Chinese medicinal composition for treating common cold, acute and chronic tracheitis and preparation method thereof

A technology for chronic bronchitis and composition, applied in the pharmaceutical composition of chronic bronchitis and preparation thereof, in the treatment of colds and acute fields, and can solve problems such as toxic and side effects

Active Publication Date: 2008-12-24
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the pathogens are viral infections. Since antibiotics are ineffective in treating viral infections and have different degrees of toxic and side effects, it is an urgent task for pediatric medical workers to find a safe, effective, and non-toxic drug.

Method used

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  • Chinese medicinal composition for treating common cold, acute and chronic tracheitis and preparation method thereof
  • Chinese medicinal composition for treating common cold, acute and chronic tracheitis and preparation method thereof
  • Chinese medicinal composition for treating common cold, acute and chronic tracheitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0034] Experimental example 1: the effect of the pharmaceutical composition of the present invention on the body temperature of dry yeast-induced fever rats

[0035] Male SD rats were used to adaptively measure their anal temperature once a day for 3 consecutive days. They were fasted for 12 hours before the formal experiment, and their anal temperature was measured twice in the next morning with an interval of 1 hour. The average temperature was taken as normal body temperature. 0.3 ℃ rats are qualified rats, subcutaneous injection of 20% yeast suspension 10ml / kg on the back of each mouse, 60 rats with fever above 1 ℃ were selected after 6 hours, and randomly divided into 6 groups, namely blank control group (equal volume distilled water), Composition A low dose group (14g / kg), composition A high dose group (28g / kg), composition B low dose group (17g / kg), composition B high dose group (34g / kg), aspirin group (0.2g / kg), the rats in each group were administered with 10mL / kg ora...

experiment example 2

[0040] Experimental Example 2: Effect of the pharmaceutical composition of the present invention on the writhing response of mice induced by acetic acid

[0041] Get 60 Kunming mice of 18 to 22, half male and half male, and be randomly divided into 6 groups, 10 in every group, i.e. blank control group (equal volume distilled water), composition A low dose group (20g / kg), Composition A high-dose group (40g / kg), composition B low-dose group (24g / kg), composition B high-dose group (48g / kg), aspirin group (0.2g / kg), each group of mice with 20mL / kg intragastric administration, 1h after administration, intraperitoneal injection of 0.7% acetic acid, 0.2ml / mouse, immediately began to observe and record the number of times of mouse writhing within 20min, the writhing reaction is expressed as abdominal concave, stretching The raising of the hind limbs and buttocks is the standard count, and the results are shown in Table 2:

[0042]Table 2: Effect of the pharmaceutical composition on t...

experiment example 3

[0046] Experimental example 3: the influence of the pharmaceutical composition of the present invention on the permeability of mouse peritoneal capillaries

[0047] Get 60 Kunming mice aged 18 to 22, half male and half female, grouping and administration are the same as in Experimental Example 2, inject 0.5% Evans blue normal saline solution 0.1ml / 10g body weight intravenously 1h after administration (not one injection once) The mice injected with Evans blue normal saline solution were discarded), then intraperitoneally injected 0.7% acetic acid, 0.2ml / mouse, and after 20min, the mice were killed by dislocation of the cervical spine, the abdominal skin and muscles were cut open, and 10ml of normal saline was used several times Wash the peritoneal cavity, absorb the washing liquid and merge it into 10ml, centrifuge at 3000 rpm for 15min; take the supernatant and measure its absorbance at 590nm with a 752-type spectrophotometer, and the results are shown in Table 3:

[0048] Tab...

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PUM

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Abstract

The invention discloses a Chinese medicine combination for remedying cold, acute and chronic tracheitis and a preparation method thereof. The medicine combination is made from the raw materials with the following weight portions of 8-12 portions of antelope horn, 30-60 portions of bulbus fritillariae ussuriensis, 20-40 portions of rhubarb, 10-20 portions of scutellaria, 10-20 portions of lapis chloriti, 15-30 portions of plaster stone, 5-15 portions of artificial calculus bovis and 20-40 portions of licorice.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating colds and acute and chronic bronchitis and a preparation method thereof. Background technique [0002] Infantile bronchitis and bronchopneumonia belong to the category of pulmonary diseases in Chinese medicine, and cough with phlegm heat is one of the main syndromes in pulmonary diseases. It is mostly caused by wind-cold or wind-heat invading the lungs, endogenous phlegm turbidity, stagnation and heat transformation, and loss of ventilation and descending of the lungs. The clinical manifestations are cough, thick phlegm, thirst, sore throat, and even shortness of breath, nasal flaring, yellow thick tongue coating and other syndromes of lung heat. [0003] Infantile bronchitis and bronchial pneumonia are common and frequently-occurring diseases in pediatrics. Most of the pathogens are viral infections. Since antibiotics are ineffective in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61P11/00A61P31/00A61K33/06A61K33/12A61K35/12A61K35/32A61K35/413
Inventor 肖伟戴翔翎凌娅沈静陈刚徐涟明
Owner JIANGSU KANION PHARMA CO LTD
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