Diacerein composition with good leaching property, and preparation and use thereof

A technology of diacerein and composition, applied in the field of diacerein composition, can solve problems such as affecting the storage stability of the composition, increase in impurity content, etc., and achieve excellent dissolution performance, effective therapeutic concentration, and obvious clinical advantages. Effect
CN101537002BInactive Publication Date: 2012-02-29安士制药(中山)有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
安士制药(中山)有限公司
Publication Date
2012-02-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a diacerein composition with good leaching property, and preparation and a use thereof. The diacerein composition consists of diacerein and pharmaceutically acceptable adjuvants. The pharmaceutically acceptable adjuvants are selected from one or more from starch, microcrystalline cellulose, lactose, a disintegrating agent, a lubricant, an edulcorant and an adhesive. The diacerein composition quickly enters a blood circulation system more easily than an imported diacerein capsule, has better storage stability and is suitable for application to preparing drugs for preventing and treating arthritis, nephritis, glomerulonephritis and psoriasis as well as an interleukin-1 inhibitor.
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Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to provide a diacerein composition with excellent dissolution performance, its preparation and application. Background technique

[0002] Diacerein is a new interleukin (IL-1) inhibitor. Its mechanism of action (1) inhibits the activity of IL-1; (2) inhibits the synthesis of IL-1 in synovial tissue; (3) inhibits the expression of IL-1 receptor in chondrocytes; (4) inhibits collagenase and matrix dissolution (5) Promote the synthesis of collagen and amino polysaccharides; (6) Inhibit the chemotaxis of leukocytes and stabilize lysosomes.

[0003] Clinical studies have shown that diacerein can significantly relieve symptoms and effectively modify the structure, and is a slow-acting drug that changes the symptoms and condition of osteoarthritis. All relevant trials have shown that diacerein can significantly improve the joint function of patients with osteoarthritis, delay the course...

Claims

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