Nasal cavity immunity composite adjuvant for avian influenza inactivation antigen

A technology of inactivating antigen and immune compounding, which is used in antiviral agents, antibody medical ingredients, medical preparations containing active ingredients, etc., to achieve the effects of improving whole body humoral immunity, improving immune effect, and reducing the stress response of chickens.

Inactive Publication Date: 2007-12-12
NANJING AGRICULTURAL UNIVERSITY
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Problems solved by technology

However, nasal immunization with inactivated vaccines alone c...

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  • Nasal cavity immunity composite adjuvant for avian influenza inactivation antigen
  • Nasal cavity immunity composite adjuvant for avian influenza inactivation antigen
  • Nasal cavity immunity composite adjuvant for avian influenza inactivation antigen

Examples

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Embodiment Construction

[0036] Sodium cholate, CpG DNA and avian influenza H5N2 inactivated antigen were combined with SPF chickens to nasally immunize SPF chickens. Each chicken (approximately 700 g): CpG 50μg+sodium cholate 20μg, to study the effect on the local and systemic immune levels of the chicken respiratory tract. First of all, the first phase of the project was tested. Apply CpG DNA separately according to plan (see references for extraction methods: Cui Yibang, He Kongwang, Lu Chengping, Guo Aizhen. The immune enhancement effect of bacterial CpGDNA on chickens inoculated with avian influenza virus H9 subtype inactivated vaccine. Chinese Journal of Veterinary Medicine 2005 25(2): 135~ 137). Sodium cholate is a mucosal immune adjuvant combined with avian influenza inactivated antigen (purchased from the Animal Quarantine Institute of the Ministry of Agriculture).

[0037] The above nasal mucosal immune complex adjuvants were combined with avian influenza inactivated antigens to immunize healthy...

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Abstract

The invention relates to compound intranasai immunization adjuvant used for deactivated avian influenza antigen, belongs to biotechnical field, and is special for the application of deactivated avian influenza antigen. The compound adjuvant is mixed or combined by CpG DNA and sodium cholate according to weight ratio of 5:2 according to dosage of immunological adjuvant of 0.1mg/kg. through combining with deactivated avian influenza antigen and intranasai immunization, the inventive compound intranasai immunization adjuvant used for deactivated avian influenza antigen can effectively local immunity of mucous membrane and humoral immunity of whole body, avoid immunization schedule through intramuscular injection, reduce stress reaction of chickens, provide guarantee for improving chicken quality, and provide an ideal Immunization approach for prevention of avian influenza.

Description

1. Technical Field [0001] The invention relates to a nasal cavity immune composite adjuvant used for avian influenza inactivated antigen, which belongs to the field of biotechnology, and is dedicated to the immune effect of nasal cavity mucosal immunity of the avian influenza inactivated antigen. 2. Background technology [0002] 1 Features of respiratory mucosal immunity [0003] The physiological environment of the nasal cavity is mild, and the threshold of antigen-induced immune response is relatively low. Some studies have found that nasal immunity can effectively stimulate local immune responses and induce systemic immune responses. Therefore, nasal immunity has attracted more and more attention from immunologists. Many studies have reported that nasal immunity can induce higher levels of specific antibodies in the respiratory tract. But the inactivated vaccine alone can not effectively stimulate the body to produce immune response through nasal immunization. Recently, it ha...

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Application Information

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IPC IPC(8): A61K39/39A61P31/16A61K39/145
Inventor 杨倩张晓文
Owner NANJING AGRICULTURAL UNIVERSITY
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