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Application of scullcapflavone in preparing medicament for treating enterovirus infection

A technology of flavonoids of scutellaria baicalensis and enterovirus, which is applied in the field of biomedicine

Active Publication Date: 2010-05-26
BEIJING WEHAND BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the fact that there is no specific therapeutic drug or vaccine for hand, foot, and mouth disease at present, the research content of the present invention has important value and great practical significance for the development of hand, foot, and mouth disease treatment and preventive drugs

Method used

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  • Application of scullcapflavone in preparing medicament for treating enterovirus infection
  • Application of scullcapflavone in preparing medicament for treating enterovirus infection
  • Application of scullcapflavone in preparing medicament for treating enterovirus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The assay of embodiment 1 tested sample

[0040] Test sample: baicalein

[0041] Baicalin

[0042] Scutellaria baicalensis total flavonoids extract 1

[0043] Scutellaria baicalensis total flavonoids extract 2

[0044] Determination method: take appropriate amount of four groups of test samples, weigh them accurately, add methanol to dissolve and dilute to a solution with a concentration of 1.0 μg / mL, filter, take the subsequent filtrate as the test solution; take baicalein, baicalin An appropriate amount of glycoside reference substance was prepared in the same way as a corresponding reference substance solution; the contrast solution and the test solution were measured respectively, and determined according to the HPLC method. The elution gradient is shown in the table below, the flow rate is 1mL / min, the injection volume is 20μL, the detection wavelength is 275nm, and the detection is at room temperature.

[0045] The contents of baicalein and baicalin were calcu...

Embodiment 2

[0049] Example 2 The inhibitory effect of baicalein on enterovirus

[0050] According to the in vitro antiviral test method under the content of the invention, investigate the baicalein test sample according to law to Coxsackie virus A16 type (Cox A16), enterovirus 71 type (EV 71), Coxsackie virus A5 type (Cox A5) and Coxsackie virus type B2 (Cox B2) caused cytopathic inhibition, the results of the investigation are shown in the following table:

[0051] Table 2: Inhibitory effects of baicalein on different enteroviruses

[0052]

Embodiment 3

[0053] Embodiment 3: the inhibitory effect of baicalin on enterovirus

[0054] According to the in vitro antiviral test method, the test samples of baicalin were investigated according to the law against Coxsackie virus A16 (Cox A16), enterovirus 71 (EV 71), Coxsackie virus A5 (Cox A5) and Coxsackie virus. Inhibition of cytopathic effect caused by strange virus B2 type (Cox B2), the investigation results are shown in the following table:

[0055] Table 3: Inhibitory effects of baicalin on different enteroviruses

[0056]

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Abstract

The invention discloses new application of scullcapflavone in preparing a medicament for treating enterovirus infection, in particular new application of scullcapflavone in preparing a medicament for treating or preventing a hand-foot-and-mouth disease caused by enterovirus infection. The scullcapflavone comprises an extract of baicalein, baicalin or scutellaria baicalensis general flavone; and the enterovirus indicates a coxsackie virus A group, a coxsackie virus B group, echovirus or enterovirus EV71 which causes the hand-foot-and-mouth disease. The scullcapflavone as an active substance is mixed with a pharmaceutically allowable excipient and made into a preparation which can be accepted by a patient and can be used for treating and preventing the hand-foot-and-mouth disease by injection administration, mucosa administration, oral administration or inhalation and has obvious treating effect and high safety.

Description

[0001] The invention relates to the new use of baicalin flavones in the preparation of drugs for treating enterovirus infection. Specifically, the new use of baicalin flavones in the preparation of drugs for treating or preventing hand, foot and mouth disease caused by enterovirus infection belongs to the technical field of biomedicine. Scutellaria baicalensis specifically includes baicalein, baicalin and total flavonoids extract of Scutellaria baicalensis. Enterovirus refers to Coxsackievirus A, Coxsackievirus B, echovirus and enterovirus EV71 that cause hand, foot and mouth disease. The baicalin flavonoids are mixed as an active substance with pharmaceutically acceptable excipients to prepare a preparation that can be accepted by patients, and can be used for the treatment and prevention of hand, foot and mouth disease through injection, mucosal, oral or inhalation administration. Background technique [0002] Hand-foot-mouth disease (HFMD) is a common infectious disease cau...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K31/352A61K31/7048A61K9/127A61K47/28A61K47/36A61P31/12
Inventor 刘家琛曲敬来刘玉玲温纯青温育青曾晓莲高雪
Owner BEIJING WEHAND BIO PHARMA CO LTD
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