Unlock instant, AI-driven research and patent intelligence for your innovation.

Transglutaminase inhibitor comprising egcg and a method for producing thereof

A technology of transglutaminase and inhibitor, applied in its new application field, can solve the problem of not mentioning transglutaminase inhibitory activity and the like

Inactive Publication Date: 2010-03-31
NAT CANCER CENT
View PDF5 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no mention in the prior art that EGCG has inhibitory activity on transglutaminase, thereby being used as its inhibitor for the treatment of diseases caused by activation of transglutaminase

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Transglutaminase inhibitor comprising egcg and a method for producing thereof
  • Transglutaminase inhibitor comprising egcg and a method for producing thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] [067] Example 1: In vitro analysis of inhibition of transglutaminase activity

[0066] [068] In order to measure the inhibitory activity of EGCG competing with putrescine, it was observed that [1,4,- 14 C] Transglutaminase-catalyzed reaction between putrescine and succinyl casein.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a transglutaminase inhibitor comprising epigallocatechin gallate (hereinafter, referred to as EGCG). More particularly, the present invention relates to a transglutaminase inhibitor comprising EGCG which effectively inhibits the activity of transg not lutaminase, the overexpression of which is responsible for the etiology of various diseases, and to novel uses thereof. According to the present invention, provided is a transglutaminase inhibitor and a method of inhibiting transglutaminase, featuring the use of EGCG as an active ingredient. Featuring the use ofEGCG, the novel method of inhibiting transglutaminase according to the present invention is safely applied to patients who suffer from the diseases caused by the overexpression of transglutaminase, thereby obtaining an inhibitory effect against transglutaminase without causing side-effects.

Description

technical field [0001] [001] The present invention relates to transglutaminase inhibitors comprising epigallocatechin gallate (EGCG). More specifically, the present invention relates to a transglutaminase inhibitor comprising EGCG, which effectively inhibits the activity of transglutaminase, whose overexpression is the cause of the etiology of various diseases, and to novel applications thereof . [002] background technology [0002] [003] Transglutaminase is a protective enzyme that is responsible for blood clotting under normal conditions in response to tissue damage. However, these enzymes have also been reported to play important roles in the pathophysiology of various diseases in which the expression levels of these enzymes lack regulation-control (review paper: Soo-Youl Kim: New Target Against Inflammatory Diseases: Transglutaminase 2.Archivum Immunologiae & Therapiae Experimentalis 52, 332-337, 2004). [0003] [004] After the occurrence of various inflammatory disea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353
CPCA61K31/353A61P1/04A61P1/18A61P5/00A61P11/00A61P13/08A61P13/10A61P13/12A61P15/00A61P17/00A61P25/00A61P25/14A61P25/16A61P25/28A61P35/00A61P35/02A61P43/00
Inventor 金铢烈郑炅采
Owner NAT CANCER CENT