has definite curative effects in treating congestive heart failure, especially in improving symptoms and improving the quality of life. There are relatively few new Chinese medicine preparations for the treatment of heart failure

Method used

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  • Pharmaceutical composition for treating heart failure
  • Pharmaceutical composition for treating heart failure
  • Pharmaceutical composition for treating heart failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Recipe: 6 parts of red ginseng, 30 parts of roasted Astragalus, 15 parts of Paofuzi, 9 parts of roasted Epimedium, 20 parts of Salvia, 9 parts of Chuanxiong, 9 parts of Citrus aurantium, 15 parts of Ophiopogon japonicus, 9 parts of Tinglizi.

[0027] 2. Production process:

[0028] 1. Extraction process of volatile oil: Citrus aurantium and Rhizoma Chuanxiong in the prescription are commonly used traditional Chinese medicines, which contain volatile oil components. In order to ensure the complete extraction of components, the extraction process is designed in the process. The specific extraction method is: crush Citrus aurantium and Chuanxiong into coarse powder, pass through a 40-mesh sieve, weigh the coarse powder of Citrus aurantium and Ligusticum chuanxiong according to the prescription, add 8 times the amount of water, soak for 3 hours, and extract by steam distillation for 12 hours , to get the volatile oil.

[0029] 2. Extraction process of medicinal material...

Embodiment 2

[0032] 1. Formula: 12 parts of red ginseng, 30 parts of roasted astragalus, 9 parts of paofuzi, 9 parts of roasted epimedium, 20 parts of salvia miltiorrhiza, 9 parts of Chuanxiong, 9 parts of Citrus aurantium, 12 parts of Radix Ophiopogon japonicus, 9 parts of Tinglizi.

[0033] 2. Production process:

[0034] With embodiment 1.

Embodiment 3

[0036] 1. Recipe: 8 parts of red ginseng, 30 parts of Sun-roasted Astragalus membranaceus, 12 parts of Paofuzi, 12 parts of Sun-roasted Epimedium, 15 parts of Salvia, 9 parts of Chuanxiong, 9 parts of Citrus aurantium, 9 parts of Ophiopogon japonicus, 9 parts of Tinglizi .

[0037] 2. Production process:

[0038] With embodiment 1.

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Abstract

The invention discloses a pharmaceutical composition for treating heart failure, which is prepared from the following medicines in parts by weight: 5-12 parts of red ginseng, 15-45 parts of sun-burned astragalus, 5-15 parts of paofuzi, and 8 parts of sun-baked epimedium -15 parts, 10-20 parts of Salvia miltiorrhiza, 5-15 parts of Chuanxiong, 5-15 parts of Citrus aurantii, 6-15 parts of Ophiopogon japonicus, 5-15 parts of Tinglizi, belonging to the field of traditional Chinese medicine. The invention has scientific formula, clear, reliable and stable extraction process. Acute toxicity and long-term toxicity tests show that the toxicity of this product is low, and pharmacodynamic tests show that the present invention has obvious improvement effect on canine experimental heart failure caused by sodium pentobarbital. The invention has obvious diuretic effect, can increase the urine output of rats, and can promote the excretion of K+, Na+ and Cl- in urine. At the same time, it also has the effect of resistance to hypoxia. Therefore, the invention has the pharmacological effect of obviously improving heart failure, can adjust and improve the function of cardiovascular system, and has low toxicity, which provides an experimental basis for clinical treatment of heart failure.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating heart failure, which belongs to the field of traditional Chinese medicine. Background technique [0002] Heart failure refers to a complex clinical syndrome caused by myocardial injury caused by any reason, which changes the structure and function of the myocardium, resulting in a decrease in ventricular pumping function. It is the terminal stage of various heart diseases. With the acceleration of the aging process of the population and the increase in the incidence of common cardiovascular diseases such as hypertension and coronary heart disease, the prevalence of heart failure is gradually increasing. According to foreign statistics, the prevalence of heart failure in the population is about 1.5% to 2.0%, while that of people over 65 years old can reach 6% to 10%. At present, there are about 5 million heart failure patients in the United States, about 400,000 newly diagnosed cases ea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61K36/75A61K36/714A61K36/53A61K36/481A61K36/31A61K36/296A61K36/258A61K36/236A61K9/00A61P9/04
Inventor 王士雯朱庆磊曹雪滨余颂涛金道山马路
Owner GENERAL HOSPITAL OF PLA
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