Method for removing aristolochic acid from Chinese medicine and limit standard thereof

A technology of aristolochic acid and aristolochic acid salts, which is applied in the fields of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc.
CN101264116AInactive Publication Date: 2008-09-17INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
Publication Date
2008-09-17
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention relates to a method of removing the toxic ingredient of aristolochic acid from Traditional Chinese Medicine and the corresponding limit standard. Being aimed at the traditional Chinese medicinal materials containing aristolochic acid, the method is to obtain the processed medical herb in pieces with more than 99% f removal rate for the aristolochic acid after the process of repeated soaking - rinsing with weak acid strong alkali saline water and soaking - rinsing with clear water, draining and then vinegar baking. The invention is characterized in that the method can realize the purpose of selectively removing the toxic ingredient of aristolochic acid from the traditional Chinese medicine through the particular processing way, meanwhile, the limit standard of aristolochic acid is also formulated passing the systematical evaluation.
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Description

technical field

[0001] The invention belongs to the field of traditional Chinese medicine research, and in particular relates to a method for removing aristolochic acid in traditional Chinese medicine and its limit standard. technical background

[0002] Aristolochic acids are a series of nitrophenanthrene compounds, commonly found in plants of the genus Aristolochias pp. and Asarum spp. Sour traditional Chinese medicine can cause aristolochic acid nephropathy. The State Food and Drug Administration cancels the medicinal standards of Guan Mu Tong, Guang Fang Ji, and Qing Mu Xiang, and stipulates that Mu Tong, Fang Ji, and Tu Mu Xiang can be used instead of medicinal or clinical formulas. However, there are still many Chinese medicinal materials containing aristolochic acid used clinically, such as Aristolochia, Tianxianteng, Cinnabar lotus, Xugufeng, Asarum, etc., involving nearly 300 kinds of Chinese patent medicines, only relying on substitutes to replace the original Th...

Claims

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