Therapeutic agent for ameliorating prognosis after lower limb amputation surgery

A therapeutic agent and surgery technology, applied in the field of prognostic therapeutic agents, can solve the problem of not knowing AS-013 and so on
CN101622003AActive Publication Date: 2010-01-06BEIJING TIDE PHARMA

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING TIDE PHARMA
Publication Date
2010-01-06

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Abstract

Disclosed is a therapeutic agent for ameliorating the prognosis after lower limb amputation surgery which is induced by severe peripheral arterial disease. The therapeutic agent comprises a prostaglandin E1 (PGE1) derivative shown by the formula (I) (AS-013) as an active ingredient. Preferably, the therapeutic agent takes a dosage form of a preparation for intravenous or local administration. More preferably, the preparation for injection takes a dosage form of a liposome preparation having the active ingredient AS-013 embedded in a lipid particle.
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Description

【Technical field】

[0001] The present invention relates to the therapeutic agent that improves the prognosis of lower limb amputation operation, specifically, the present invention relates to containing prostaglandin E1 derivative AS-013 as active ingredient, improves the disease caused by severe peripheral arterial occlusion (severe peripheral arterial occlusion (severe peripheral arterial occlusion) A therapeutic agent for the prognosis of lower extremity amputations performed for arterial disease). 【Background technique】

[0002] In recent years, the number of patients with arteriosclerosis obliterans due to arteriosclerosis or diabetes has increased due to Westernization of diet. Obliterative arteriosclerosis will lead to aggravated blood flow disturbances, resulting in severe pain, intractable ulcers, and necrosis (severe lower extremity ischemia), daily life becomes difficult, and quality of life deteriorates. For patients with severe arteriosclerosis obliterans, if ap...

Claims

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