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Cockroach extractive for treating cardiovascular disease, preparation method and its composition

An extract, cardiovascular technology, applied in cardiovascular system diseases, drug combination, drug delivery, etc., can solve the problems of inaccurate cognition of the effective components of cockroach, low level of extraction technology, unsuitable for large-scale production, etc. Conducive to environmental protection, shortening production cycle, and saving production time

Inactive Publication Date: 2008-04-09
SHENZHEN SALUBRIS PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cockroach has gradually become a hot spot in the field of medicine, but the research on its active substances and the preparation technology of the active composition have not been developed accordingly. As a result, the preparation of pharmaceutical preparations for cockroaches does not meet the requirements of large-scale production, and the medical value of cockroaches has not been fully utilized.

Method used

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  • Cockroach extractive for treating cardiovascular disease, preparation method and its composition
  • Cockroach extractive for treating cardiovascular disease, preparation method and its composition
  • Cockroach extractive for treating cardiovascular disease, preparation method and its composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1, take water as extraction solvent preparation

[0041] 1. Crush the cockroach to ≤1mm, add 4 times the amount of double distilled water in the sandwich pot, and circulate the rubber mill for 60 minutes under the cooling state of ice water.

[0042] 2. Adjust the pH to 4.0 with HCL.

[0043] 3. Pass steam to 90°C and keep stirring for 90 minutes, cover and seal while hot, and let stand overnight.

[0044] 4. Keep the liquid temperature at 10°C and centrifuge at 4200r / min. Take the supernatant. Take out the precipitate, add 1 times the amount of double-distilled water, heat to 90°C for 20 minutes, cool and centrifuge. Combine the supernatants.

[0045] 5. Slowly add HCL to the above supernatant while stirring to adjust the pH to 4.0. Heat to a slight boil in a jacketed pot, then stop heating.

[0046] 6. Immediately pour it into a stainless steel pot with a cover while it is hot, cover it tightly, and let it stand overnight.

[0047]7. The next day, ta...

Embodiment 460

[0074] Embodiment 460% methanol preparation

[0075] The reaction conditions and steps are the same as the 60% ethanol extraction, and the reaction temperature that needs to be heated is strictly controlled, and the airtightness of the experimental equipment should be paid attention to throughout the experiment.

Embodiment 540

[0076] Embodiment 540% methanol extraction

[0077] The reaction conditions and steps are the same as the 40% ethanol extraction, and the reaction temperature that requires heating is strictly controlled. During the whole experiment, attention should be paid to the airtightness of the experimental equipment.

[0078] Embodiment 6 is prepared with 30% ethanol as extraction solvent

[0079] 1. Crush the cockroach to ≤1mm, add 3 times the amount of 30% ethanol solution, and circulate the rubber mill for 80 minutes under ice water cooling.

[0080] 2. Adjust the pH to 4.0 with HCL.

[0081] 3. Heat to 80°C in the condensing reflux device, keep stirring for 90 minutes, cover and seal while it is hot, and let stand overnight.

[0082] 4. Centrifuge at 4200r / min to maintain the liquid temperature at 0°C. Take the supernatant. Add 1 times the amount of extraction solvent to the precipitate, and centrifuge. Combine the supernatants.

[0083] 5. Slowly add HCL to the above supern...

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Abstract

The invention relates to extractive taking blattaria used as the medical source and being applied to the angiocarpy field, the preparation method thereof and a composition containing the extractive and pharmaceutically acceptable carrier. The extractive adopts water, alcohol and / or methanol as the extracting dissolvent, wherein, the volume concentration of the aqueous solution of the alcohol and / or methanol is 0 less than or equal to V / V less than or equal to 60 percent. The extractive has the advantages that blood fat is reduced, cholesterin is reduced, angina pectoris is prevented, the heart is tonified, and heart failure is resisted. The extraction process of the invention is simple and highly effective, the specialization is strong, and the obtained product has high effective component content. The extractive of the invention can be produced to be the composition containing the extractive and the pharmaceutically acceptable carrier.

Description

technical field [0001] The present invention relates to an extract applied in the cardiovascular field, a preparation method and a composition thereof, in particular to an extract applied in the cardiovascular field using cockroaches as a drug source, a preparation method and a medicinal product containing the extract The composition of the carrier. Background technique [0002] Cockroaches, commonly known as cockroaches, are also known as stone ginger, negative plate, slippery insect, tea woman insect, and fragrant lady. Belonging to the class Insecta and the order Blattata, there are about 2,300 species in the world, mostly distributed in tropical and temperate regions. Common species include German cockroaches, oriental cockroaches, Australian cockroaches, and American cockroaches. The body of the cockroach is oblong, and the back and abdomen are flat. The head is small and flexible, hidden under the front chest, and protrudes obliquely backward and downward. Mouthpar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61K9/00A61P9/04A61P9/10
Inventor 叶澄海
Owner SHENZHEN SALUBRIS PHARMA CO LTD
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