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Combination of Chinese traditional medicine for treating insomnia

A technology for drugs and crude drugs, applied in the field of medicine, can solve problems such as difficulty in controlling drug quality, intellectual side effects, and troublesome taking, and achieve the effects of overcoming large toxic side effects, low drug toxic side effects, and definite curative effects

Active Publication Date: 2009-10-28
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the Chinese patent medicines for treating insomnia have many medicinal flavors, it is difficult to control the quality of the medicines, and they are not suitable for industrialized large-scale production; At the same time, it will cause damage to the body; in addition, the dosage forms of these drugs are mostly tablets, pills, oral liquids, etc., and the drug has a slow onset of action and is troublesome to take.
And at present all western medicines all have the following problems: 1, almost all sleeping pills, long-term continuous use all can produce tolerance and dependence
3. Other central inhibitory drugs, such as antihistamines, analgesics and ethanol, etc., when used in combination with this class of drugs, can enhance the inhibitory effect on the central nervous system, especially when used together with ethanol, they have a synergistic inhibitory effect on the central nervous system. can have serious consequences
4. Barbiturates and dichloral antipyrine cannot be used in patients with acute intermittent porphyria
5. Children should not use sleeping pills, which have side effects on intelligence; for elderly patients, they should be used with caution, because confusion may occur after taking the medicine

Method used

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  • Combination of Chinese traditional medicine for treating insomnia
  • Combination of Chinese traditional medicine for treating insomnia
  • Combination of Chinese traditional medicine for treating insomnia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] (a): Take 1380g of Suanzaoren, 828g of Albizia Julibrissin, 20.7g of Notoginseng, and 414g of Radix Glycyrrhizae;

[0143] (b): Take Suanzaoren coarse powder (through a 20-mesh sieve), Albizia Julibrissin, Radix Glycyrrhizae, add 10 times the amount of crude drug water, reflux for extraction for 2 hours, filter, and the filtrate for later use, add 10 times the amount of crude drug water to the dregs, and reflux extract for 2 hours. hour, filter, and the filtrate is set aside, add 10 times the amount of crude drug water to the dregs, reflux extraction for 2 hours, filter, combine the extracts for 3 times, concentrate under reduced pressure below 70°C to 1g crude drug / ml (D 60 =1.06~1.09), add 95% ethanol to make alcohol content reach 60%, leave standstill overnight, filter, and filtrate reclaims ethanol to 3g crude drug / ml (D 60 =1.12~1.14), add 95% ethanol to make the alcohol content reach 80%, let stand overnight, filter, and the filtrate is concentrated under reduced ...

Embodiment 2

[0146] (a): Take 690g of Suanzaoren, 500g of Albizia Julibrissin, 12.5g of Notoginseng, and 220g of Glycyrrhizae for later use;

[0147] (b): Take Suanzaoren coarse powder (through a 20-mesh sieve), Albizia Julibrissin, Radix Glycyrrhizae, add 12 times the crude drug amount of water, reflux for extraction for 3 hours, filter, and the filtrate for later use, add 10 times the crude drug amount of water to the dregs, and reflux extract 2 hour, filter, and the filtrate is set aside, then add 8 times the amount of crude drug water to the dregs, reflux extraction for 1 hour, filter, combine 3 extracts, concentrate under reduced pressure below 70 degrees Celsius to 1g crude drug / ml (D 60 =1.06~1.09), add 95% ethanol to make alcohol content reach 60%, leave standstill overnight, filter, and filtrate reclaims ethanol to 3g crude drug / ml (D 60 =1.12~1.14), add 95% ethanol to make the alcohol content reach 80%, let stand overnight, filter, and the filtrate is concentrated under reduced p...

Embodiment 3

[0149] (a) Get 2070g of Suanzaoren, 1200g of Albizia Julibrissin, 15g of Notoginseng, and 500g of Radix Glycyrrhizae for subsequent use;

[0150] (b) Take Suanzaoren coarse powder, Albizia julibrissin, and licorice, add 14 times the crude drug amount of water, reflux extraction for 5 hours, filter, and the filtrate is set aside, add 12 times the crude drug amount of water to the medicinal residues, reflux extract for 3 hours, filter, and the filtrate is set aside , adding 10 times the amount of crude drug water to the dregs, reflux extraction for 2 hours, filtering, and combining the extracts for 3 times, below 80°C, D 60 =1.06~1.09 Concentrate under reduced pressure to 1g crude drug / ml, add 99% ethanol to make the alcohol content reach 70%, let it stand overnight, filter, the filtrate reclaims ethanol, in D 60 =Concentrate to 3g crude drug / ml at 1.12~1.14, add 90~99% ethanol to make the alcohol content reach 75~85%, let it stand overnight, filter, and concentrate the filtrate...

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Abstract

The invention provides a medicine for treating insomnia prepared from raw materials such as jujube seed, albizia julibrissin, notoginseng saponin, licorice and the like. The medicine of the present invention can not only be used to treat various types of insomnia, such as stress-type insomnia, bad habit-type insomnia, anxiety-type insomnia, depression-type insomnia, in addition, the medicine can also be used to treat mental diseases, such as depression, neurosis, psychosis, etc. Schizophrenia, Alzheimer's disease, anxiety disorder, obsessive-compulsive disorder, borderline personality disorder and other diseases.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation for treating insomnia made from traditional Chinese medicines. Background technique [0002] With the rapid development of China's social economy, the acceleration of urbanization and population aging, and the influence of factors such as competitive pressure, unemployment, and changes in the pace of life, the harm of mental disorders to the health of the Chinese people is "increasingly prominent and serious." Cause insomnia, depression, neurosis, schizophrenia and other mental diseases to rise sharply. Due to the increasing incidence of the disease, it is called "the killer of the new century". People pay more and more attention to mental illness, because mental illness not only endangers the patient's own health and life, but also endangers family members and social security, causing huge economic losses and adverse social impact. Mental illness includes many kinds such a...

Claims

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Application Information

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IPC IPC(8): A61K36/725A61K36/484A61K36/48A61K36/258A61K9/20A61P25/20A61P25/00
Inventor 叶正良张伯礼鄂秀辉周桂荣李伟
Owner TIANJIN TASLY PHARMA CO LTD
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