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Package container for sodium bicarbonate injection and method of preparing the same

A sodium bicarbonate and packaging container technology, which is applied in the field of pharmaceutical packaging, can solve problems such as poor gas barrier performance and changes in the pH value of sodium bicarbonate injection, and achieve the effect of facilitating production and ensuring stability

Inactive Publication Date: 2009-04-08
HUNAN CHINASUN PHARMA MASCH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] If plastic bottles (bags) are used to pack sodium bicarbonate injection, since the plastic material (mainly polypropylene) used in the plastic bottles (bags) has poor gas barrier properties, the carbon dioxide decomposed from the aqueous solution of sodium bicarbonate The gas will seep out of the bottle (bag), and when the carbon dioxide gas in the bottle (bag) is lost, the aqueous solution of sodium bicarbonate in the bottle (bag) will decompose, causing the pH value of the sodium bicarbonate injection to change
[0007] Therefore, only glass bottles can be used at present, and plastic packaging cannot be used as packaging for liquid substances such as sodium bicarbonate injection.

Method used

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  • Package container for sodium bicarbonate injection and method of preparing the same
  • Package container for sodium bicarbonate injection and method of preparing the same
  • Package container for sodium bicarbonate injection and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] first make the figure 2 Shown plastic bottle 1; After the plastic bottle is cleaned, the sodium bicarbonate injection 3 that prepares is poured in the plastic bottle 1; Fill into carbon dioxide gas 4 while filling medicinal liquid, as image 3 Shown; Use combination cover 12 afterwards to be filled with liquid medicine and be full of the plastic bottle sealing of carbon dioxide gas 4, as Figure 4 shown; will Figure 4 The shown plastic bottle 1 is sealed in a protective bag 2 made of a high gas barrier film, and the air in the bag is drawn out before sealing to form an external vacuum environment of the plastic bottle 1, as shown in FIG. figure 1 shown; will be as figure 1 The packaging shown is sterilized at high temperature, and then the sterilized product can be packed after passing the light inspection.

Embodiment 2

[0055] first make the Image 6 Shown plastic inner bag 6; The sodium bicarbonate injection 3 that will prepare is poured in the plastic inner bag 6; Charge into carbon dioxide gas 4 while filling medicinal liquid, as Figure 7 Shown; Use combination cover 12 afterwards to be filled with liquid medicine and be full of the plastic inner bag 6 sealing of carbon dioxide gas 4, as Figure 8 shown; will Figure 8 The plastic inner bag 6 shown is sealed in the protective bag 2 made of high gas barrier film, and the air in the bag is drawn out before sealing to form a vacuum environment outside the plastic inner bag 6, as Figure 5 shown; will be as Figure 5 The packaging shown is sterilized at high temperature, and then the sterilized product can be packed after passing the light inspection.

Embodiment 3

[0057] first make the figure 2 Shown plastic bottle 1; After the plastic bottle is cleaned, pour the sodium bicarbonate injection 3 prepared in the plastic bottle 1; Fill into carbon dioxide gas 4 while filling medicinal liquid, as image 3 Shown; Use combination cover 12 afterwards to be filled with liquid medicine and be full of the plastic bottle sealing of carbon dioxide gas 4, as Figure 4 shown; will Figure 4 The plastic bottle shown is sterilized at high temperature; the sterilized plastic bottle is sealed in a protective bag 2 made of a high-barrier film, and the air in the bag is drawn out before sealing to form a vacuum environment outside the plastic bottle 1 ,Such as figure 1 shown. will be like figure 1 The products shown can be packed after passing the light inspection.

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PUM

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Abstract

The invention discloses a packaging container for sodium bicarbonate injection and a production method thereof. The packaging container comprises a first container and a second container, wherein the first container receives the sodium bicarbonate injection and is filled with carbon dioxide gas, the second container is made from a choke material, the first container is sealed and contained inside the second container, and the second container is vacuumized before being sealed. The production method comprises the following steps: providing the first container; filling the sodium bicarbonate injection in the first container; filling the carbon dioxide gas in the first container; sealing the first container; providing the second container made from the choke material; and arranging the sealed first container in the second container, and vacuumizing the second container before being sealed. The plastic package can ensure that the sodium bicarbonate injection filled inside the package does not decompose.

Description

technical field [0001] The invention belongs to the field of medical packaging, in particular to a packaging container for sodium bicarbonate injection and a production method thereof. Background technique [0002] In the field of pharmaceutical packaging, plastic packaging has been widely used for its good stability and low cost. [0003] However, some liquid medicines can only be packaged in glass bottles because glass bottles have high gas barrier properties. Taking the commonly used sodium bicarbonate injection as an example, because sodium bicarbonate injection is easily decomposed into sodium carbonate, carbon dioxide and water during storage, if this happens, the pH value of sodium bicarbonate injection will change, such as injection When it enters the human body, it will cause the pH value of the body fluid to be disturbed. The equation for the decomposition of aqueous sodium bicarbonate solution is: [0004] [0005] It can be seen from the above formula that ...

Claims

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Application Information

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IPC IPC(8): A61J1/10
Inventor 刘祥华彭勋德
Owner HUNAN CHINASUN PHARMA MASCH CO LTD
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