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Use of brown algae polysaccharide sulfuric acid ester of low molecular weight in preparing medicine for treating diabetic nephropathy

A technology of diabetic nephropathy and fucoidan, applied in the field of application of low molecular weight fucoidan sulfate in the preparation of diabetic nephropathy drugs

Active Publication Date: 2012-03-14
青岛甚舒海洋科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature showing the use of low molecular weight fucoidan sulfate in the treatment of diabetic nephropathy

Method used

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  • Use of brown algae polysaccharide sulfuric acid ester of low molecular weight in preparing medicine for treating diabetic nephropathy
  • Use of brown algae polysaccharide sulfuric acid ester of low molecular weight in preparing medicine for treating diabetic nephropathy
  • Use of brown algae polysaccharide sulfuric acid ester of low molecular weight in preparing medicine for treating diabetic nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] After crushing seaweed, soak it in 3.7% formaldehyde solution overnight, then add distilled water and boil it for extraction, and filter the extract with diatomaceous earth, dialyze the filtrate with running water for one day, then dialyze with distilled water for one day, concentrate the dialysate, add ethanol to The concentration is 75% precipitation, and the precipitation is dried to obtain crude fucoidan sulfate ester. Redissolve the crude product in water at 0.05mol / L MgCl 2 In the presence of 20% ethanol precipitation to remove water-soluble alginate, the filtrate was dialyzed and concentrated, then 75% ethanol precipitated, and after drying, the purified fucoidan sulfate was obtained. Prepare four kinds of seaweed fucoidan sulfate esters according to the above method, and its chemical composition analysis is shown in the following table:

[0041]

[0042] Preparation of Low Molecular Weight Fucoidan Sulfate (hereinafter referred to as "Sample A")

[0043] We...

Embodiment 2

[0047] Take 50g of low molecular weight fucoidan sulfate, add 500ml of water for injection and 50g of mannitol, adjust the pH value to 7.0, subpackage, and freeze-dry.

[0048] Embodiment 3 Preparation of Low Molecular Weight Fucoidan Sulfate Tablets

Embodiment 3

[0049] Take 50g of low molecular weight fucoidan sulfate, add microcrystalline cellulose and polyvinylpyrrolidone, mix, add appropriate amount of water, make soft material, granulate, and dry. The granules are added with croscarmellose sodium and magnesium stearate, mixed, and pressed into tablets. Each tablet contains 10-200 mg of low molecular weight fucoidan sulfate.

[0050] Example 4 The therapeutic effect of low molecular weight fucoidan sulfate on diabetic nephropathy

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PUM

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Abstract

The invention discloses the application of a low-molecular-weight algal polysaccharide sulfate to the preparation of diabetic nephropathy drugs, wherein, the molecular weight of the low-molecular-weight algal polysaccharide sulfate is 15000 to 200000. Algal polysaccharide sulfate which is extracted from seatangle, fucus, bladder wrack, oarweed, or Chorda fiulm is processed through degradation, sothat the low-molecular-weight algal polysaccharide sulfate of the invention can be obtained.

Description

technical field [0001] The invention relates to the pharmaceutical use of low molecular weight fucoidan sulfate, in particular to the use of low molecular weight fucoidan sulfate in the preparation of medicines for treating diabetic nephropathy. Background technique [0002] Fucoidan sulfate is a class of sulfated polysaccharides that exist in brown algae and was first extracted from kelp palmate by Kylin in 1913 with dilute acid. Kylin separated the L-fucose after hydrolyzing the extract. He named this polysaccharide fucoidin. Now it is generally named fucoidan according to the naming principle of polysaccharides. The Chinese name is fucoidan, fucoidan, and fucoidan. , fucoidan sulfate, fucoidan or fucoidan sulfate. Now people have a relatively clear understanding of the composition of fucoidan sulfate esters. It is a type of polysaccharide with very complex chemical composition and structure. It is mainly composed of fucose and sulfate groups. Sugar, uronic acid and oth...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/737A61K36/02A61P3/10A61P13/12
Inventor 郝守祝李静
Owner 青岛甚舒海洋科技有限公司
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