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A method for extracting and separating six dihydrotriphenylene alkaloids from Xiaoguoboluohui

A technology of dihydrotriphenanthridine and small fruit bob fallback, applied in the direction of organic chemistry, can solve the problems of complex chemical components, difficult separation of active components, and few separations of high-purity alkaloids, so as to improve resource utilization Utilization, extraction and separation efficiency are high

Active Publication Date: 2020-08-14
HUNAN AGRICULTURAL UNIV
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  • Claims
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Problems solved by technology

The chemical composition of the fruit drop is complex, and it is difficult to separate the active components. At present, there are many reports on the determination of the alkaloid content in the small fruit drop, but there are few reports on the separation of specific high-purity alkaloids.

Method used

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  • A method for extracting and separating six dihydrotriphenylene alkaloids from Xiaoguoboluohui
  • A method for extracting and separating six dihydrotriphenylene alkaloids from Xiaoguoboluohui
  • A method for extracting and separating six dihydrotriphenylene alkaloids from Xiaoguoboluohui

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Embodiment 1

[0040] Extraction: fresh small fruits falling back to the stems and leaves (moisture content about 76.33%) are chopped, extracted with 800L 95% ethanol at room temperature for 60h, filtered to obtain the ethanol extract, and the solvent is recovered under reduced pressure at 40°C (the ethanol concentration is about was 72%) to obtain an aqueous solution (about 45 L), and the residue was refluxed at 80° C. for 2 hours to obtain a refluxed extract, which was concentrated under reduced pressure at 60° C. to obtain 3 kg of extract.

[0041] Enrichment: add an equal amount of silica gel (3kg, 100-200 mesh) to the extract, stir, and mix into a powder. First, add about 7.5L of petroleum ether, stir well, and then let it stand for 20min. Collect the supernatant, 50 ℃ for recovery under reduced pressure, and the recovered petroleum ether was extracted again, adding 2.5 L of petroleum ether each time, and extracted for a total of 10 times until the color of the extraction solution was li...

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Abstract

The invention discloses a method for extracting and separating six dihydrobenzophenanthridine alkaloids from macleaya cordata. The method comprises the following steps: carrying out solvent extraction, concentration, separation and purification on macleaya cordata raw materials to obtain 6-(2'-ethyl formate)dihydrosanguinarine, 6-(2'-ethyl carboxylate)dihydrochelerythrine, 6-methyl carboxylate dihydrosanguinarine, 6-ethyl carboxylate dihydrosanguinarine, 6-(2'-ethyl carboxylate)dihydrosanguinarine and 6-ethyl isocarboxylate dihydrosanguinarine. According to the method, the six dihydrotriphenanthridine alkaloids are successfully extracted and separated from macleaya cordata, the extraction and separation efficiency is high, and the purity of the obtained alkaloids is high. According to themethod, the resource utilization of macleaya cordata is improved, and an effective way is provided for cognitive research and extraction separation of active ingredients of new drugs.

Description

technical field [0001] The invention relates to a method for extracting alkaloids from Macleaya microcarpa (Macleaya microcarpa (Macleaya microcarpa (Maxim.) Fedde) ), in particular to the separation and purification of four new dihydrotrihydrotriphenanthridine alkaloids 6- (2'-Ethyl carboxylate)sanguinarine, 6-methyl carboxylate sanguinarine, 6-ethyl carboxylate sanguinarine, 6-ethyl isocarboxylate dihydro Sanguinarine and 2 known dihydrotriphenylene alkaloids (6-(2'-carboxyethyl)dihydrochelerythrine and 6-(2'-carboxyethyl) The method of dihydrosanguinarine) belongs to the field of extraction and separation of natural medicines. Background technique [0002] Xiaoguoboluohui belongs to the genus Papapyraceae Boluohui, a large perennial herbaceous plant, mainly distributed in Henan, Shaanxi, Guizhou, Sichuan and other provinces and regions. In the natural state, it grows on hillsides, riversides or ditch banks at an altitude of 500 to 1500 meters. The main active ingredien...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D491/056C07D491/153
CPCC07D491/056C07D491/153
Inventor 曾建国刘兆颖林莉
Owner HUNAN AGRICULTURAL UNIV
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