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Bear bile buccal tablet and preparation process thereof

A technology of bear bile and bear bile powder, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, pill delivery, etc. It can solve the problems of easy deliquescence, single dosage form, easy moisture absorption, etc., and achieves convenient transportation and good taste , the effect of convenient use

Inactive Publication Date: 2009-01-07
FUJIAN JIANDONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Domestic existing preparations only have "bear bile capsule" as a single drug preparation, and most of the others are compound preparations; and health care products mainly include bear bile powder (medicinal material) and bear bile wine in small packages, but due to their extremely bitter taste, Fishy, ​​easy to deliquescence, its consumption is all less, and this has just greatly limited and weakened its remarkable treatment, the practical effect of health care; The method of coating after making granules is solved, but so far there is no report on the method of fundamentally solving its bitterness, fishy smell, and easy moisture absorption problems, so the dose-effect of bear bile cannot be brought into full play, and single-flavored bear bile A single form of Chinese patent medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0020] 50 g of bear bile powder and 250 g of beta-cyclodextrin were mixed, dissolved in 50% ethanol, stirred at 80° C. for 1 hour, and spray-dried to obtain a fine powder. Add 600g of sucrose powder, 70g of dextrin, and 3.6g of stevia, mix well, use 75% ethanol as a wetting agent to sieve to make 10 to 20 mesh granules, dry at 80°C until the water content of the granules is below 4%, menthol and Mix 5g of peppermint oil to dissolve, add appropriate amount of essence, spray evenly on the above-mentioned granules, add 7g of talcum powder and 3g of magnesium stearate, mix well, press into 1000 pieces, and the finished product is obtained, each piece weighs 1.0g, contains bear Bile powder 50mg.

example 2

[0022] 60 g of bear bile powder and 240 g of beta cyclodextrin were mixed, dissolved in 50% ethanol, stirred at 70° C. for 1.5 hours, and spray-dried to obtain a fine powder. Add 600g of sucrose powder, 70g of dextrin, and 3.6g of stevia, mix well, use 75% ethanol as a wetting agent to sieve to make 10 to 20 mesh granules, dry at 80°C until the water content of the granules is below 4%, menthol and Mix 5g of peppermint oil to dissolve, add appropriate amount of essence, spray evenly on the above-mentioned granules, add 7g of talcum powder and 3g of magnesium stearate, mix well, press into 1000 pieces, and the finished product is obtained, each piece weighs 1.0g, contains bear Bile powder 60mg.

example 3

[0024] 55 g of bear bile powder and 250 g of beta cyclodextrin were mixed, dissolved in 50% ethanol, stirred at 90° C. for 0.7 hour, and spray-dried to obtain a fine powder. Add 600g of sucrose powder, 65g of dextrin, and 3.6g of stevia, mix well, use 75% ethanol as a wetting agent to sieve to make 10 to 20 mesh granules, dry at 80°C until the water content of the granules is below 4%, menthol and Mix 5g of peppermint oil to dissolve, add appropriate amount of essence, spray evenly on the above-mentioned granules, add 7g of talcum powder and 3g of magnesium stearate, mix well, press into 1000 pieces, and the finished product is obtained, each piece weighs 1.0g, contains bear Bile powder 55mg.

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PUM

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Abstract

The invention relates to a bear gall buccal tablet and a preparation method thereof. The bear gall buccal tablet is prepared from the components of (by weight parts): bear gall powder 40-60, BETA-cyclodextrin 200-350, sucrose 500-600, dextrin 60-80, steviosin 3-5, menthol 4-6, peppermint oil 4-7, magnesium stearate 2-4, and talcum powder 5-8. The inventive product retains the original ingredients, natural physiological activity and specific therapeutic effects; and has the advantages of good mouthfeel, and convenience for transportation, storage, carrying and administration. The bear gall buccal tablet can be used for treating convulsion and throat swelling and pain, and has enhanced therapeutic effect on acute pharyngitis and gingivitis.

Description

Technical field: [0001] The invention relates to a bear bile buccal tablet and a preparation method thereof. Background technique: [0002] Bear bile is the bile of the Ursidae black bear (Selenaretos Thibeta Cuver) or brown bear (Ursus aretos). Bear bile is one of the most valuable medicinal materials in the treasure house of traditional Chinese medicine in my country, and it has been used in clinical practice for thousands of years. According to the classics of traditional Chinese medicine "Shen Nong's Materia Medica", "Tang Materia Medica", and "Compendium of Materia Medica", bear bile is bitter in taste, cool in nature, returns to the spleen, gallbladder, heart meridian, non-toxic, and has the functions of clearing heat, calming the liver, and improving eyesight; Convulsions and convulsions, external treatment of red eyes, swelling and pain, and sore throat; the dosage is 0.3-1 g, mostly in the form of pills and powder, appropriate amount for external use, powdered or m...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61K9/20A61K47/40A61P11/04A61P27/02A61P43/00
Inventor 王建忠
Owner FUJIAN JIANDONG PHARMA
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