Disinfectant for animals and preparation method thereof

The technology of a disinfectant and a chelating agent is applied to the compound veterinary disinfectant containing glutaraldehyde and mono- and double-chain quaternary ammonium salts and the field of preparation thereof, which can solve the problem that the quaternary ammonium salt has a narrow bactericidal spectrum, cannot kill mycoplasma, and cannot kill mycoplasma. Broad-spectrum disinfectants, etc., to achieve the effect of improving sterilization efficiency, high disinfection efficiency, and expanding sterilization spectrum

Inactive Publication Date: 2009-11-18
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biggest defect of quaternary ammonium cationic surfactants is their narrow antibacterial spectrum (effective against viruses, bacteria, and fungi, but ineffective against mycoplasma and spores), which greatly limits their clinical use in veterinary medicine.
Although the combined use of single and double-chain quaternary ammonium salts can also improve the disinfection effect, as in U.S. Patent No. 4,464,398, single-chain quaternary ammonium salts are used in conjunction with single-chain quaternary ammonium s

Method used

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  • Disinfectant for animals and preparation method thereof
  • Disinfectant for animals and preparation method thereof
  • Disinfectant for animals and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1, the preparation of veterinary disinfectant

[0038] The formula of veterinary disinfectant of the present invention is as follows (1L):

[0039] component

Content

Glutaraldehyde

2%, that is 20mL

Benzalkonium chloride

1.6%, or 16g

Decyl ammonium bromide

2.4%, or 24g

BRIJ35

0.25%, ie 2.5mL

Isopropanol

15%, that is 150mL

EDTA-2Na

0.1%, or 1g

ascorbic acid

0.1%, or 1g

Phosphate buffer

Add to 1L.

[0040] The preparation method of veterinary disinfectant provided by the present invention comprises the following steps:

[0041] 1) Add glutaraldehyde, isopropanol and polyoxyethylene lauryl ether (BRIJ35) into the container and stir evenly, so that the glutaraldehyde, isopropanol and polyoxyethylene lauryl ether are mixed evenly and completely dissolved, and let stand;

[0042] 2) adding benzalkonium chloride and didecyl dimethyl ammonium bromide (decyl ammo...

Embodiment 2

[0045] Embodiment 2, the preparation of veterinary disinfectant

[0046] The formula of veterinary disinfectant of the present invention is as follows (1L):

[0047] component

Content

Glutaraldehyde

2%, that is 20mL

Benzalkonium chloride

0.2%, or 2g

Decyl ammonium bromide

0.3%, or 3g

BRIJ35

0.25%, ie 2.5mL

Isopropanol

15%, that is 150mL

ethylene glycol

2%, that is 20mL

EDTA-2Na

0.1%, or 1g

ascorbic acid

0.1%, or 1g

Phosphate buffer

Add to 1L.

[0048] The preparation method of veterinary disinfectant provided by the present invention may comprise the following steps:

[0049] 1) Add glutaraldehyde, isopropanol, ethylene glycol and polyoxyethylene lauryl ether (BRIJ35) into the container and stir evenly, so that the glutaraldehyde, isopropanol, ethylene glycol and polyoxyethylene lauryl ether are mixed evenly and completely dissolved, stand still;

[0050] 2...

Embodiment 3

[0053] Embodiment 3, the preparation of veterinary disinfectant

[0054] The formula of veterinary disinfectant of the present invention is as follows (1L):

[0055] component

Content

Glutaraldehyde

1%, that is 10mL

Benzalkonium chloride

2.8%, or 28g

Decyl ammonium bromide

1.4%, or 14g

BRIJ35

0.25%, ie 2.5mL

Isopropanol

10%, that is 100mL

1,2-propanetriol

1%, that is 10mL

EDTA-2Na

0.1%, or 1g

[0056] ascorbic acid

0.1%, or 1g

Phosphate buffer

Add to 1L.

[0057] The preparation method of veterinary disinfectant provided by the present invention may comprise the following steps:

[0058] 1) Add glutaraldehyde, isopropanol, 1,2-glycerol and polyoxyethylene lauryl ether (BRIJ35) into the container and stir evenly, so that glutaraldehyde, isopropanol, 1,2-glycerol and polyoxyethylene The lauryl ether is mixed evenly and completely dissolved, and left ...

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PUM

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Abstract

The invention discloses a disinfectant for animals and a preparation method thereof, belonging to the field of medicines for veterinary use. The disinfectant for animals takes glutaric dialdehyde, single-chain quaternary ammonium salt and double-chain quaternary ammonium salt as active ingredients. The preparation method comprises the following steps: 1) adding glutaric dialdehyde, alcohol and surfactant to a container to stir uniformly and place statically; 2) adding single-chain quaternary ammonium salt and double-chain quaternary ammonium salt; 3) using a part phosphoric acid buffer solution to dissolve the chelating agent and oxidant completely and mixing with the above ingredient; and 4) continuously adding phosphoric acid buffer solution to the formulation amount to obtain a disinfectant stock solution with pH value of 2.5-4.0. The invention has low toxicity, low irritation, small smell, small corrosiveness, high efficiency of disinfection and side disinfecting spectrum. The liquid disinfectant with wide bactericidal spectrum and some washing efficiency is specifically suitable for daily disinfection of colony house, and is suitable for largely popularizing and using.

Description

technical field [0001] The invention relates to a disinfectant, in particular to a compound veterinary disinfectant containing glutaraldehyde and single- and double-chain quaternary ammonium salts suitable for disinfection of livestock and poultry, livestock houses and livestock and a preparation method thereof. Background technique [0002] With the rapid development of intensive breeding industry, it has become an important measure to prevent and control the epidemic of livestock and poultry infectious diseases by using disinfectants to disinfect livestock and poultry and their surroundings to kill pathogens and cut off the transmission route. However, the commonly used disinfectants such as bleaching powder, sodium hypochlorite, peroxide, phenols, formaldehyde, etc. have some common shortcomings, such as poor stability, strong corrosion, strong irritation, etc., and some are also harmful to the human body. It even has carcinogenic effects. [0003] Glutaraldehyde is a br...

Claims

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Application Information

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IPC IPC(8): A61K31/14A61K31/11A61P31/00
Inventor 肖希龙沈建忠汤树生江海洋原霖夏娌君
Owner CHINA AGRI UNIV
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