Carrier bacterin of attenuated typhoid bacterium of carrying tubercle branch bacillus Ag85B
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- WUHAN UNIV
- Publication Date
- 2007-10-10
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention belongs to the fields of molecular microbiology, molecular immunity and infection immunity. In particular, molecular cloning is used to design and prepare an attenuated Salmonella typhi vector vaccine carrying Mycobacterium tuberculosis Ag85B. Background technique
[0002] Tuberculosis (Tuberculosis, TB) is an infectious disease that seriously endangers human health, caused by Mycobacterium tuberculosis (Mycobacterium tuberculosis, MTB) infection. According to WHO estimates, 1 / 3 of the global population has been infected with Mycobacterium tuberculosis, with 8-10 million new cases each year, of which about 3 million deaths, the number of deaths from tuberculosis is the sum of the deaths from other infectious diseases [1] . China is the second hardest-hit area of tuberculosis in the world except India. At present, the number of tuberculosis cases in my country has increased by more than one million every year, and the annual death toll...