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Method for preparing extraction of acanthopanax senticousus saponins

A technology of Acanthopanax senticosus and extract, which is applied in the field of preparation of Acanthopanax senticosus saponin extract, can solve the problems of low extraction and separation efficiency, low purity of effective parts or components, etc., and achieve high extraction and separation efficiency, high content, high physiological active effect

Inactive Publication Date: 2007-12-12
TIANJIN TASLY ZHIJIAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional process has low extraction and separation efficiency, and the purity of the effective parts or components is not high. Therefore, it is of great significance to study the extraction and separation methods of more effective and high-purity eleutherosides

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Get Acanthopanax medicinal materials (roots, rhizomes, stems), pulverize, add water and boil to extract three times and control the pH, the first time is 6 times of the amount of medicinal materials and 0.7% Na2CO3 of the amount of medicinal materials, and the second time is 4 times of the amount of medicinal materials The amount of water and 0.3% Na2CO3 of the medicinal material, the third time is 4 times the water of the medicinal material; side countercurrent circulation extraction, after boiling, keep for 1.5, 1, 1 hour respectively; the medicinal liquid is combined and cooled to room temperature, filtered, and the filtrate has been processed The macroporous type weakly basic anion D392 exchange column (Nankai University Chemical Plant), rinses with 2% NaOH solution of 2 times of resin bed volume, and discards the rinse solution; then rinses with pure water 3 times, discards the water rinse solution; The 70% ethanol of 7 times resin bed volume is eluted, collects elu...

Embodiment 2

[0017] Take the leaves of Acanthopanax senticosus, crush them, add water and ultrasonically extract four times and control the pH, the first time is 5 times the amount of water and 0.9% NaHCO3 of the amount of medicinal materials, and the second time is 4 times the amount of water and 0.5% of medicinal materials amount of NaHCO3, the third and fourth times are 3 times the amount of water of the amount of medicinal material; the medicinal solution is combined and cooled to room temperature, filtered, and the treated macroporous type weakly basic anion D380 exchange column (Nankai University Chemical Industry Co., Ltd. factory), rinse with 2.5% NaOH solution 1.5 times the volume of the resin bed, and discard the rinse solution; then rinse with 4 times pure water, discard the water rinse solution; elute with 65% ethanol that is 8 times the volume of the resin bed, and collect the elution liquid, concentrated to a thick paste (relative density at 50° C. is 1.28 to 1.33), and dried ...

Embodiment 3

[0019] Get Acanthopanax medicinal materials (roots, rhizomes, stems), pulverize, add 50% ethanol to reflux and extract three times and control the pH, the first time is 5 times the Na2CO3 of 50% ethanol amount and 1% medicinal material amount, and the second time 4 times the amount of 50% ethanol and 0.5% Na2CO3 of the amount of medicinal materials, the third time is 4 times the amount of 50% ethanol of the amount of medicinal materials; side countercurrent circulation reflux extraction, after the reflux starts, keep it for 1.5, 1, and 1 hour respectively; Filter the medicinal liquid and combine the filtrates, concentrate the filtrate under reduced pressure at 70°C until there is no alcohol smell, dilute the concentrated liquid with water until the ratio of medicinal materials to liquid is 1:1.5, filter, and the treated macroporous strong basic anion D201 on the filtrate Exchange column (Nankai University Chemical Plant), rinse with 2% NaOH solution of 2 times the volume of the...

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Abstract

The invention discloses a process for preparing acanthopanax root saponin extract comprising the following steps in sequence, charging dissolvent into acanthopanax root, rhizome, stem or leaf, adjusting the solution to alkalinity, carrying out extraction, obtaining extract, passing the extract through macroscopic alkaline anion exchange resin, flushing with alkaline water and pure water, discarding the flushing fluid, eluting with water-containing ethanol, and concentrating the eluent.

Description

technical field [0001] The invention belongs to a preparation method of a traditional Chinese medicine extract, in particular to a preparation method of acanthopanax saponin extract. Background technique [0002] Acanthopanax is the dry rhizome of Radix Acanthopanacis Senticosi, which has attracted the attention of scholars at home and abroad because of its wide range of physiological activities. The main components of Acanthopanax senticosus are triterpene saponins, especially zidonolic acid saponins, and nearly 20 saponins have been found. The total saponins of Acanthopanax senticosus have the effects of nourishing and strengthening, nourishing qi and invigorating the spleen, strengthening the body, strengthening the body, calming the nerves, etc. It is an immune enhancer that can regulate the body's metabolism and enhance the body's resistance to various diseases. For the extraction of Acanthopanax saponins, the traditional process is to extract the decoction pieces of A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/254A61K9/08A61K9/14A61K9/16A61K9/20A61K9/48A61P25/20A61P37/04A61K125/00A61K135/00
Inventor 杨悦武叶正良郑永锋李旭
Owner TIANJIN TASLY ZHIJIAO PHARMA
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