Construction method of blood capillary model and microsystem chip thereof

A microchip, chip technology, applied in the field of interdisciplinary, can solve the problem of not establishing capillary tissue structure and so on
CN101451105AInactive Publication Date: 2009-06-10SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
Publication Date
2009-06-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for constructing a blood capillary model and a microsystem chip thereof. The invention utilizes microsystem processing technology to design and manufacture a microchip system for ordered arrangement and culture of endothelial cells of a blood capillary. The method constructs the blood capillary model with normal physiological functions by the following three main steps: design and manufacture of the microsystem chip, transfer, arrangement, fixation and culture of the endothelial cells of the blood capillary, and measurement of the functions of the blood capillary model. The blood capillary model can be used for culturing and observing the endothelial cells of the blood capillary, can perform real-time measurement on the concentration of vasodilative factors NO excreted by the endothelial cells, can make the permeability of the tube wall changed along with different additional stimuli, approximately simulate the functions of the blood capillary under normal physiological conditions, and can be used for sieving active ingredients of cardiovascular drugs.
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Description

technical field

[0001] The invention relates to a method for constructing a capillary model and a microsystem chip thereof. The model is constructed based on microsystem technology combined with cell biology technology, and can be used in drug screening, tissue engineering, basic cell biology, etc., and belongs to the field of interdisciplinary technology . Background technique

[0002] Capillary is the end of the blood circulation. The capillary wall is mainly composed of a layer of endothelial cells (endothelial cells) and basement membrane (Basal Lamina). The thin capillary cross-section is surrounded by an endothelial cell, and the thick capillary Surrounded by 2 to 3 endothelial cells. Conventional capillary models generally use biodegradable materials as scaffolds to cultivate normal cells in the vessel wall, and spin culture reconstruction and regeneration to form tubular models. At present, a variety of tissue-engineered blood vessel construction models are being s...

Claims

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