Vascular aging-predicting factor and utilization of the same

A technology for aging prediction and blood vessels, applied in biological testing, measuring devices, chemical instruments and methods, etc.
CN101365718AInactive Publication Date: 2009-02-11NAGASAKI UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NAGASAKI UNIVERSITY
Publication Date
2009-02-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

It is intended to provide a factor which predicts vascular aging and a method of examining an early lesion caused by vascular aging. More specifically speaking, it is intended to provide: a factor predicting vascular aging which comprises human apolipoprotein B100 having a glutathionated thiol group; a method of examining a lesion caused by vascular aging which comprises measuring human apolipoprotein B100 having a glutathionated thiol group in a blood sample; an antibody capable of specifically recognizing apolipoprotein B100 having a glutathionated thiol group; and a diagnostic or a diagnostic kit for an early lesion caused by vascular aging which contains an antibody capable of recognizing human apolipoprotein B100 having a glutathionated thiol group.
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Description

technical field

[0001] The present invention relates to predictors of vascular aging and their use. Specifically, the present invention relates to a vascular aging predictor and a detection method thereof using glutathionylation of a specific sulfhydryl group of human apolipoprotein B100 as an index. Background technique

[0002] Among metabolic syndrome, which is expected to become more and more popular in the future, diabetes (impaired glucose tolerance), hypertension, hyperlipidemia, obesity, etc., which are underlying diseases of metabolic syndrome, generally function as accelerators of vascular aging. Vascular aging causes myocardial infarction and cerebral infarction through the formation of arteriosclerosis and arterial blockage. However, available objective indicators of vascular aging are those obtained by morphological measurements (eg, ultrasound diagnosis of carotid arteries), and a simple measurement method using patient serum as a sample has not yet been estab...

Claims

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