Synthesis technique for toltrazuril

A technology of toltrazuril and a new process, applied in the directions of drug combination, organic chemistry, anti-infective drugs, etc., can solve the problems of difficulty in expanding the production capacity of enterprises, high hydrogenation reaction pressure, harsh process conditions, etc., and achieves low cost and raw materials. Easy-to-obtain, simple-to-equip effects
CN101265236AActive Publication Date: 2008-09-17HUBEI LONGXIANG PHARMA TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HUBEI LONGXIANG PHARMA TECH CO LTD
Publication Date
2008-09-17

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Abstract

The invention relates to the field of chemically synthesized drug, in particular to a new synthetic process of drug for preventing and curing poultry coccidiosis, i.e., toltrazuirl. The synthetic process includes allowing trifluoromethylthiophenol and 2-chloro-5-nitrotoluene as raw material to condense, performing the reduction reaction with hydrogen in presence of Pd / C catalyst, reacting with bis (trichloromethyl) carbonate for esterifying isocyanic acid, and finally adding diethyl carbonate and methylurea for synthesizing toltrazuirl. The new synthetic process of toltrazuirl has easy operation, simple required equipment, low pollution, easily the prior raw material, low cost, and high yield with a total one of up to about 50%.
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Description

technical field

[0001] The invention relates to the field of chemical synthesis drugs, in particular to a new synthesis process of toltrazuril, a drug used for the prevention and treatment of poultry coccidiosis. technical background

[0002] Toltrazuril is a triazinone anticoccidial drug developed by Bayer Company in Germany in the late 1980s. This product is mainly used for the prevention and treatment of fulminant coccidiosis. Poisonous, Eimeria tenella, Eimeria turkey glandularis, Eimeria turkey, Eimeria turkey minor all have killing effect.

[0003] Literature reports, the synthetic preparation technology of toltrazuril mainly contains following three kinds of methods:

[0004]

[0005] This is a synthetic route reported by US4874860. The raw materials used, such as methyl isocyanate and chlorocarbonyl isocyanate, are not easy to obtain directly from the market. If they are self-made, phosgene (carbonyl chloride) will be used. The safety hazard of industrial product...

Claims

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