Polypeptide having specific combination with neoplasm metastasis cell and uses thereof
A tumor metastasis and specific technology, applied in peptides, instruments, analytical materials, etc., can solve the problems of high background value, unknown, large non-specificity, etc.
Inactive Publication Date: 2010-12-01
NANKAI UNIV
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Problems solved by technology
Our solution overcomes some problems in previous cell screening, mainly that the cell surface components are complex and unknown, the non-specificity of cell screening is large, the background value is high, and the cell surface difference between metastatic and non-metastatic tumor cells is small
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The invention relates to polypeptide combined with the specificity of tumor metastasis cells, as well as an application thereof. The amino acid sequence of the polypeptide combined with the surface antigen specificity of the tumor metastasis cells is Leu-Pro-Trp-Lys-Glu-Pro-Tyr-Tyr-Leu-Met-Pro-Pro. The polypeptide has the characteristics that the polypeptide is combined with the specificity of the tumor metastasis cells and inhibits the movement of the tumor metastasis cells. Therefore, the polypeptide can be used as a diagnosis marker for tumor metastasis, and can be applied to develop precursors for tumor metastasis inhibiting medicine.
Description
Polypeptide specifically binding to tumor metastatic cells and application thereof technical field The invention belongs to the technical field of bioengineering and biomedicine, and relates to the use of phage display technology to screen polypeptides that can specifically bind to surface antigens of tumor metastases, specifically, the differential screening of random 12-peptide phages using in situ tumors and tumor metastases cell lines Display the library to obtain specific 12-peptide sequences that can be used as tumor metastasis markers. Background technique Tumor cells invade lymphatic vessels, blood vessels or body cavities from the original site, migrate to other places and continue to grow, forming tumors of the same type as the primary tumor, which is called metastasis [Yang Guanghua et al. "Pathology" (fifth edition), People's Health Press, 2001, P87). Finding the abnormal expression of various molecules on the surface of tumor cells from the molecular level i...
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IPC IPC(8): G01N33/574C07K7/08
Inventor 张翠竹张宏恺李鑫曹又佳
Owner NANKAI UNIV