Water fennel total phenolic acid preparing process, and medicinal preparation using same as active component and use

A technology of total phenolic acid and cress, which is applied in the directions of medical preparations containing active ingredients, drug delivery, drug combination, etc., can solve the problems of low total phenolic acid yield, large loss of active ingredients and high cost

Active Publication Date: 2009-10-14
黄正明 +2
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  • Application Information

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Problems solved by technology

[0002] Commonly used extraction and separation processes are; alcohol extraction-water precipitation-ethyl acetate extraction method or acid-base method to obtain total phenolic acids. These methods either cause a large loss of active ingredients or destroy the components, resulting in low yields of total phenolic acids and high costs.

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  • Water fennel total phenolic acid preparing process, and medicinal preparation using same as active component and use

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Embodiment Construction

[0020] The following experimental examples are used to further illustrate the present invention, but do not limit the present invention in any way.

[0021] Grind the dried whole cress into a coarse powder, use 10-30 times the amount of hydrophilic solvent to extract by heating under reflux or cold soaking and percolation, heat extraction 2-3 times, each time for 1-3 hours, and then extract The solution is concentrated under reduced pressure below 60°C to an extract with a specific gravity of 1.15-1.30 (70°C); adding hot water 4-6 times the amount of the original drug, dissolving in stages, standing for 24 hours, and filtering, the filtrate polyamide is Carrier column chromatography, washing with water and eluting with a mixed solvent with a water:alcohol ratio of 50:50-5:95, collecting the water-pure liquid, concentrating under reduced pressure at a temperature lower than 60°C, and drying in vacuo to obtain Cress total phenolic acid extract.

[0022] The pharmaceutical prepa...

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Abstract

The invention discloses total phenolic acid of cress and its active ingredients hyperin, isoquercitrin, liaoxanthin, chlorogenic acid and the like. The invention also discloses a preparation method of cress total phenolic acid, which comprises the following steps: take cress medicinal material, add ethanol to extract, recover ethanol, obtain alcoholic extract, dissolve with boiling water, filter, put the supernatant on a polyamide column, and first Elute with water, then elute with ethanol, collect the eluent, recover ethanol, dry the extract in vacuum, measure the total phenolic acid content by colorimetry, and use the dry extract as the medicinal effective part, the total phenolic acid content Reaching more than 50%, reaching the national standard of 5 kinds of traditional Chinese medicine raw materials. In addition, the present invention also discloses the anti-cardiovascular (lowering blood pressure, anti-arrhythmia) diseases, cerebral ischemia and diabetes effects of total phenolic acid of cress as a raw material drug and a pharmaceutical composition with the active ingredient.

Description

technical field [0001] The invention belongs to the technical field of separation and purification of effective parts of plant medicines, can make the total phenolic acid content of the effective parts of watercress greater than 50%, and reach the national standard of five types of traditional Chinese medicine raw materials; use. Background technique [0002] Commonly used extraction and separation processes are; alcohol extraction-water precipitation-ethyl acetate extraction method or acid-base method to obtain total phenolic acids. These methods either cause a large loss of active ingredients or destroy the components, resulting in low yields of total phenolic acids and high costs. Therefore, it is necessary to study a new simple and efficient extraction and separation method, which is suitable for industrial production. Contents of the invention [0003] The purpose of the present invention is to disclose the method for preparing the total phenolic acid of cress; anoth...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/23A61K9/00A61P9/06A61P9/12A61P9/10A61P3/10
Inventor 黄正明杨新波曹文斌陈红艳杨坤
Owner 黄正明
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