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Medicament for treating radiation injury and preparation method thereof

A radiation injury and medicine technology, applied in the field of medicine for treating radiation injury and its preparation, can solve the problems of no independent intellectual property rights, large toxic and side effects, etc.

Inactive Publication Date: 2010-12-29
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0004] Therefore, the study of drugs for the prevention and treatment of radiation injury has important practical value and practical significance for us. However, most of the drugs currently used clinically in my country to prevent and treat radiation injury are chemically synthesized drugs, which have large toxic and side effects and have no independent intellectual property rights. Therefore, Development of natural medicines for radiation injury is needed

Method used

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  • Medicament for treating radiation injury and preparation method thereof
  • Medicament for treating radiation injury and preparation method thereof
  • Medicament for treating radiation injury and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0016] Example 1: Animal experiments

[0017] 1 Materials and methods

[0018] 1.1 Experimental animal health 50 SPF grade Kunming mice, male, weighing 18-22g, 6-8 weeks old, half male and half male, were provided by the Experimental Animal Center of our school.

[0019] 1.2 For irradiation conditions 60 Uniform whole body irradiation with Co-γ ray at one time, dose rate 3.2s / cGy, irradiation field 25cm×25cm, SSD 80cm, irradiation dose 6Gy, our school 60 Co irradiation center performed.

[0020] 1.3 Methods Mice were randomly divided into 5 groups, 10 in each group. Experimental group: given 60 Coγ-ray 6Gy one-time whole-body irradiation, on the second day after irradiation, 1.0g / kg / d (high-dose group), 0.5g / kg / d (middle-dose group) and 0.25g / kg / d (low-dose group) were administered respectively. ) by gavage for 15 consecutive days. A negative control group (normal saline) and an irradiation control group ( 60 Coγray 6Gy irradiation + normal saline).

[0021] 1.4 Observ...

example 2

[0048] Example 2: Clinical Trials

[0049] 50 people from a long-wave radio station (navigation station) in Guangxi, and 45 people from a certain garrison. After taking the medicine for two courses of treatment a month, it can improve the nervous system symptoms of the staff (weakening memory, vision loss, irritability, fatigue, insomnia). Vascular symptoms (palpitation, shortness of breath), hair loss and other effects. It can significantly improve dizziness, irritability, memory loss, and weight loss, and can significantly improve white blood cells and platelets.

[0050] Through the above animal tests and some clinical observations, it is found that the present invention has a good symptomatic treatment effect on radiation damage, and animal tests prove that it has no toxic effect and can be used safely.

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Abstract

The invention provides a drug for treating radiation injury and a method for preparing the same, and belongs to the field of traditional Chinese medicine preparation process. The traditional Chinese medicines are used as raw materials to prepare the drug through extraction of a formulation. The drug is characterized in that the drug consists of four medicinal materials in portion by weight: 5 to 15 portions of integripetal rhodiola herb, 15 to 25 portions of astragalus root, 5 to 15 portions of acanthopanax root extract and 80 to 100 portions of sea backthern. The preparation method comprisesthat: the astragalus root and the sea backthern are mixed, are decocted with water for two times, and are filtered; the filtrate is combined and is condensed to extract with relative density of between 1.28 and 1.30 (80 DEG C); and the extract, the acanthopanax root extract and pulverized integripetal rhodiola herb fine powder are mixed and evenly stirred, are dried at temperature of 60 DEG C, are pulverized, are filtered by a 80-mesh sieve, and are pelletized into particles; and the particles are dried at temperature of less than 80 DEG C, and are capsulated into a No. 0 capsule to obtain the drug. The clinical test and experimental research show that the drug has the function of treating the radiation injury, and has no obvious adverse reaction, abundant sources of the raw materials, and low production cost.

Description

Technical field [0001] The invention belongs to a medicine for treating radiation damage and a preparation method thereof, in particular to a medicine for treating radiation damage mainly composed of extracts of rhodiola rosea, astragalus, acanthopanax extractum and seabuckthorn. Background technique [0002] With the development of science and technology, electromagnetic radiation is more and more in our lives, such as various radio and television equipment, mobile computer products, household appliances radiation, and X-ray perspective, CT, nuclear magnetic resonance and tumors widely used in medicine Patients need long-term radiation therapy. In addition, more and more radiation is emitted from building materials. With the acceleration of nuclear power plant construction, potential nuclear radiation cannot be ignored. [0003] All kinds of radiation (radiation) can cause nervous, cardiovascular, respiratory and other system stress reactions, such as blurred vision, nervou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/481
Inventor 李予蓉孙纪元王四旺王晋曾丽华李康樗郭国祯
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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