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Chinese medicine composition for treating nephropathy

A composition and traditional Chinese medicine technology, applied in the field of medicine, can solve the problems of difficult quality control, unpredictable pharmacological effects, complex components, etc., and achieve the effects of good reproducibility, simple and easy extraction and purification methods, and significant curative effect.

Inactive Publication Date: 2008-12-03
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the choice of formula, the amount of dosage, and the difference in processing and preparation methods, traditional Chinese medicine compound prescriptions may produce unpredictable pharmacological effects. Controllable, safe and effective, less toxic and side effects, convenient to take, suitable for long-term use of traditional Chinese medicine has always been the focus of research

Method used

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  • Chinese medicine composition for treating nephropathy
  • Chinese medicine composition for treating nephropathy
  • Chinese medicine composition for treating nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Step 1. Preparation of hollyhock flower extract: take 7.5 kg of hollyhock flower and place it in an extraction tank, add 10% ethanol to extract 3 times, 75 L each time, and extract for 1 hour. Combine the extracts, let cool, filter, put the filtrate on a HPD-600 macroporous adsorption resin column, wash with water, discard the washing solution, elute with 90% ethanol, collect the eluate, concentrate under reduced pressure to 2L, add 10L of 95% ethanol Precipitate once, let it stand, filter, evaporate the filtrate to dryness, and grind the obtained solid into fine powder to obtain 189 g of marshmallow flower extract, wherein the content of hyperin is 25.1%, and the content of total flavonoids is 85.3%.

[0054] Step 2. Preparation of rhubarb extract: take 5 kg of rhubarb and grind them, add 10% ethanol to extract 3 times, 50 L each time, and extract for 1.5 hours. Combine the extracts, let cool, filter, put the filtrate on HPD-700 macroporous adsorption resin column, was...

Embodiment 2

[0057] Step 1. Preparation of the extract of hollyhock flower: take 300 kg of hollyhock flower and place it in an extraction tank, add 20% ethanol to extract 3 times, 1200 L each time, and extract for 0.5 hour. Combine the extracts, let cool, filter, put the filtrate on a HPD-100 macroporous adsorption resin column, wash with water, discard the washing solution, elute with 95% ethanol, collect the eluate, concentrate under reduced pressure to 60L, add 360L of 95% ethanol Precipitate once, let it stand, filter, evaporate the filtrate to dryness, and grind the obtained solid into fine powder to obtain 7670 g of marshmallow flower extract, wherein the content of hyperin is 18.6%, and the content of total flavonoids is 70.5%.

[0058] Step 2. Preparation of rhubarb extract: Take 100 kg of rhubarb and grind it as appropriate, add 35% ethanol to extract twice, each time 600 L, extract for 2 hours. Combine the extracts, let cool, filter, put the filtrate on HPD-450 macroporous adsorp...

Embodiment 3

[0061] Step 1. Preparation of the extract of hollyhock flower: take 30 kg of hollyhock flower and place it in an extraction tank, add 25% ethanol to extract 3 times, 120 L each time, and extract for 1 hour. Combine the extracts, let cool, filter, put the filtrate on HPD-100 macroporous adsorption resin column, wash with water, discard the washing solution, elute with 95% ethanol, collect the eluate, concentrate under reduced pressure to 6L, add 36L of 95% ethanol Precipitate once, let it stand, filter, evaporate the filtrate to dryness, and grind the obtained solid into fine powder to obtain 513g of marshmallow flower extract, wherein the content of hyperin is 15.6%, and the content of total flavonoids is 68.8%.

[0062] Step 2. Preparation of rhubarb extract: Take 20 kg of rhubarb and grind them into pieces, add 30% ethanol to extract 3 times, 100 L each time, and extract for 1 hour. Combine the extracts, let cool, filter, put the filtrate on HPD-100 macroporous adsorption re...

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Abstract

The invention provides a Chinese traditional medicine composition for treating kidney diseases and a preparation method thereof. In the composition, rhubarb and flower of abelmoschus manihot which are used as formula compositions are extracted respectively and mixed, and the mixture and drug carriers are mixed to prepare a proper formulation for use. The Chinese traditional medicine composition of the invention has obvious curative effect on kidney diseases, in particular diabetic nephropathy. The preparation method of the invention has good repeatability and is suitable for industrialized production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating nephropathy and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Nephropathy is a group of urinary system diseases that seriously endanger people's health. Most of them have recurrent attacks, are protracted and difficult to heal, and are very difficult to treat. Especially when the kidney disease goes through multiple episodes and the condition is not controlled or treated effectively, it may develop into renal failure and eventually uremia. And once it evolves into uremia, it means indirectly declaring that the patient's kidneys are about to completely lose their function. It is called a silent killer disease by medical scientists, and it has gradually increased in recent years. [0003] The so-called kidney disease mainly refers to primary glomerular diseases, such as acute glomerulonephritis, nephrotic syndrome, occult g...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61P3/10A61P13/12
Inventor 石赟蓉杨永安徐宏江郭安军宋伟
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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