Automatic voxel selection for pharmacokinetic modeling

A pharmacokinetic, automatic selection technology, used in image data processing, instrumentation, computing, etc.

Inactive Publication Date: 2009-07-15
KONINK PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So fitting voxels with high noise levels doesn't make sense at all

Method used

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  • Automatic voxel selection for pharmacokinetic modeling
  • Automatic voxel selection for pharmacokinetic modeling
  • Automatic voxel selection for pharmacokinetic modeling

Examples

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Embodiment Construction

[0030] figure 1 A flowchart is shown of an embodiment of a method for automatically selecting a preferred voxel from a set of voxels for pharmacokinetic modeling according to the present invention, wherein the voxels contain data points indicative of activity levels over time. The term voxel according to the present invention refers to a volume element or sample collected from a biological system containing said data. A voxel set may, for example, comprise several samples that have been collected from the biological system. The biological system can be, for example, a human or animal body, or any kind of biological species. The term pharmacokinetic modeling refers according to the present invention to the study of the absorption and / or disposal of a drug or compound by a biological system, wherein it explores how the drug / compound is handled by the biological system. Thus, the absorption may relate to the amount of the drug / compound dose that enters the biological system dur...

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Abstract

This relates to a method of automatically selecting preferred voxels from a group of voxels for pharmacokinetic modeling of a biological system, where the voxels contain data points indicating a change of activity-levels over time. For each respective voxel the changes of the data points over time with at least one noise level value, where the comparing is performed in accordance to a pre-defined selection rule. Then, those voxels where the result of the comparing obeys the selection rule are then selected as preferred voxels.

Description

technical field [0001] The present invention relates to a method and apparatus for automatically selecting preferred voxels from a set of voxels for pharmacokinetic modeling, wherein the voxels contain a time series of data points indicative of activity levels over time. The invention also relates to the use of the method for the analysis of the absorption or disposal of a drug or compound in an organism or biological system. Background technique [0002] The term pharmacokinetics refers to the branch of pharmacology that specializes in the study of the time course of substances and their relationship to an organism or system. This discipline is primarily concerned with pharmaceutical substances and contrast agents, but is also concerned with a wide variety of compounds present in biological systems. [0003] An important aspect of the routine use of pharmacokinetic modeling in the clinical setting is the time required to perform such an analysis. In this context, the work...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T7/00
CPCG06T2207/30004G06T2207/10076G06T7/0012
Inventor T·保卢斯M·C·文格勒
Owner KONINK PHILIPS ELECTRONICS NV
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