A strain of Rhodococcus and use thereof for preparing optical pure chiral sulphoxide

Abstract

The invention discloses a Rhodococcus (Rhodococcus sp.ECU0066) and the use thereof, and the culture collection number of the strain is CGMCC No.2547. The resting cells of the strain is taken as a biological catalyst, and prochiral phenyl alkyl sulfide and a derivative thereof are carried out catalytic oxidation asymmetrically to obtain benzoylate sulfoxide and a derivative thereof with optical activity. The strain and the stereoselective biological oxidation process have the advantages of better catalysis effect, simple and safe operation and low cost, the product is easily purified and is friendly to environment.

Description

technical field The invention belongs to the field of biochemical industry, and relates to a rhodococcus strain and its application for producing optical pure chiral sulfoxide. technical background Organosulfur compounds have been widely used in organic synthesis for a long time. Optically active sulfoxides are also increasingly used in asymmetric synthesis as an important tool for inducing many asymmetric transformations. Especially in the past 20 years, the application of chiral sulfoxide compounds as chiral auxiliary reagents in the field of asymmetric synthesis has shown exponential growth, and the role of chiral sulfoxide functional groups in the formation of carbon-carbon bonds and carbon-heterobonds has been established. Status as the most efficient and versatile chiral control factor. As one of the most successful and effective chiral control factors, chiral sulfoxide compounds have at least three favorable factors: (1) Chiral sulfoxide has high stereochemical sta...

AI Technical Summary

Problems solved by technology

However, these asymmetric oxidations of thioethers using the whole cell as a catalyst generally have low ee values, and it is difficult to meet the purity requirements in the synthesis process.

Images