Preparation for specificity anticoagulant substance and application thereof

A technology of anticoagulation and thrombin, applied in the prevention and treatment of thrombosis-related diseases, the protein structure and preparation of anticoagulant substances, can solve the problem of no anticoagulant activity
CN101190945AInactive Publication Date: 2008-06-04INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
Publication Date
2008-06-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an anticoagulant protein containing an oligopeptide which is identified and cracked by thrombin or blood coagulation factor Xa; more particularly, the invention relates to a new anticoagulant substance connected by an anticoagulant substance and an amino acid sequence which can be identified and cracked by thrombin or blood coagulation factor Xa, or a new substance connected by an anticoagulant substance and other substances through taking an amino acid sequence which can be identified and cracked by thrombin or blood coagulation factor Xa as oligopeptide, as well as medicine science application of these new anticoagulant substances.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, and relates to a protein structure of an anticoagulant substance, a preparation method thereof and an application in preventing and treating thrombosis-related diseases. Specifically, the present invention relates to a new substance formed by linking an anticoagulant substance with an amino acid sequence that can be recognized and cleaved by a certain coagulation factor (including thrombin, coagulation factor Xa, etc.), or an anticoagulant substance and other substances through New substances formed by linking amino acid sequences that can be recognized and cleaved by a blood coagulation factor, and the medical use of these new substances. Background technique

[0002] Cardiovascular disease is the number one killer that threatens human health and life in recent years. Thrombosis is an important cause of many cardiovascular diseases. Anticoagulants are important drugs for preventing and treating thro...

Claims

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